2,4-DiNitroPhenol [DNP]

Heretic

New Member
Credit to the gods that wrote this... :)

HOW TO NOT FUCK UP DNP:

Since some guys have been playing around and disrespecting DNP and then griping to the forums about the painful results, we need to make this VERY specific and VERY correct so that people won't keep jumping for DNP out of curiosity, or without the willpower they need to operate this respondibly. So here are my experienced guidelines to using it the RIGHT way.

FIRST GUIDLINE: Dosing. Use ONLY 200mg a day for the first four days. I don't care that you don't "feel" anything yet and you wanna bump it up. DNP accumulates in the body, and not "feeling" something means NOTHING. It's there, and it's working (the effect on metabolism begins within two hours of the first dose!). Four days will let you test your tolerance: do you have an allergy? Does it give you a rash? etc.
Only after those four days do you bump it up, by 200mg a day. The average dose is 400-600/day, and more than that gets a little severe. A full gram is the highest dose I've heard anyone use. I've used that much, and it's hell. I like to stay around 600 a day, which is HOT but safe and effective. Take caps even hours apart through the day, ending about 4-5 PM.

SECOND GUIDLINE...How to eat on DNP. This is purely personal experience, because some guys like to carb-deplete *before* using DNP (then eat carbs as usual while on), and other guys like a low-carb approach throughout. Both are fine. Using DNP is the only time that fructose is a desireable cutting carb, because it keeps the liver replentished. That reduces lethargy and spares muscle.
Be aware that eating high-carb foods WILL increase the heat sensation within an hour, and last about 2 hours. That means don't eat carbs before bed unless you want those night sweats to be even WORSE.
Personally, I ate whatever the hell I wanted! IHOP, chinese, fajitas...Yes, I burned hot, but I still lost 1.5 pounds every 2 days. Keep protein HIGH for muscles' sake, and try it yourself.

Foods I suggest including:
Blueberry yogurt. Blueberries are excellent antioxidants, and yogurt cultures help with digestive function, gas, and stool consistency (disgustingly soft stools are common during DNP).
Oregano-based foods. Oregano is perhaps one of the most potent antioxidants around,a nd one spoonful counts as a vegetable serving. See this article
Pineapple - I've found that pineapple helps alleviate those "DNP Blues". The fructose helps, and pineapple enzymes aid in protein digestion.
V8 - one 12-ounce can supplies six servings of veggies, concentrated as an excellent source of antioxidants, lycopene, and recovery of electrolytes.
Oatmeal - high-fiber foods are necessary. You'll find out why around, oh, day 5 or so. Trust me.


THIRD GUIDELINE...Supplements and DNP. I suggest:
ECA - DNP is not a stimulant. To keep energy high and aid in fat loss, use an ECA. Some advisors suggest that regular ephedrine is preferable to norephedrine because of the more direct "hit" of energy.
Prohormones - perfectly fine on DNP. I used 1-AD just to help keep strength and muscle up, and it worked fine. No problems here. You won't GROW muscle on DNP, but it'll help with strength and protection.
Obvious stuff - multivitamin, ZMA, etc.
Biotest PowerDrive - No, I'm not pimping Biotest. But PowerDrive is an excellent pre-workout mixture that actually works. Plus it's low-carb (only 15 calories total), so it won't cause carb-heat in the middle of your workout.

Antioxidants - I'm giving my own personal list, and why I use them:
Alpha Lipoic Acid - aids in fat management and blood sugar, and an excellent antioxidant.
Grape seed extract
Syntrax Radox
Green Tea
Inositol - mood enhancement, antioxidant, and muscle support. 1 gram/3x day
Ellagic acid - protects cell DNA/RNA from damage by free radicals, and may even atack cancerous cells. 400mg/twice a day
Fruit antioxidants - beyond-a-century's powder of high-potency natural fruit anti's. 1 gram, 2-3x day.
Trimethylglyceine - antioxidant, helps move fat and blood lipids into the liver and out of the body. 500mg, 2x day.
Vitamins E and C

Supplements NOT to use:
Any medications that suppress energy. No allergy meds, antidepressants, muscle relaxers, or beta blockers. DNP will have you low as it is; don't worsen your body's energy by taking something that suppresses you further.

