2,4-DiNitroPhenol [DNP]

Heretic

New Member
Credit to the gods that wrote this... :)

HOW TO NOT FUCK UP DNP:

Since some guys have been playing around and disrespecting DNP and then griping to the forums about the painful results, we need to make this VERY specific and VERY correct so that people won't keep jumping for DNP out of curiosity, or without the willpower they need to operate this respondibly. So here are my experienced guidelines to using it the RIGHT way.

FIRST GUIDLINE: Dosing. Use ONLY 200mg a day for the first four days. I don't care that you don't "feel" anything yet and you wanna bump it up. DNP accumulates in the body, and not "feeling" something means NOTHING. It's there, and it's working (the effect on metabolism begins within two hours of the first dose!). Four days will let you test your tolerance: do you have an allergy? Does it give you a rash? etc.
Only after those four days do you bump it up, by 200mg a day. The average dose is 400-600/day, and more than that gets a little severe. A full gram is the highest dose I've heard anyone use. I've used that much, and it's hell. I like to stay around 600 a day, which is HOT but safe and effective. Take caps even hours apart through the day, ending about 4-5 PM.

SECOND GUIDLINE...How to eat on DNP. This is purely personal experience, because some guys like to carb-deplete *before* using DNP (then eat carbs as usual while on), and other guys like a low-carb approach throughout. Both are fine. Using DNP is the only time that fructose is a desireable cutting carb, because it keeps the liver replentished. That reduces lethargy and spares muscle.
Be aware that eating high-carb foods WILL increase the heat sensation within an hour, and last about 2 hours. That means don't eat carbs before bed unless you want those night sweats to be even WORSE.
Personally, I ate whatever the hell I wanted! IHOP, chinese, fajitas...Yes, I burned hot, but I still lost 1.5 pounds every 2 days. Keep protein HIGH for muscles' sake, and try it yourself.

Foods I suggest including:
Blueberry yogurt. Blueberries are excellent antioxidants, and yogurt cultures help with digestive function, gas, and stool consistency (disgustingly soft stools are common during DNP).
Oregano-based foods. Oregano is perhaps one of the most potent antioxidants around,a nd one spoonful counts as a vegetable serving. See this article
Pineapple - I've found that pineapple helps alleviate those "DNP Blues". The fructose helps, and pineapple enzymes aid in protein digestion.
V8 - one 12-ounce can supplies six servings of veggies, concentrated as an excellent source of antioxidants, lycopene, and recovery of electrolytes.
Oatmeal - high-fiber foods are necessary. You'll find out why around, oh, day 5 or so. Trust me.


THIRD GUIDELINE...Supplements and DNP. I suggest:
ECA - DNP is not a stimulant. To keep energy high and aid in fat loss, use an ECA. Some advisors suggest that regular ephedrine is preferable to norephedrine because of the more direct "hit" of energy.
Prohormones - perfectly fine on DNP. I used 1-AD just to help keep strength and muscle up, and it worked fine. No problems here. You won't GROW muscle on DNP, but it'll help with strength and protection.
Obvious stuff - multivitamin, ZMA, etc.
Biotest PowerDrive - No, I'm not pimping Biotest. But PowerDrive is an excellent pre-workout mixture that actually works. Plus it's low-carb (only 15 calories total), so it won't cause carb-heat in the middle of your workout.

Antioxidants - I'm giving my own personal list, and why I use them:
Alpha Lipoic Acid - aids in fat management and blood sugar, and an excellent antioxidant.
Grape seed extract
Syntrax Radox
Green Tea
Inositol - mood enhancement, antioxidant, and muscle support. 1 gram/3x day
Ellagic acid - protects cell DNA/RNA from damage by free radicals, and may even atack cancerous cells. 400mg/twice a day
Fruit antioxidants - beyond-a-century's powder of high-potency natural fruit anti's. 1 gram, 2-3x day.
Trimethylglyceine - antioxidant, helps move fat and blood lipids into the liver and out of the body. 500mg, 2x day.
Vitamins E and C

Supplements NOT to use:
Any medications that suppress energy. No allergy meds, antidepressants, muscle relaxers, or beta blockers. DNP will have you low as it is; don't worsen your body's energy by taking something that suppresses you further.

DRUGS - Sheesh, you'd think I wouldn't have to mention this, but two idiots in particular (right here on this forum) recently affirmed that some people still just don't get it. NO alcohol (not even "moderate"), NO ecstasy, NO GHB, etc. If you don't have the willpower to forego these habits, DNP is not for you.

Syntrax Swole - a personal discovery. I tried Swole while on DNP...once. Two hours of hell, feeling inside-out.

