2,4-DiNitroPhenol [DNP]

Heretic

New Member
Credit to the gods that wrote this... :)

HOW TO NOT FUCK UP DNP:

Since some guys have been playing around and disrespecting DNP and then griping to the forums about the painful results, we need to make this VERY specific and VERY correct so that people won't keep jumping for DNP out of curiosity, or without the willpower they need to operate this respondibly. So here are my experienced guidelines to using it the RIGHT way.

FIRST GUIDLINE: Dosing. Use ONLY 200mg a day for the first four days. I don't care that you don't "feel" anything yet and you wanna bump it up. DNP accumulates in the body, and not "feeling" something means NOTHING. It's there, and it's working (the effect on metabolism begins within two hours of the first dose!). Four days will let you test your tolerance: do you have an allergy? Does it give you a rash? etc.
Only after those four days do you bump it up, by 200mg a day. The average dose is 400-600/day, and more than that gets a little severe. A full gram is the highest dose I've heard anyone use. I've used that much, and it's hell. I like to stay around 600 a day, which is HOT but safe and effective. Take caps even hours apart through the day, ending about 4-5 PM.

SECOND GUIDLINE...How to eat on DNP. This is purely personal experience, because some guys like to carb-deplete *before* using DNP (then eat carbs as usual while on), and other guys like a low-carb approach throughout. Both are fine. Using DNP is the only time that fructose is a desireable cutting carb, because it keeps the liver replentished. That reduces lethargy and spares muscle.
Be aware that eating high-carb foods WILL increase the heat sensation within an hour, and last about 2 hours. That means don't eat carbs before bed unless you want those night sweats to be even WORSE.
Personally, I ate whatever the hell I wanted! IHOP, chinese, fajitas...Yes, I burned hot, but I still lost 1.5 pounds every 2 days. Keep protein HIGH for muscles' sake, and try it yourself.

Foods I suggest including:
Blueberry yogurt. Blueberries are excellent antioxidants, and yogurt cultures help with digestive function, gas, and stool consistency (disgustingly soft stools are common during DNP).
Oregano-based foods. Oregano is perhaps one of the most potent antioxidants around,a nd one spoonful counts as a vegetable serving. See this article
Pineapple - I've found that pineapple helps alleviate those "DNP Blues". The fructose helps, and pineapple enzymes aid in protein digestion.
V8 - one 12-ounce can supplies six servings of veggies, concentrated as an excellent source of antioxidants, lycopene, and recovery of electrolytes.
Oatmeal - high-fiber foods are necessary. You'll find out why around, oh, day 5 or so. Trust me.


THIRD GUIDELINE...Supplements and DNP. I suggest:
ECA - DNP is not a stimulant. To keep energy high and aid in fat loss, use an ECA. Some advisors suggest that regular ephedrine is preferable to norephedrine because of the more direct "hit" of energy.
Prohormones - perfectly fine on DNP. I used 1-AD just to help keep strength and muscle up, and it worked fine. No problems here. You won't GROW muscle on DNP, but it'll help with strength and protection.
Obvious stuff - multivitamin, ZMA, etc.
Biotest PowerDrive - No, I'm not pimping Biotest. But PowerDrive is an excellent pre-workout mixture that actually works. Plus it's low-carb (only 15 calories total), so it won't cause carb-heat in the middle of your workout.

Antioxidants - I'm giving my own personal list, and why I use them:
Alpha Lipoic Acid - aids in fat management and blood sugar, and an excellent antioxidant.
Grape seed extract
Syntrax Radox
Green Tea
Inositol - mood enhancement, antioxidant, and muscle support. 1 gram/3x day
Ellagic acid - protects cell DNA/RNA from damage by free radicals, and may even atack cancerous cells. 400mg/twice a day
Fruit antioxidants - beyond-a-century's powder of high-potency natural fruit anti's. 1 gram, 2-3x day.
Trimethylglyceine - antioxidant, helps move fat and blood lipids into the liver and out of the body. 500mg, 2x day.
Vitamins E and C

Supplements NOT to use:
Any medications that suppress energy. No allergy meds, antidepressants, muscle relaxers, or beta blockers. DNP will have you low as it is; don't worsen your body's energy by taking something that suppresses you further.