DRUGS - Sheesh, you'd think I wouldn't have to mention this, but two idiots in particular (right here on this forum) recently affirmed that some people still just don't get it. NO alcohol (not even "moderate"), NO ecstasy, NO GHB, etc. If you don't have the willpower to forego these habits, DNP is not for you.

Syntrax Swole - a personal discovery. I tried Swole while on DNP...once. Two hours of hell, feeling inside-out.

FOURTH GUIDELINE...working out on DNP. Keep lifting short, 30-40 minutes. DNP works very well, causing your body to use 150% or more the calories per action you'd normally use. That means DON'T try to repeat your usual workouts. Drop to moderate weights, 8-12 reps, not to failure, and with plenty of walking rest between sets. You are NOT going to grow muscle on DNP, so don't use your usual heavy routine. Since DNP can cause light-headedness and heat dizzyness, you have my permission to skip squats in favor of leg presses this time.

Cardio is a controversial one. My advice - do NOT do cardio on high doses of DNP (600mg or more). It's dangerous and counterproductive. Below that amount, some cardio is fine, but keep it to 20 minutes and not at full-gallop. Remember, DNP will drain water from your quickly, causing you to leech out minerals, vitamins, and salts. Don't overdo it.

During exercise, consume at least 1 liter of water per 30 minutes of work, whether you're thirsty or not. DNP is evil in the way it blunts thirst, while at the same time doing the cruel trick of bloating your body with water WHILE dehydrating you from water in your organs. MAKE yourself drink. Always folllow DNP exercise with antioxidants, carbs, and this is a good time to use your multivitamin.

Don't feel embarrassed about poor workouts. Just this morjning I did a workout with a whopping nine sets (wimp!) before calling it quits. Listen to your body, and let it tell you when enough's enough; don't guage workouts by what you *usually* can do otherwise.

Here's my research. This is AMAZING! Not only has not a single test found it to be carcinogenic, but test after tyest after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%. The summaries are all right here, friends. Karma me up!

DNP is Ames negative, and does not promote tumors. See for yourself at http://toxnet.nlm.nih.gov/

http://www.epa.gov/ttn/atw/hlthef/dinitrop.html (2,4-Dinitrophenol | Technology Transfer Network Air Toxics Web site | US EPA) reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.

Cyberiron.com reports on halth risks from external exposue. In other words, don?t get it in your eyes, or on your skin if you?re allergic. Pretty elementary stuff.

http://www.ebec2000.com/abstracts/056.htm This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.

Biosource A PDF file about an antidote to DNP.

http://www.boehringer-ingelheim.es/...glesa/cap13.htm finds that DNP did not activate liver enzymes (MAT) associated with liver damage

"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.

"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know?it?s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst results being softened stools and gas).

"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as?2,4-dinitrophenol (DNP)."

"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out?DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure?"


"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.

Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it?s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer?fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.

"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it?s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity?"

"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP?s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.

"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.

"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates?or disrupts?cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.

"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT (good ol? DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect?"

"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide by neutering themselves. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."

"Autocatabolism of surface macromolecules shed by human melanoma cells." Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps melanoma cells die (autocatabolize) while other cells are unaffected.

http://www.geocities.com/byggdegstor/dnpforside - tons of research, including medical studies. Excerpts:

DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation ? 1996 Robert Ames)

Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."

"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."

"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."

"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."

"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."

"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."


Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
 
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This stuff pisses me off. Your "blitz cycle" is a great way to end up dead or in the hospital. What the hell are you doing? A gram a day for 3 days? That's moronic. A girl in London just died after taking a gram on the last day of her cycle. A few months ago a different girl died after taking a gram a day for a few days. I'm guessing that If your DNP wasn't underdosed, you'd probbaly be dead right now too.

DO NOT do high dose "inferno cycles" or "blitz cycles". You simply cannot take DNP safely with retardley high doses for several days in a row. Don't be stupid. Learn how to use DNP or don't use it all. It's people like you who end up dead after using DNP irresponsibly.