FOURTH GUIDELINE...working out on DNP. Keep lifting short, 30-40 minutes. DNP works very well, causing your body to use 150% or more the calories per action you'd normally use. That means DON'T try to repeat your usual workouts. Drop to moderate weights, 8-12 reps, not to failure, and with plenty of walking rest between sets. You are NOT going to grow muscle on DNP, so don't use your usual heavy routine. Since DNP can cause light-headedness and heat dizzyness, you have my permission to skip squats in favor of leg presses this time.

Cardio is a controversial one. My advice - do NOT do cardio on high doses of DNP (600mg or more). It's dangerous and counterproductive. Below that amount, some cardio is fine, but keep it to 20 minutes and not at full-gallop. Remember, DNP will drain water from your quickly, causing you to leech out minerals, vitamins, and salts. Don't overdo it.

During exercise, consume at least 1 liter of water per 30 minutes of work, whether you're thirsty or not. DNP is evil in the way it blunts thirst, while at the same time doing the cruel trick of bloating your body with water WHILE dehydrating you from water in your organs. MAKE yourself drink. Always folllow DNP exercise with antioxidants, carbs, and this is a good time to use your multivitamin.

Don't feel embarrassed about poor workouts. Just this morjning I did a workout with a whopping nine sets (wimp!) before calling it quits. Listen to your body, and let it tell you when enough's enough; don't guage workouts by what you *usually* can do otherwise.

Here's my research. This is AMAZING! Not only has not a single test found it to be carcinogenic, but test after tyest after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%. The summaries are all right here, friends. Karma me up!

DNP is Ames negative, and does not promote tumors. See for yourself at http://toxnet.nlm.nih.gov/

http://www.epa.gov/ttn/atw/hlthef/dinitrop.html (2,4-Dinitrophenol | Technology Transfer Network Air Toxics Web site | US EPA) reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.

Cyberiron.com reports on halth risks from external exposue. In other words, don?t get it in your eyes, or on your skin if you?re allergic. Pretty elementary stuff.

http://www.ebec2000.com/abstracts/056.htm This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.

Biosource A PDF file about an antidote to DNP.

http://www.boehringer-ingelheim.es/...glesa/cap13.htm finds that DNP did not activate liver enzymes (MAT) associated with liver damage

"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.

"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know?it?s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst results being softened stools and gas).

"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as?2,4-dinitrophenol (DNP)."

"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out?DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure?"


"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.

Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it?s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer?fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.

"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it?s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity?"

"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP?s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.

"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.

"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates?or disrupts?cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.

"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT (good ol? DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect?"

"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide by neutering themselves. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."

"Autocatabolism of surface macromolecules shed by human melanoma cells." Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps melanoma cells die (autocatabolize) while other cells are unaffected.

http://www.geocities.com/byggdegstor/dnpforside - tons of research, including medical studies. Excerpts:

DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation ? 1996 Robert Ames)

Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."

"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."

"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."

"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."

"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."

"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."


Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
 
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Dnp is a carcinogen. There’s studies on it causing ovarian cancer in women and a very close friend took it and got ovarian cysts after 2 weeks at 200mg.
Please post evidence of 1) DNP being classified as a carcinogen and 2) studies showing it to cause ovarian cancer in women.

Hint: I know for a fact that both of these things are complete lies because the latest EPA report shows that it is not classified as a carcinogen because there is zero human data to suggest it:
https://www.epa.gov/sites/production/files/2016-09/documents/2-4-dinitrophenol.pdf
 
Please post evidence of 1) DNP being classified as a carcinogen and 2) studies showing it to cause ovarian cancer in women.

Hint: I know for a fact that both of these things are complete lies because the latest EPA report shows that it is not classified as a carcinogen because there is zero human data to suggest it:
https://www.epa.gov/sites/production/files/2016-09/documents/2-4-dinitrophenol.pdf
Damn I swear when I was looking into it a little while ago I read studies on it.
I apologize for the misinformation, however it is a carcinogen in animals, and kills ovaries (google the shit I say, I just read this) And everywhere I’ve read, it is recommended to run TONS of antioxidants with it, so don’t think just because there’s not human studies, it’s not risky. I’m in no way condoning or condemning DNP, I’ve run it a lot and love it personally. But, a close friend got ovarian cysts during her cycle, that she did not have before, and are now a while after going away. Stil 10/10 would reccomend
 
Damn I swear when I was looking into it a little while ago I read studies on it.
I apologize for the misinformation, however it is a carcinogen in animals, and kills ovaries (google the shit I say, I just read this) And everywhere I’ve read, it is recommended to run TONS of antioxidants with it, so don’t think just because there’s not human studies, it’s not risky. I’m in no way condoning or condemning DNP, I’ve run it a lot and love it personally. But, a close friend got ovarian cysts during her cycle, that she did not have before, and are now a while after going away. Stil 10/10 would reccomend
Not carcinogenic in animal models either and believe me, they've looked into it a bunch of times (published and unpublished data). The models I recall, hamsters & rats, either ended up dying because of the high dose or simply getting shredded. Neither males or females developed cancer.

