MESO-Rx

Anabolic Steroids

Steroidsfax Test e/Deca/Dbol/Proviron

Iatola said:
I believe it binds to the aromatase enzyme not the receptor itself. And it's the enzyme that is responsible for converting test to e.

Therefore it should help prevent at least some of the sides associated with estrogen build up while on cycle.

Anyway, that was my train of thought, that's why I'm using it as an anti-e while on cycle.
Click to expand...

Yes sir, I agree it does have the effect of helping with neg e sides.

Dr JIM said:
The primary effect of Proviron is it's binding to SHBG with five time the affinity than DHT and much more so then with either E-2 or Testosterone.

The NET EFFECT is more androgen circulating as UNBOUND and becoming "free" to participate in metabolic functions, at least initially. Proviron has no effect on the aromatase activity and does NOT decrease the conversion of Test into E-2.

Much of the confusion of DHT AAS analogs, LIKE Proviron, arose out of the supposition that because Masteron was used in 1970s for breast cancer patients (with a demonstrable reduction in mortality) it was thought by some the "binding E-2 receptors" was it's MECHANISM OF ACTION.

The result was yep...... BRO SCIENCE STRIKES AGAIN! Well truth be known, the technology required to DETERMINE the RECEPTOR STATUS was not available until the 1990's, but as one can imagine the NAME "anti-estrogenic stuck".

In fact it is now known up to 40% of patients with breast cancer are ESTROGEN RECEPTOR NEGATIVE yet ANDROGEN RECEPTOR POSITIVE !!!!!.

Now it just so happens Masteron is an ANDROGEN and it's ability to activate the androgen receptor in females with breast cancer was the underlying MECHANISM OF ACTION.
Stated another way Masteron or presumably any other AAS, including Proviron, may be effective in breast cancer because they are androgenic rather than being anti-estrogenic, WHICH THEY ARE NOT!

JIM
Click to expand...

Yeah, what he said.^^^^Thanks Doc.
 
Well thanks for the info guys, obviously there are conflicting ideas on exactly what proviron does depending on the source.

But reguardless, I'm less concerned with how it does what it does, as long as it does what I need it to do :)
 
Iatola said:
Well thanks for the info guys, obviously there are conflicting ideas on exactly what proviron does depending on the source.

But reguardless, I'm less concerned with how it does what it does, as long as it does what I need it to do :)
Click to expand...

I hear you my man. I haven't used prov since the 90's when I'd get it from Mx. All I knew then was that it was supposed to suppress neg e sides. I thought it was just weak and didn't do much.
I've got friends that run it every cycle and give large praise. I'm told sexual function gets cranked up too. I plan on implementing very soon. I believe I underestimated this drug.
 
raysugar1234 said:
So exactly what is the point of proviron?
Click to expand...

Here's a good read:

Proviron has four distinct uses in the world of bodybuilding. The first being the result of its structure. It is 5-alpha reduced and not capable of forming estrogen, yet it nonetheless has a much higher affinity for the aromatase enzyme (which converts testosterone to estrogen) than testosterone does. That means in administering it with testosterone or another aromatizable compound, it prevents estrogen build-up because it binds to the aromatase enzyme very strongly, thereby preventing these steroids from interacting with it and forming estrogen. So Mesterolone use has the extreme benefit of reducing estrogenic side-effects and water retention noted with other steroids, and as such still help to provide mostly lean gains. Its also been suggested that it may actually downgrade the actual estrogen receptor making it doubly effective at reducing circulating estrogen levels.

The second use is in enhancing the potency of testosterone. Testosterone in the body at normal physiological levels is mostly inactive. As much as 97 or 98 percent of testosterone in that amount is bound to sex hormone binding globulin (SHBG) and albumin, two proteins. In such a form testosterone is mostly inactive. But as with the aromatase enzyme, DHT has a higher affinity for these proteins than testosterone does, so when administered simultaneously the mesterolone will attach to the SHBG and albumin, leaving larger amounts of free testosterone to mediate anabolic activities such as protein synthesis. Another way in which it helps to increase gains. Its also another part of the equation that makes it ineffective on its own, as binding to these proteins too, would render it a non-issue at the androgen receptor.

Thirdly, mesterolone is added in pre-contest phases to increase a distinct hardness and muscle density. Probably due to its reduction in circulating estrogen, perhaps due to the downregulating of the estrogen receptor in muscle tissue, it decreases the total water build-up of the body giving its user a much leaner look, and a visual effect of possessing "harder" muscles with more cuts and striations. Proviron is often used as a last-minute secret by a lot of bodybuilders to deliver top shape when needed. Like the other methylated DHT compound, drostanolone, mesterolone is particularly potent in achieving this feat.