DRUGS - Sheesh, you'd think I wouldn't have to mention this, but two idiots in particular (right here on this forum) recently affirmed that some people still just don't get it. NO alcohol (not even "moderate"), NO ecstasy, NO GHB, etc. If you don't have the willpower to forego these habits, DNP is not for you.

Syntrax Swole - a personal discovery. I tried Swole while on DNP...once. Two hours of hell, feeling inside-out.

FOURTH GUIDELINE...working out on DNP. Keep lifting short, 30-40 minutes. DNP works very well, causing your body to use 150% or more the calories per action you'd normally use. That means DON'T try to repeat your usual workouts. Drop to moderate weights, 8-12 reps, not to failure, and with plenty of walking rest between sets. You are NOT going to grow muscle on DNP, so don't use your usual heavy routine. Since DNP can cause light-headedness and heat dizzyness, you have my permission to skip squats in favor of leg presses this time.

Cardio is a controversial one. My advice - do NOT do cardio on high doses of DNP (600mg or more). It's dangerous and counterproductive. Below that amount, some cardio is fine, but keep it to 20 minutes and not at full-gallop. Remember, DNP will drain water from your quickly, causing you to leech out minerals, vitamins, and salts. Don't overdo it.

During exercise, consume at least 1 liter of water per 30 minutes of work, whether you're thirsty or not. DNP is evil in the way it blunts thirst, while at the same time doing the cruel trick of bloating your body with water WHILE dehydrating you from water in your organs. MAKE yourself drink. Always folllow DNP exercise with antioxidants, carbs, and this is a good time to use your multivitamin.

Don't feel embarrassed about poor workouts. Just this morjning I did a workout with a whopping nine sets (wimp!) before calling it quits. Listen to your body, and let it tell you when enough's enough; don't guage workouts by what you *usually* can do otherwise.

Here's my research. This is AMAZING! Not only has not a single test found it to be carcinogenic, but test after tyest after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%. The summaries are all right here, friends. Karma me up!

DNP is Ames negative, and does not promote tumors. See for yourself at http://toxnet.nlm.nih.gov/

http://www.epa.gov/ttn/atw/hlthef/dinitrop.html (2,4-Dinitrophenol | Technology Transfer Network Air Toxics Web site | US EPA) reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.

Cyberiron.com reports on halth risks from external exposue. In other words, don?t get it in your eyes, or on your skin if you?re allergic. Pretty elementary stuff.

http://www.ebec2000.com/abstracts/056.htm This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.

Biosource A PDF file about an antidote to DNP.

http://www.boehringer-ingelheim.es/...glesa/cap13.htm finds that DNP did not activate liver enzymes (MAT) associated with liver damage

"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.

"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know?it?s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst results being softened stools and gas).

"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as?2,4-dinitrophenol (DNP)."

"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out?DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure?"


"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.

Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it?s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer?fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.

"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it?s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity?"

"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP?s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.

"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.

"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates?or disrupts?cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.

"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT (good ol? DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect?"

"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide by neutering themselves. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."

"Autocatabolism of surface macromolecules shed by human melanoma cells." Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps melanoma cells die (autocatabolize) while other cells are unaffected.

http://www.geocities.com/byggdegstor/dnpforside - tons of research, including medical studies. Excerpts:

DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation ? 1996 Robert Ames)

Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."

"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."

"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."

"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."

"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."

"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."


Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
 
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Hi again - no worries about the questions :)

I've been training properly, i.e with the pupose of muscle building for just under 3 years - before that I did a lot of liftling with no real purpose & a whole lot of cardio stuff, I used to surf, run, swim, gig row if it involved running around like a mad woman I did it lol[:o)]

because of all the cardio I never had lots of muscle - although I looked quite defined - I weighed around 60kg at 5.5 I'm now 68kg at 5'5 I'm fairly muscular for a girl and although I've defo got more body fat than I'd like (I'm a UK 12) I'm in pretty good shape and am happy to put up with the extra kgs for the sake of building more muscle.

I guess thats how I got interested in the dnp, I like the idea of losing a bit of fat without the muscle (dont we all!) so did loads & loads of research and finally went for it - I agree with you though and think the caps must have been underdosed. I'm really quite excited about capping my own and plan on watching my food intake more carefully this time and also taking before & after measurements to see what can be acheived if I'm smart about it.

I'v never tried aas & have no intention of trying - no disrespect to women who do but I just don't fancy the side effects (sounds silly after dnp but at least I knew I could stop the dnp) + I've no intention of competing etc - I just love training and am still getting a huge kick out of seeing my body change and muscles grow :D

I'm lucky in that I have a fantastic training partner, female, same age & height as me but a whole lot leaner - she's been into BB for 10+ years and really knows her stuff so together we really encourage /push eachother and kick some ass ha ha ha:eek:

I'd love to see more women lifting weights in our local gym but it seems so many are worried about geting bulky etc - they really don't get how much work it takes :confused:

:D:D

Wow surfing, I've been surfing since i was a child. Here's another thing we have in common I'm 5feet6". I would bet i'm the shortest guy on this board:( Have you tried clen or albuterol for fat loss? Those are popular. So your gonna cap your own stuff that sounds interesting, i have a good source for capping supplies etc.. if your interested. Here in Miami i see plenty of women who weight train and are quite muscular and defined...it's nothing out of the norm here.
 
I really got into surfing a good few years back but i don't ever seem to get much better at it - must admit I don't go too often now expecially in the winter as its soo damn cold - ha ha ha I did have this fantastic Idea that maybe after a few dnp caps I could go in and not feel cold but then I remembered th bit about lack of energy & thought better of it [:o)] was a nice idea tho.

Miami sounds much warmer :cool: never been to the States. We have loads of great waves/beaches but the water is always cold! even in the summer its a maximum of maybe 16 degrees - went to Bali last winter and the winter before, sea was a bit dirty but 29 degrees :D way nicer :cool:

Very few women lift weights etc around these parts - lots use the gym machines and do classes etc but thats about it - but then I live in Cornwall which aint exactly a big city so I'm just happy I have such a fantastic traing buddy.

So hows Miami this time of year? I usually try & escape someplace warm for a month or so in Jan/Feb but can't this year so I guess I'll just have to deal with the cold eh

I've never tried clen either - to be honest I've never really had that much of an issue with trying to loose weight - I started using eph as I got anoyed (like most women) with stuborn lower belly fat but I'm not sure if it help'd or not - I then spent 10 weeks in S.E asia & Australia early this year and got led astray lol ended up eating junk & drinking with friends + not training and put on around 7kg of fat!! I did lose alot of it when I got back into my training after returning home and defo have built more muscle but stil am finding the fat harder to shift than I expected - it seems to really like me and wants to stay :mad: I thought about clen etc but its kind of expensive here and theres alot of fake stuff around + I'v heard not so good things about it really affecting your thyroid & causing muscle loss etc?? I should do some proper research I guess.

I stumbled apon dnp quite by accident and must admit was kind of intruiged by the whole idea - I did loads of reseach and was satisfied it was prob no more dangerous than alot of drugs as long as you were super carefull & sensible - after my quite positive experience I'm keen to do a proper cycle and eat better etc and see the results.

Its not a thing I'd keep taking every few months though - I think its a useful tool to shift some fat fairly fast but certainly it shouldn't be depended upon as a way out. I would be concerned about long term damage if used too often.
 