The recommendation to run tons of antioxidants is given my bros who know jackshit about DNP.
DNP, as with most artificial uncouplers, lowers the rate of superoxide production by mitochondria. In other words, it reduces ROS (oxidative stress) and therefore there is no need for an anti-OXIDANT. This is well established in the literature, which is why I'm saying that those bros who recommend tons of antoxidants do indeed know jackshit about the compound:
Comparison of the effect of a mitochondrial uncoupler, 2,4-dinitrophenol and adrenaline on oxygen radical production in the isolated perfused rat l... - PubMed - NCBI
"Tissue ROS level decreased and oxygen uptake increased soon after 2,4-DNP infusion"
The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter spari... - PubMed - NCBI
"Relative to vehicle-treated animals, pretreatment with DNP maintained mitochondrial bioenergetics and significantly decreased reactive oxygen species levels, lipid peroxidation, and protein carbonyl content following spinal cord injury."
Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus. - PubMed - NCBI
"Some of these effects appear to be due to mild mitochondrial uncoupling and prevention of cellular oxidative stress"

We should highlight the risks of DNP, your right, but not the made up bullshit ones. The real risks relate to stuff like peripheral neuropathy, allergic reactions, dying if your a retard, etc. For women specifically, don't take DNP if your pregnant (duh) and be aware of the possible increase in cateract risk (can appear months after the DNP cycle itself was ended).
 
Not carcinogenic in animal models either and believe me, they've looked into it a bunch of times (published and unpublished data). The models I recall, hamsters & rats, either ended up dying because of the high dose or simply getting shredded. Neither males or females developed cancer.

The recommendation to run tons of antioxidants is given my bros who know jackshit about DNP.
DNP, as with most artificial uncouplers, lowers the rate of superoxide production by mitochondria. In other words, it reduces ROS (oxidative stress) and therefore there is no need for an anti-OXIDANT. This is well established in the literature, which is why I'm saying that those bros who recommend tons of antoxidants do indeed know jackshit about the compound:
Comparison of the effect of a mitochondrial uncoupler, 2,4-dinitrophenol and adrenaline on oxygen radical production in the isolated perfused rat l... - PubMed - NCBI
"Tissue ROS level decreased and oxygen uptake increased soon after 2,4-DNP infusion"
The mitochondrial uncoupling agent 2,4-dinitrophenol improves mitochondrial function, attenuates oxidative damage, and increases white matter spari... - PubMed - NCBI
"Relative to vehicle-treated animals, pretreatment with DNP maintained mitochondrial bioenergetics and significantly decreased reactive oxygen species levels, lipid peroxidation, and protein carbonyl content following spinal cord injury."
Novel neuroprotective, neuritogenic and anti-amyloidogenic properties of 2,4-dinitrophenol: the gentle face of Janus. - PubMed - NCBI
"Some of these effects appear to be due to mild mitochondrial uncoupling and prevention of cellular oxidative stress"

We should highlight the risks of DNP, your right, but not the made up bullshit ones. The real risks relate to stuff like peripheral neuropathy, allergic reactions, dying if your a retard, etc. For women specifically, don't take DNP if your pregnant (duh) and be aware of the possible increase in cateract risk (can appear months after the DNP cycle itself was ended).

Interesting about the ROS reduction. Wonder if there's an angle where low dose DNP over an extended period of time (years) would have anti-aging effects? Sounds worthy of research.
 
Dnp is a carcinogen. There’s studies on it causing ovarian cancer in women and a very close friend took it and got ovarian cysts after 2 weeks at 200mg.

I can't imagine a compound that would actually causes cysts to form in two week. I suppose there could be one, but it seems more likely she had the cysts and their discovery coincided with the end of her DNP cycle. Unless, of course, she was scanned right befor the DNP and then again immediately after, which seems very unlikely.
 
