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Anabolic Steroids

Thyroid Replacement Therapy?

another question, to get to my final dosage do i start like this
day 1: 12.5mg
day 2: 25mcg
day 3: 37.5mcg
day 4: 50mcg
and so on? or i increase dosage every week?
 
ItsOnlyCreatineBro said:
another question, to get to my final dosage do i start like this
day 1: 12.5mg
day 2: 25mcg
day 3: 37.5mcg
day 4: 50mcg
and so on? or i increase dosage every week?
Click to expand...
Oral levothyroxine has an apparent elimination half life of 7 days. So you'd start with 25 (very conservative) or 50 (less conservative) mcg and take that daily for 12 weeks. The first 30 days your body is ramping up to steady state blood levels.

In 12 weeks you'd pull labs and assess along with symptoms.


There is also an approach to attain stable blood levels faster but not needed here IMO.

I'd recommend you starting doing a lot of reading so many of these concepts around pharmacokinetics, pharmacodynamics start to gel.

Best wishes.
 
www.ncbi.nlm.nih.gov

The Relationship between Population T4/TSH Set Point Data and T4/TSH Physiology

Context. Population studies of the distribution of T4/TSH set points suggest a more complex inverse relationship between T4 and TSH than that suggested by physiological studies. The reasons for the similarities and differences between the curves describing ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

www.ncbi.nlm.nih.gov

TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis

This paper provides the reader with an overview of our current knowledge of hypothalamic-pituitary-thyroid feedback from a cybernetic standpoint. Over the past decades we have gained a plethora of information from biochemical, clinical, and epidemiological ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
 
www.frontiersin.org

Frontiers | Homeostatic Control of the Thyroid–Pituitary Axis: Perspectives for Diagnosis and Treatment

The long-held concept of a proportional negative feedback control between the thyroid and pituitary glands requires reconsideration in the light of more rece...
www.frontiersin.org www.frontiersin.org

www.ncbi.nlm.nih.gov

Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research

Although technical problems of thyroid testing have largely been resolved by modern assay technology, biological variation remains a challenge. This applies to subclinical thyroid disease, non-thyroidal illness syndrome, and those 10% of hypothyroid patients, ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

It is a humbling field. Start slow and find a good Endo you trust.
 
ItsOnlyCreatineBro said:
I already talked to at least 12 endocrinologists and they all keep saying same thing or that its all in my head....
Click to expand...
Ok, well I shared a hypothetical conservative approach that won't mess you up if you decide to test your hypothesis....exogenous levothyroxine will improve my symptoms. Target TSH is hard to nail down. 1 to 3 is plausible. You always here these internet nuts state that 1 or less than 1 is optimal whatever the hell that is. Also your TSH can fluctuate for all kinds of reasons even with exogenous T4. That's why serum fT4 and fT3 labs are helpful but even they don't tell the whole picture. We don't yet treat the thyroid based on tissue biopsy results yet.
 
Last edited:
I got some 12.5mcg t4 bottle now so i will try taking it from tomorrow. I read that T4 needs to be taken fasted but I also read T4 can be take before sleep assuming nothing eaten 2 hours before. So I'm not sure which one I should follow.
 
ItsOnlyCreatineBro said:
I got some 12.5mcg t4 bottle now so i will try taking it from tomorrow. I read that T4 needs to be taken fasted but I also read T4 can be take before sleep assuming nothing eaten 2 hours before. So I'm not sure which one I should follow.
Click to expand...
Morning, wait at least an hour before eating. I get up a few hours take with water and back to sleep.
 
buck said:
Higher levels seem better to long life from most of my reading. Low serum T4 and a high serum TSH concentration where the range to shoot for. it seems for long term.
Extreme Longevity Is Associated with Increased Serum Thyrotropin
Click to expand...
As long as you go in understanding that AA stands for accelerated aging instead of anti aging then you are ahead of the curve. Pay to play in more ways than one.

Great to bring up the performance longevity tradeoff. Weight training on its own seems like a no Brainer for everyone but screwing with hormones may have a significant penalty function. Thanks.
 
readalot said:
As long as you go in understanding that AA stands for accelerated aging instead of anti aging then you are ahead of the curve. Pay to play in more ways than one.

Great to bring up the performance longevity tradeoff. Weight training on its own seems like a no Brainer for everyone but screwing with hormones may have a significant penalty function. Thanks.
Click to expand...
It seems from my reading that moderate weight training as in other training may be advantageous. But past that seems to have no benefit that i can see. and can be less healthy from my reading. If longevity is the goal. I lift as i like to and for quality of life and have decided the down side of what i do is worth the negative risks. . When i read of people in their 90's or 100's i do not see where in general they were physically extreme at anything. Mostly moderate and kept their weight down all their lives. Ate fairly healthy and were moderate at most in most everything.
 
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