I really got into surfing a good few years back but i don't ever seem to get much better at it - must admit I don't go too often now expecially in the winter as its soo damn cold - ha ha ha I did have this fantastic Idea that maybe after a few dnp caps I could go in and not feel cold but then I remembered th bit about lack of energy & thought better of it [:o)] was a nice idea tho.

Miami sounds much warmer :cool: never been to the States. We have loads of great waves/beaches but the water is always cold! even in the summer its a maximum of maybe 16 degrees - went to Bali last winter and the winter before, sea was a bit dirty but 29 degrees :D way nicer :cool:

Very few women lift weights etc around these parts - lots use the gym machines and do classes etc but thats about it - but then I live in Cornwall which aint exactly a big city so I'm just happy I have such a fantastic traing buddy.

So hows Miami this time of year? I usually try & escape someplace warm for a month or so in Jan/Feb but can't this year so I guess I'll just have to deal with the cold eh

I've never tried clen either - to be honest I've never really had that much of an issue with trying to loose weight - I started using eph as I got anoyed (like most women) with stuborn lower belly fat but I'm not sure if it help'd or not - I then spent 10 weeks in S.E asia & Australia early this year and got led astray lol ended up eating junk & drinking with friends + not training and put on around 7kg of fat!! I did lose alot of it when I got back into my training after returning home and defo have built more muscle but stil am finding the fat harder to shift than I expected - it seems to really like me and wants to stay :mad: I thought about clen etc but its kind of expensive here and theres alot of fake stuff around + I'v heard not so good things about it really affecting your thyroid & causing muscle loss etc?? I should do some proper research I guess.

I stumbled apon dnp quite by accident and must admit was kind of intruiged by the whole idea - I did loads of reseach and was satisfied it was prob no more dangerous than alot of drugs as long as you were super carefull & sensible - after my quite positive experience I'm keen to do a proper cycle and eat better etc and see the results.

Its not a thing I'd keep taking every few months though - I think its a useful tool to shift some fat fairly fast but certainly it shouldn't be depended upon as a way out. I would be concerned about long term damage if used too often.

Winter in Miami so far this year has been 70 to 78 degrees fahrenheit. T3 or cytomel as it's called can affect your thyroid if not used properly or abused. Clenbuterol or albuterol, i prefer the albuterol as it gives me less sides are good fat burners. You can read full profiles of all these compounds on the steroids profile page. Note: the steroids profile page contains lots of info on many products which are not steroids...clen and albu are not steroids, rather they are bronchialdilators. Here is the Albuterol link Albuterol (Salbutamol) Profile . :)
 
Winter in Miami so far this year has been 70 to 78 degrees fahrenheit. T3 or cytomel as it's called can affect your thyroid if not used properly or abused. Clenbuterol or albuterol, i prefer the albuterol as it gives me less sides are good fat burners. You can read full profiles of all these compounds on the steroids profile page. Note: the steroids profile page contains lots of info on many products which are not steroids...clen and albu are not steroids, rather they are bronchialdilators. Here is the Albuterol link Albuterol (Salbutamol) Profile . :)
BTW when we have a large cold front I just use a good wetsuit. :D
 
5feet6". dam you must be one stocky fella

Wow surfing, I've been surfing since i was a child. Here's another thing we have in common I'm 5feet6". I would bet i'm the shortest guy on this board:( Have you tried clen or albuterol for fat loss? Those are popular. So your gonna cap your own stuff that sounds interesting, i have a good source for capping supplies etc.. if your interested. Here in Miami i see plenty of women who weight train and are quite muscular and defined...it's nothing out of the norm here.
 