And yes, the 36 hour half-life means that after 36 hours, half of the DNP will still be in your body. Plan to sweat your ass of at your job... if you're not in the hospital.
 
This stuff pisses me off. Your "blitz cycle" is a great way to end up dead or in the hospital. What the hell are you doing? A gram a day for 3 days? That's moronic. A girl in London just died after taking a gram on the last day of her cycle. A few months ago a different girl died after taking a gram a day for a few days. I'm guessing that If your DNP wasn't underdosed, you'd probbaly be dead right now too.

DO NOT do high dose "inferno cycles" or "blitz cycles". You simply cannot take DNP safely with retardley high doses for several days in a row. Don't be stupid. Learn how to use DNP or don't use it all. It's people like you who end up dead after using DNP irresponsibly.

And yes, the 36 hour half-life means that after 36 hours, half of the DNP will still be in your body. Plan to sweat your ass of at your job... if you're not in the hospital.


THX for answer, this question intend to be something like test, I hope that you will answer it because I really rate your aknowledge about dnp very high, like those lethal high doses of DNP.

My english language is very bad and thats the way in wich I can make question better, and thats the way I can expekt answer fast because I sad that I was already taken 1000mg...

Sorry for this....

Can you pls tell me which dose you recommend for 3-or 4 days. I cant take it more days in a row because I have job wich requires all day standing and working with peaople, and sweeting for me on something like 400mg dose is something that sweets me out of myself :D


Sorry for this like post one more again, and pls do not take more then 600mg because DNP can kill you...
 
THX for answer, this question intend to be something like test, I hope that you will answer it because I really rate your aknowledge about dnp very high, like those lethal high doses of DNP.

My english language is very bad and thats the way in wich I can make question better, and thats the way I can expekt answer fast because I sad that I was already taken 1000mg...

Sorry for this....

Can you pls tell me which dose you recommend for 3-or 4 days. I cant take it more days in a row because I have job wich requires all day standing and working with peaople, and sweeting for me on something like 400mg dose is something that sweets me out of myself :D


Sorry for this like post one more again, and pls do not take more then 600mg because DNP can kill you...

So you lied about the dose, and now expect him to come in here and help you again? Heh.. good luck bro. Go read the stickies and the successful logs.. Follow the rules and you too can prevent forest fires. 1000mg nuts.. I have a high tolerance and I get great fat loss vs sides at 400mg ED and I work up to it.. I never start at 400.. I do 200 today, 300 tomorrow, 400 the third day and continue there.. because of the 36hr half life..

Yes you feel plenty hot the first two days you stop the DNP..

Damn Conc, am I going to see greater fatloss running it on cycle or after pct?? sort of undecided.. if it will work better on cycle than i'm all for that option this time..
 
I have a question about that girl who died in London:

Even if the hospital had thorough knowledge on DNP (I'm assuming most doctors haven't had to deal with it), could they have done anything to save her? I know that hypothermia can be induced easily, but wouldn't the fever be too high and out of control? I would think that the difference of temperature in the saline solution (or whatever it is they use to bring someone's body temperature down) needed and the heat being released by her body would be so drastic that it would cause problems in itself.

I have incredibly little medical knowledge, I'm just curious how it works. DNP is very interesting.
 
Even if the hospital had thorough knowledge on DNP (I'm assuming most doctors haven't had to deal with it), could they have done anything to save her? I know that hypothermia can be induced easily, but wouldn't the fever be too high and out of control? I would think that the difference of temperature in the saline solution (or whatever it is they use to bring someone's body temperature down) needed and the heat being released by her body would be so drastic that it would cause problems in itself.

I have incredibly little medical knowledge, I'm just curious how it works. DNP is very interesting.
A drug called dantrolene has successfully been used to treat DNP overdose. It doesn't prevent DNP from producing heat, but it does allow the body to release heat more quickly by causing muscle relaxation. This lowers body temperature and prevents a harmful fever.

In the case where it was used successfull, the subject's temperature went from 108 to 104 after using "cooling blankets, fans, and tepid water soaks". However, after dantrolene administration, it went from 104 to 100.8 within only 20 minutes. They then kept it under 100.4 by admniistering dantrolene for the next 12 hours. The subject subsequently recovered and was released.