Lastly Proviron is used during a cycle of certain hormones such as nandrolone, with a distinct lack of androgenic nature, or perhaps 5-alpha reduced hormones that don't have the same affinities as DHT does. Such compounds, thinking of trenbolone, nandrolone and such in particular, have been known to decrease libido. Limiting the athlete to perform sexually being the logical result. DHT plays a key role in this process and is therefore administered in conjunction with such steroids to ease or relieve this annoying side-effect. Proviron is also commonly prescribed by doctors to people with low levels of testosterone, or patients with chronic impotence. Its not perceived as a powerful anabolic, but it gets the job done equally well if not better than other anabolic steroids making it a favorite in medical practices due to its lower chance of abuse.
Click to expand...

One of the members at steroidology did a pretty good write-up if you want to read the rest of it:

http://www.steroidology.com/forum/anabolic-steroids-bodybuilding-articles/10-proviron-all-you-need-know-part-1-a.html

but there is tonnes of info on proviron the web.
 
Iatola said:
Here's a good read:



One of the members at steroidology did a pretty good write-up if you want to read the rest of it:

http://www.steroidology.com/forum/anabolic-steroids-bodybuilding-articles/10-proviron-all-you-need-know-part-1-a.html

but there is tonnes of info on proviron the web.
Click to expand...

very good read, you got my attention. Think i'll be adding this to my cycle it's certainty cheap enough and those benefits are definitely worth it.
 
NO it's a read that's full of unsupported bro science, BULLSHIT!
Proviron DOES NOT BIND AROMATSE, thereby "consuming it's availability for other circulating anabolics". The notion is utterly absurd, period!

None of the DHT or "progesterogenic" analog AAS (Anavar, Turnibol, Masteron, Proviron and Bolo, Tren, Deca respectively) bind aromatase if they did or could they would be converted into E-2. The chemical structure of aromatase will not allow this to occur. It's like inserting a square key in a round key hole.

I will tell you fellas believe what you want but Steroidology.com is one of the WORST supporters of propagating "bro dogma". They also state, in several different locations, "rebound" (an INCREASE of E-2 ABOVE baseline) occurs upon the from the discontinuation of SERMS, in spite of clear and convincing evidence to the contrary.

Scan thru their site, can you locate any reference which support their commentary? Very little if any, and in this instance NONE!

JIM
 
Jim, that article on steroidology was one of many articles I've read on Proviron, and most say more or less the same thing. Does this lend credibility to any of these articles or what they propose, absolutely not; but, right now that's all i have to go on.

So if you have any articles or better yet actual research work based on "real science", I'd love to see it.
 
That's not an article it's someone's baseless, uneducated and regurgitated opinion. There are enumerable citations based on medical "research", on Medline where the information I parlay is readily accessible and that's in addition to the majority of AAS information located on the Meso website which IS REFERENCED!

I promise you will actually learn something should you chose a reliable source and STEROIDOLOGY IS NOT IT!
 
I usually decide what I am going to
do 1st, then I find an article, to back it up.

Even if it's on Joeschmobodybuilding.com
I will search until my fingers bleed

My goal in life is not to find
out the truth, it's to make shit
up as I'm going along ... I like it.. It works for me :)

I am always trying to re-invent the wheel
 
Yea but your a "pro" whom has made "all the mistakes known to mankind" (AKA Man Whore) such that a "pass" seems absolute, lol!
 
Oh and of course, excluding the millions I'm reimbursed by Millard to support Meso (and criticize every other AAS site) my opinions are indeed unbiased, lol!
:)
 
I just wanna get back, on cycle.

I wish I could have posted
or taken a pic of my abs,
before I got locked up.

This time I am going all out
and posting some nice pics.

I won't even be embarrassed,
to post before pics.
 
Dr JIM said:
That's not an article it's someone's baseless, uneducated and regurgitated opinion. There are enumerable citations based on medical "research", on Medline where the information I parlay is readily accessible
Click to expand...

That's good, it's just when you reference something and you don't back it up with a source how does anyone else know it's not just more "bro-science" just because you say it's not. As I said before I'm not very active on this board, so I don't know you from anyone else on here.

Anyway, thanks for the source. now I'll go see what I can find on Proviron.
 
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