To begin with:
I do not recall declaring a shelf-life for my products.
I have told many people that I personally use some things from over a year ago; but I have never “declared” anything of the sort. These drugs are illegal and prepared by a guy that makes a living in a different field. I haven't and won't declare any sort of shelf life on anything.
I think some common knowledge would apply to most things, such as: If you leave it in the truck in July; it's probably not good anymore---- If it is growing mold; don't drink it.---- If you bought it a year ago and feel sketchy about using it; don't use it. I don't know if a lot of guys that buy these things do so to stockpile for Armageddon; but if that is the case----- I have no recommendations.
Please forward me the information of these PED medications that are reduced to 60% efficacy by suspension. I have not found this in hours of exhaustive searching; and the information would be vital to my work on this.
The suspending vehicle I use is a commercially prepared formulation from a regional pharmacy supply company. I would assume it is very similar to the Humco and Ora brands. I know that the suspending agents in the vehicle are: microcystalline cellulose, carboxymethylcellulose, xanthan gum, and caragenan. It is slightly acidic with pH of 5 and is stable at ambient temperature of ~70 degrees F.
There is limited information available about suspension for many APIs. It has been documented that the following APIs were tested in suspension at 90 days; and at least 90% of the API was detected by HPLC:
oxandrolone
tamoxifen
sildenafil
tadalafil
letrozole
anastrozole
raloxifene
stanozolol (aqueous suspension).
All of these, with the exception of stanozolol, were extemporaneously compounded in a vehicle nearly identical to the one I use.
It is my assumption that other steroid hormones would behave similarly to oxandrolone since they share some common solvents and chemical/physical properties; but there is no high quality data regarding this assumption. I suspect that is because the use of oxymetholone and metandienone is relatively rare in human medicine any more; and some of the chemicals we use were never intended for humans to begin with.
With that said; I have had no doubts about their efficacy in the time period that I have used them.
The common precaution I have found regarding hormone degradation is regarding light: not pH or temperature.
As with everything else, recommendations change frequently. There is a guide on the USP website with new blanket recommendations from 2019. These recommendations do not align with what I have experienced in my personal use; nor do they align with the literature from the tests that have been performed on the above listed compounds.
If interested, there is some information that can be found by using the DOI or webpage links below.
DOI 10.2146/ajhp100225
DOI 10.2146/ajhp110034
https: //www.sefh.es/fichadjuntos/EXTPREP_citos.pdf
https: //www.usp.org/sites/default/files/usp/document/our-work/compounding/usp-bud-factsheet.pdf
The short version of my stance on it is: 1) there is no literature supporting degradation in suspension of the APIs that I offer in suspension; and 2) I do not intend to make batches large enough that I would question their efficacy for months after I sell them.
I, personally, would not use a 3 year old suspension or tablet/capsule.
In the end, I make absolutely no declarations of the long-term storage and efficacy of anything I offer. I do still use things I made in 2017 with good results; but that is a personal experience story; not an advisement or declaration of shelf life.