So to answer your question, yes, it's very likely the hospital could have done something to save her. That doesn't necessarily mean that everyone who overdoses will recover by taking dantrolene, but that dantrolene appears to be a viable treatment for DNP overdose.

Hope that helps,
Conciliator
 
A drug called dantrolene has successfully been used to treat DNP overdose. It doesn't prevent DNP from producing heat, but it does allow the body to release heat more quickly by causing muscle relaxation. This lowers body temperature and prevents a harmful fever.

In the case where it was used successfull, the subject's temperature went from 108 to 104 after using "cooling blankets, fans, and tepid water soaks". However, after dantrolene administration, it went from 104 to 100.8 within only 20 minutes. They then kept it under 100.4 by admniistering dantrolene for the next 12 hours. The subject subsequently recovered and was released.

So to answer your question, yes, it's very likely the hospital could have done something to save her. That doesn't necessarily mean that everyone who overdoses will recover by taking dantrolene, but that dantrolene appears to be a viable treatment for DNP overdose.

Hope that helps,
Conciliator

Not dropping 1000mg in a day also helps. :)
 
OK, started my cycle yesterday. 200mg yesterday and today, then I'll bump to 400mg for 8 or 10 days. Taking a Centrum in the morning and 1 cap of SAN Tight with the first daily dose. I'll check back in with status updates.

Diet is mainly meat and vegetables. One question is this: I read earlier in this thread that fructose is a desirable carb during cycle, but is there any added benefit to minimizing other carbs? I know it affects your energy level, but I've had no problems with energy in previous cycles when using energy supplements. Will I burn more fat with no bread/rice/cereal?

Also, a side note: I've observed more women having medical problems as side effects than men. The majority of posts I've read on various forums about people having severe reactions (allergic or otherwise) from DNP have been from women. My girlfriend also had a bad allergic reaction which sent her to the ER; swelling, hives, etc.

Will report back in 2-3 days. Thanks!
 
Up to 400mg per day, and feeling the heat. Summertime in Florida. I don't mind it much, though. I'm used to sweating during summer... I'd much rather be hot than cold anyway. Some more questions pondered along the way:

-Is there any correlation between how much you sweat and how much fat you burn, other than the relationship between perspiration and dosage?
-Is there a correlation between water intake and fat loss? Since water is the medium in which all metabolic processes take place, does it follow that I'll burn more fat by drinking more water (since the body pretty much uses everything I take in)?
-Wouldn't weight training cause muscle loss while on DNP? Since weight training breaks down muscle fibers (in order to regenerate with protein synthesis), and since the body doesn't have enough energy to build muscle while on DNP, then wouldn't you just be tearing down muscle? Sure, you'd be burning tons of calories, but there are other ways do accomplish this.
-I've noticed that I'm wide awake when I need to go to sleep; I wonder if it's due to residual effects from the SAN Tight I take around 10am, or if it's possible that DNP promotes mental awareness (I typically feel pretty mentally energetic all day), even though it drains you physically.

OK, enough for now. More later.
 
One question is this: I read earlier in this thread that fructose is a desirable carb during cycle, but is there any added benefit to minimizing other carbs? I know it affects your energy level, but I've had no problems with energy in previous cycles when using energy supplements. Will I burn more fat with no bread/rice/cereal?
You will burn more fat if you reduce your carb intake (e.g. no bread/rice/cereal). That's because you're consuming fewer calories and creating a greater caloric deficit. Fat has to make up the difference. However, you can only cut calories so far before the contribution from fat is maxed out and you start to lose muscle. I think the best results will come from cutting calories 500-1000 per day (assumng a low to moderate dose of DNP). If you're cutting calories more aggressively (such as 1000 per day), I'd be sure to take something that helps mobilize fat, like EC or clen.
Also, a side note: I've observed more women having medical problems as side effects than men. The majority of posts I've read on various forums about people having severe reactions (allergic or otherwise) from DNP have been from women. My girlfriend also had a bad allergic reaction which sent her to the ER; swelling, hives, etc.
I don't think women have any greater incidence of side effects than men. Some form of rash seems to occur pretty uniformly in about 15% of DNP users, with a small percentage of that manifesting severe rash/hives (like what happened with your GF). The only exception I see might be with cataracts. In the 1930's there were 164 case reports of cataracts, but only 3 of those cases were in men. That might be simply because the drug was used much more by women than by men. Another possible explanation is the link between cataracts and antioxidant deficiency. More women may have developed cataracts due to smaller diets with insufficient antioxidant intake (such as vitamin C). It's also possible that women just develop them more than men, though I'd bet on the former.
 
