Why do some people suggest am AI during a cycle?

[ChestRockwell]

Not entirely correct about the nandrolone part.

AI's do work on nandrolone but not entirely bc some of the nandrolone is aromatized in the testes. AI's cannot cross the blood testes barrier and therefore don't work on the testicular aromatization much like that of HCG. To say thy do absolutely nothing for nandrolone though isn't accurate.

From what I understand, based on the following literature, nandrolone's conversion is related to estren (19-Nor-4-androstene-3α,17β-diol) and if you look at the second study the researchers actually show that there was zero impact on nandrolone's conversion to estrogen using an aromatase blocker (aminoglutethimide).

And this also is in line with my anecdotal experience over the years with many of my athletes. About the only thing that "works" is using nolvadex as a "band-aid" until nandrolone can be lowered below the problematic threshold and/or removed altogether.

J. Shields-Botella, I Duc, E. Duranti, F. Puccio, P. Bonnet, R. Delansorne, J. Paris. An overview of nomegestrol acetate selective receptor binding and lack of estrogenic action on hormone-dependent cancer cells. Journal of Steroid Biochemistry & Molecular Biology 87 (2003) 111-122.

J. Botella,t E. Duranti, V. Viader, I. Duc, R. Delansorne, J. Paris. Lack of Estrogenic Potential of Progesterone- or 19-Nor-progesterone-derived Progestins as Opposed to Testosterone or 19-Nor- testosterone Derivatives on Endometrial Ishikawa Cells. Steroid Biochem. Molec. Biol. Vol. 55, No. 1, pp. 77-84, 1995.

 

[Docd187123]

From what I understand, based on the following literature, nandrolone's conversion is related to estren (19-Nor-4-androstene-3α,17β-diol) and if you look at the second study the researchers actually show that there was zero impact on nandrolone's conversion to estrogen using an aromatase blocker (aminoglutethimide).

And this also is in line with my anecdotal experience over the years with many of my athletes. About the only thing that "works" is using nolvadex as a "band-aid" until nandrolone can be lowered below the problematic threshold and/or removed altogether.

J. Shields-Botella, I Duc, E. Duranti, F. Puccio, P. Bonnet, R. Delansorne, J. Paris. An overview of nomegestrol acetate selective receptor binding and lack of estrogenic action on hormone-dependent cancer cells. Journal of Steroid Biochemistry & Molecular Biology 87 (2003) 111-122.

J. Botella,t E. Duranti, V. Viader, I. Duc, R. Delansorne, J. Paris. Lack of Estrogenic Potential of Progesterone- or 19-Nor-progesterone-derived Progestins as Opposed to Testosterone or 19-Nor- testosterone Derivatives on Endometrial Ishikawa Cells. Steroid Biochem. Molec. Biol. Vol. 55, No. 1, pp. 77-84, 1995.

I gotta check my references but I think dr Scally and/or dr. Jim touched on this once. Maybe I'm wrong lol

 

[ChestRockwell]

I gotta check my references but I think dr Scally and/or dr. Jim touched on this once. Maybe I'm wrong lol

No worries, if you do happen to have anything further, please send it my way!

 

[Docd187123]

No worries, if you do happen to have anything further, please send it my way!

Of course. I have a bunch of stuff saved on my phone but the charging port crapped out. I'm using my old phone now and it doesn't have shit on it. Once I get it repaired I should be able to forward you anything I have.

 

[Serpes]

Should I use Nolva instead of an AI during my first cycle?

 

[mands]

Should I use Nolva instead of an AI during my first cycle?

Do you have pre-cycle labs? Have you had a history of pubescent gyno or any other e2 issues?

I would say no. I would actually get labs again about 4-5 weeks into the cycle and see how you are feeling and what your e2 levels are. This would determine for me how much and what to run as far as an AI.

Others might feel differently.

mands

 

[The Rock]

Cycle without an AI and let us know what happens. I have a discount code for lace bra's on ebay if you need it. No but serious have an AI on hand and bloods are always your best bet

Lol exactly.

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[The Rock]

If you are needing AIs then you likely are either running too much gear, or have a very poorly designed blast.

Docs give it during trt at 200g Cyp a week.

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[ChestRockwell]

Lol exactly.

It is really quite unfortunate that folks still spread this type of sentiment, particularly on boards where the majority of individuals may not have much AAS experience.

 

[The Rock]

I'm pretty sure the group on meso are well informed. Use aromasin when using test or you will be crying like a girl curling up on your couch watching love stories with sore nips

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[w1ck3d]

So you're saying use an ai right off the rip otherwise anyone on test is a emotional pussy?

 

[Docd187123]

I'm pretty sure the group on meso are well informed. Use aromasin when using test or you will be crying like a girl curling up on your couch watching love stories with sore nips

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This made me laugh but unfortunately it's due to the misinformation contained and not bc it was comedic in nature.

 

[w1ck3d]

This thread has me all sorts of mind blown about ai's

 

[Jeremiahflex]

It is really quite unfortunate that folks still spread this type of sentiment, particularly on boards where the majority of individuals may not have much AAS experience.

I thought this thread died lol. After more people chimed in I agree it's probably not always needed, I keep it as added security though.

 

[Ryno1980]

Ok so I'm revisiting this thread because I'm 2 weeks in on my cycle and trying to use some advice I was skeptical about ... so here it is, first I'm gyno prone, a have a tiny lump above right nipples that seems to be easily aggrivated...
Cycle is 16 weeks of deca at 600 a week, 900 test e a week.... weeks 1-6 I added npp at 400 a week...
I've been using my ai lightly, 1mg adex on pin days... other than that I'm taking 20mg nolvadex ed from the start..... what I've noticed so far, is that my tiny lump seems to stay tender but hasn't grown in size .... I would have thought based on info from several of you, sensative type would not have been an issue as the nolva should block the effects of the nandro? am I looking at this wrong? and what changes should I look at if any @Docd187123

 

[Docd187123]

Ok so I'm revisiting this thread because I'm 2 weeks in on my cycle and trying to use some advice I was skeptical about ... so here it is, first I'm gyno prone, a have a tiny lump above right nipples that seems to be easily aggrivated...
Cycle is 16 weeks of deca at 600 a week, 900 test e a week.... weeks 1-6 I added npp at 400 a week...
I've been using my ai lightly, 1mg adex on pin days... other than that I'm taking 20mg nolvadex ed from the start..... what I've noticed so far, is that my tiny lump seems to stay tender but hasn't grown in size .... I would have thought based on info from several of you, sensative type would not have been an issue as the nolva should block the effects of the nandro? am I looking at this wrong? and what changes should I look at if any @Docd187123

Sensitivity can be from anything really. If it hasn't grown when it normally would have, then you know the nolva is working for you.

 

[Les]

Good thread with good info. Thanks

 

[The Rock]

Cycle without an AI and let us know what happens. I have a discount code for lace bra's on ebay if you need it. No but serious have an AI on hand and bloods are always your best bet

Lol
Yep all true he will find out the hard way


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[ChestRockwell]

Lol
Yep all true he will find out the hard way

No. You can always tell the folks with a lack of hormonal knowledge as there is often a direct correlation to the amount of parroting and fear mongering they participate in.

 

[Les]

I started with a trt clinic long before this adventure and they always had me on adex so it's good to read educated different opinions on this subject.
Now I need to do more reading on it.

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