Yeah, [:o)] Ceazer I am pretty stocky...especially now on this bulking cycle but it's been coming in pretty dry since i keep my sodium intake low. I always seem to keep my waist at 31' or 32'. :)

Man 31 inch wast awesome I went from a 48 in waist to 36in quit powerlifting and started to bodybuild
 
Conciliator,I'd like to get your feedback on using bioperine to increase the potency of D's crstalline caps.

if anyone has anything to offer on this issue,please see these threads which discuss this:

The fomer is just what I posted here on meso and rec'd no response to and the latter is a thread on M&M.Josh on M&M had some good ideas but was unsure of the particulars,which I'm guessing Conciliator probably would as DNP seems to be his speciality.

https://thinksteroids.com/community/threads/134264046

http://www.mindandmuscle.net/forum/index.php?showtopic=36361 (DNP with bioperine - Mind and Muscle Forums)
 
Conciliator,I'd like to get your feedback on using bioperine to increase the potency of D's crstalline caps.

if anyone has anything to offer on this issue,please see these threads which discuss this:

The fomer is just what I posted here on meso and rec'd no response to and the latter is a thread on M&M.Josh on M&M had some good ideas but was unsure of the particulars,which I'm guessing Conciliator probably would as DNP seems to be his speciality.

https://thinksteroids.com/community/threads/134264046

http://www.mindandmuscle.net/forum/index.php?showtopic=36361 (DNP with bioperine - Mind and Muscle Forums)
I responded over at M&M.
 
First post... I've been reading... and reading.. and reading. I have to work and be around people, so I can't be sweating like a pig. I also like to err on the side of caution when trying anything, especially something like this. BUT I have a few questions.

This is really my limiting factor... sweating. I realize I'll be uncomfortable but about how much (I know you can't really generalize) will I be sweating if I take things slow? I was thinking of doing just 200 mg's a day for a week, every other week. Or could I take 200 mg's for three days, then 400 on the fourth, 200 on the fifth, 400 on the sixth, 200 on the seventh and 400 on the eight? I'm going to be ordering the (hopefully legit) pills in about a month and want to make the most of them WHILE still being functional and not dripping wet. What about taking it every other day and doubling the cycle length? I'd like to do this and eat 1,500 cals a day while using ECA and maybe even Clen. I'd ideally like to lose about 15 - 20 pounds over the course of a month instead of 10 pounds in a week. I have to maintain appearances and can't take off time from work. I won't be doing any cardio on my first cycle... it's not that I'm lazy, I just don't' feel comfortable exercising on something like THIS on my first cycle. The only reason I'm going to take ECA and Clen with it is because Dnp doesn't really have any CNS effects, so I feel safe and confident taking those to keep up my energy and help a little, and (hopefully) they won't make me sweat THAT much more.
 
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Silltraining: To answer your question, the effects (including fat loss and sweating) are all dose-dependent. The more you take, the hotter you'll be and the higher your metabolism will be reasied. The less you take, the cooler you'll be and the lower your metabolism will be raised. You can't say how a given individual will respond to a given dose since there's a lot of variation in sensitivity to DNP. Therefore, questions like "how much would I sweat on 200mg per day" are unanswerable. If you're relatively sensitive to DNP, you could sweat a lot. If you have average sensitivity, you'd probably barely feel it. And if you're tolerant to DNP, you probably wouldn't notice it at all. Until you try DNP, though, there's no knowing what your sensitivity is. I'd recommend getting some lower dosed caps (e.g. 100 mg per cap) so that you can fine tune your dose. That way you can to get enough for a good fat burning effect, but not so much that you're sweating too much or have other excessive side effects.

Hope that helps,
Conciliator
 
OK, thank you! Since it's so dose dependent could I do four cycles at half the normal dose and still lose about the same amount of weight as two cycles at the recommended dose? Or is there no way to tell me that info?

I really appreciate the help, by the way. I always thought it was a poison until I read a lot more... it's safer than nicotine lol. Try eating 200 mg's of nicotine... you'll die lol.
 
OK, thank you! Since it's so dose dependent could I do four cycles at half the normal dose and still lose about the same amount of weight as two cycles at the recommended dose? Or is there no way to tell me that info?

I'm obviously not Conciliator but I will say that this approach would work,I've had a sizable amount of trial and error with DNP.