You will burn more fat if you reduce your carb intake (e.g. no bread/rice/cereal). That's because you're consuming fewer calories and creating a greater caloric deficit. Fat has to make up the difference. However, you can only cut calories so far before the contribution from fat is maxed out and you start to lose muscle. I think the best results will come from cutting calories 500-1000 per day (assumng a low to moderate dose of DNP). If you're cutting calories more aggressively (such as 1000 per day), I'd be sure to take something that helps mobilize fat, like EC or clen.
I don't think women have any greater incidence of side effects than men. Some form of rash seems to occur pretty uniformly in about 15% of DNP users, with a small percentage of that manifesting severe rash/hives (like what happened with your GF). The only exception I see might be with cataracts. In the 1930's there were 164 case reports of cataracts, but only 3 of those cases were in men. That might be simply because the drug was used much more by women than by men. Another possible explanation is the link between cataracts and antioxidant deficiency. More women may have developed cataracts due to smaller diets with insufficient antioxidant intake (such as vitamin C). It's also possible that women just develop them more than men, though I'd bet on the former.

I'm quoting just so you know I'm talking to you.. 750mg Test E, 300mg Tren A..weekly, along with 400mg of DNP daily.. Whew! This shits melting off by the fucking hour.. I'm about as hot as I feel on 600mg ED..
 
Well I'm about to start a DNP cycle in September, 3-4 weeks on relatively low dosages. So I'd appreciate any comments.

I'm going to start @ 200mg in the mornings for 5 days, and if I feel comfortable increase to 300mg on days 6-21. I did take a look at the regimen.xls file and checked the overall concentrations in my body (I want to keep peak concentrations under 700mg all the time), and therefore I'm going to split the 300mg into 200 in the mornings and 100 in the afternoons. What I always wanted to know, why doesn't every "DNP cycle" thread here include the regimen spreadsheet....I think it helps a lot with controlling progress and avoiding a huge (and possibly dangerous) buildup. What's a safe peak concentration anyway @Conciliator?

Goal is to drop from 16-17%bf to 8-9% (about 15lbs of fat in my case), either in one cycle on or in two.

I'm also doing an E/C stack with a daily dose of 50/400 split into 2-4 smaller ones. Diet will be down from my maintenance of 2700kCal to 1900-2200 (depending on, if I'm working out or not), with probably a 40/40/20 split. I'll try to keep my 3 days in the gym (mostly compounds) and maybe add some cardio. (I rather further reduce calories, than do cardio to be honest)

Supps and antioxidants will remain the same as usual, (I take a bunch that acts anti-inflammatory anyway, due to my multiple sclerosis). I'm considering adding some glycerine to the mix.

It's my first post....but I've been an avid reader of these boards for quite some time.
Thanks for any advice.
 
What's a safe peak concentration anyway @Conciliator?
That's going to vary significantly from person to person. Sensitivity to DNP is something that's very individual. Also, for a given person, sensitivity can change during a long cycle as tolerance develops. A moderate dose for most people is somewhere between 200 and 400 mg/day of an accurately dosed product.
 
What actually happens when someone takes a low carb approach on DNP?
I think most people will feel better on a higher carb intake. But if you function well on low carbs and are on a low carb diet, there's no reason you can't add DNP to it. See how things go. If you feel low on energy, try upping your carb intake. DNP will increase your metabolic rate whether you eat a lot of carbs or not; they're not necessary for DNP to work. However, you'll probably feel better with them in yout diet. You'll have to experiment and find out what works for you as an individual.
 
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