Bradybomb
New Member
Hey everyone,
I’ve been diving into the theoretical aspects of alternative administration routes for steroids and wanted to discuss rectal administration, using Primobolan Acetate as an example.
Primobolan Acetate reportedly has ~2-5% oral bioavailability (correct me if I’m wrong), primarily because it undergoes significant destruction during the first pass through the liver. Injectable versions have been created, and while they can deliver great results, they’re notorious for causing severe injection site reactions, including welts and flu-like symptoms, making them impractical for many users.
This got me thinking: what about rectal administration as an alternative? It could bypass much of the liver’s first-pass metabolism while potentially providing a steady absorption profile.
Here’s the theoretical plan:
• Using pure raw powder of Primobolan Acetate.
• Dissolving it in a mixture of ethanol and PEG-400 to create a solution with a concentration of 100-150mg/ml (as high as practical for absorption without irritation).
• Administering the solution rectally with the aim of maximizing absorption and minimizing liver metabolism.
The goal would be to achieve higher bioavailability than oral administration without the injection site issues. Obviously, there would still be challenges like potential irritation from the solvent system and the unknowns of absorption efficiency via this route.
Has anyone explored this method for any compounds, or are there studies that touch on rectal absorption of steroids or similar lipophilic drugs?
I’ve been diving into the theoretical aspects of alternative administration routes for steroids and wanted to discuss rectal administration, using Primobolan Acetate as an example.
Primobolan Acetate reportedly has ~2-5% oral bioavailability (correct me if I’m wrong), primarily because it undergoes significant destruction during the first pass through the liver. Injectable versions have been created, and while they can deliver great results, they’re notorious for causing severe injection site reactions, including welts and flu-like symptoms, making them impractical for many users.
This got me thinking: what about rectal administration as an alternative? It could bypass much of the liver’s first-pass metabolism while potentially providing a steady absorption profile.
Here’s the theoretical plan:
• Using pure raw powder of Primobolan Acetate.
• Dissolving it in a mixture of ethanol and PEG-400 to create a solution with a concentration of 100-150mg/ml (as high as practical for absorption without irritation).
• Administering the solution rectally with the aim of maximizing absorption and minimizing liver metabolism.
The goal would be to achieve higher bioavailability than oral administration without the injection site issues. Obviously, there would still be challenges like potential irritation from the solvent system and the unknowns of absorption efficiency via this route.
Has anyone explored this method for any compounds, or are there studies that touch on rectal absorption of steroids or similar lipophilic drugs?