But you would need to score something to keep your thyroid in check,after a month or thereabouts.I suggest SAN's Thyrocuts 2,per Nandi12's (RIP) feedback.

T3 (Synthroid or an RC) is just too catabolic/supressive.
 
I take 200 mcg's of Synthroid everyday. I have for many years. I used to take 250 but my doc lowered the dose to 200 when I lost a lot of weight (but now I'm at that plateau that I can't break... hence why I want DNP lol) My thyroid is more or less nonfunctional anyway so I'll be getting 200 mcg's of T4 every day, DNP or no DNP.
 
OK, thank you! Since it's so dose dependent could I do four cycles at half the normal dose and still lose about the same amount of weight as two cycles at the recommended dose? Or is there no way to tell me that info?
Going twice as long at half the dose should produce a similar effect. Personally, that's how I like to run DNP, at a low dose throughout a cut.
 
But you would need to score something to keep your thyroid in check,after a month or thereabouts.I suggest SAN's Thyrocuts 2,per Nandi12's (RIP) feedback.
Despite popular opinion and a questionable case report, DNP doesn't appear to have any significant effect on thyroid function. I don't think it's something that DNP users even need to worry about. If you'd like me to elaborate on the evidence behind that position, just let me know.
 
Despite popular opinion and a questionable case report, DNP doesn't appear to have any significant effect on thyroid function. I don't think it's something that DNP users even need to worry about. If you'd like me to elaborate on the evidence behind that position, just let me know.

I was more so referring to the fact that extended periods of dieting hinders the thyroid and as I see it,DNP use along with an extended period of having a caloric deficit in place would certainly slow the thyroid.I agree that DNP isn't particularly rough on its own,the time frame is what I'm really going on about.

FWIW,I plan on running DNP til I hit 175,which would have me at about 10% b/f.I'm at 200 ATM so this will take me 2-3 months,largely contingent on how fanatical I am with dieting.With tightly controll;ed refeeds in place and guggul (despite its ugly sides) my thyroid will still not be at optimal output so I plan on a sort of PCT for DNP.

After this period I plan on a run of T2 followed by transdermal -7-keto to avoid rebound from T2 a'la Nandi12 per the link I provided a couple posts above.

But I digress,what I'd really like is to hear back from you on the email I sent you pertaining to the discussion we had over on M&M through PM's.My email is bigredchief@safe-mail.net.....

Also,I'd love to hear your reasoning behind why you think creatine,beta alanine,arginine and cit. mal. would not hinder fat loss from DNP.I'd really like to run creatine and BA (or CM,depending what I have lying around) while on D to stave offsome of the meh-ish drop in work capacity.There was some good discussion on this on M&M a couple years ago.VirtualCyber laid out a reasonable arguement for the use of ATP precursors while on DNP while Loki isad otherwse with a sound approach taken.A bit of a tough call so I decided on Phenogen in place of creatine 9these two are certainly counterproductive as GPA depletes ATP stores) but I can't do this anymore.

http://www.mindandmuscle.net/forum/index.php?showtopic=15340&hl=creatine+inhibits+fat+loss (Creatine not good while on DNP? - Mind and Muscle Forums)

I've been using a Phenogen clone via bulk GPA,salvia m. and GTE as the AMPK activation here is money but endurance and lethargy is hitting me excessively hard on this third DNP/GPA run to the point of me having to drop the latter.

FYI,if you're interested in trying this,you can read the writeup on Phenogen below.

Introducing PhenoGen: Spook Knows Fat Loss

As an aside,I've developed an updated Phenogen,with either a selective or partial PPAR-delta specific agonist.PPAR-delta agonism is looking to be the next big thing,this will be licensed to Live Long for distribution once we (Avant) hammer out what we will be able to source WRT a PPAR-d agonist.I'd be happy to send you a bottle from my own stash once production gets rolling,just LMK.
 
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