Edit : the cost/benefit calculation of buying raw DNP seems quite favorable, huge savings. Unless you kill yourself. :)
This right here... so true:D

I have a Potato peeler that has the perfect scoop size for 200, and I cap each one myself and weigh it. Ghetto but it works hella well. I made this ghetto ass rig and I just watch TV and cap, ill make around 100 caps in 30 minutes. It takes a long ass time but it is better than dying.
Wish I had one of those, I literally spent a whole night measuring out 300mg of creatine on the tip of a spoon, capping individually, and then for the real asanine part of it, dealt with the pain in the ass of breaking up sticky DNP that stained everything, and measured out 200mg individually capped. All in all spent the whole night doing it, and got 50caps. Not as easy as Capmquick made it seem...
 
Anybody know why I can tolerate 600mg of DNP so well. I hear about people being damn near bid ridden at doses as low as 300-400, but 600 just makes me pretty warm and i need to sleep like 9 hours a day. I have DNP from Scorpion, Fertilizer Warehouse and Dinitro all with the same sides at the 600mg. Im 6'3 230lbs and I fluctuate between 13-15%bf. For the life of me I cant understand why it's no big deal.
 
Anybody know why I can tolerate 600mg of DNP so well. I hear about people being damn near bid ridden at doses as low as 300-400, but 600 just makes me pretty warm and i need to sleep like 9 hours a day. I have DNP from Scorpion, Fertilizer Warehouse and Dinitro all with the same sides at the 600mg. Im 6'3 230lbs and I fluctuate between 13-15%bf. For the life of me I cant understand why it's no big deal.

Because your home office and bedroom are inside an igloo?
 
Anybody know why I can tolerate 600mg of DNP so well. I hear about people being damn near bid ridden at doses as low as 300-400, but 600 just makes me pretty warm and i need to sleep like 9 hours a day. I have DNP from Scorpion, Fertilizer Warehouse and Dinitro all with the same sides at the 600mg. Im 6'3 230lbs and I fluctuate between 13-15%bf. For the life of me I cant understand why it's no big deal.

Some people tolerate it very well. I am one of those people. It just means you'll have to tweak things a bit and pay attention to the normal stuff you should be doing on DNP
 
Anybody know why I can tolerate 600mg of DNP so well. I hear about people being damn near bid ridden at doses as low as 300-400, but 600 just makes me pretty warm and i need to sleep like 9 hours a day. I have DNP from Scorpion, Fertilizer Warehouse and Dinitro all with the same sides at the 600mg. Im 6'3 230lbs and I fluctuate between 13-15%bf. For the life of me I cant understand why it's no big deal.
I can do 750 a day pretty good from scorpion but I have to break it up, I did 500mgs in one dose in the morning and shit got a little more intense than I was comfortable with.

Stay away from IA DNP I ran 1200mgs for 7 days and it compared to about 250 mgs from scorpion
 
I can do 750 a day pretty good from scorpion but I have to break it up, I did 500mgs in one dose in the morning and shit got a little more intense than I was comfortable with.

Stay away from IA DNP I ran 1200mgs for 7 days and it compared to about 250 mgs from scorpion

I'm the same but take 750 all at once occasionally from scorpion. I will only do this for one consecutive day then bump to 500 next day. Typically I blast on the weekends. Being on DNP consecutively sucks IMO. After 5 or so days once it builds up i'm miserable. Mood, energy, motivation go down the shitter.

People freak out when you mention taking 1000mg a day of DNP. But the resulting blood levels from a one time dosage is the same as someone taking 400mg a day for 8+ days.

DISCLAIMER: for you safety I don't recommend upping your one time dose more than 100mg each time. And make sure its the same source and same order
 
I'm the same but take 750 all at once occasionally from scorpion. I will only do this for one consecutive day then bump to 500 next day. Typically I blast on the weekends. Being on DNP consecutively sucks IMO. After 5 or so days once it builds up i'm miserable. Mood, energy, motivation go down the shitter.

People freak out when you mention taking 1000mg a day of DNP. But the resulting blood levels from a one time dosage is the same as someone taking 400mg a day for 8+ days.

DISCLAIMER: for you safety I don't recommend upping your one time dose more than 100mg each time. And make sure its the same source and same order

My mood is always good energy is good, the one thing that gets affected on DNP personally from me is my strength I really lose a lot of strength while on once off it comes right back
 
Please post evidence of 1) DNP being classified as a carcinogen and 2) studies showing it to cause ovarian cancer in women.

Hint: I know for a fact that both of these things are complete lies because the latest EPA report shows that it is not classified as a carcinogen because there is zero human data to suggest it:
https://www.epa.gov/sites/production/files/2016-09/documents/2-4-dinitrophenol.pdf

The reason the epa have no carcinagenic evidence in humans is bc it hasnt been studied enough to say either way.

However in animal models its shown to be carcinagenic

2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death

· In animal studies, DNP has been shown to be teratogenic, mutagenic and carcinogenic; developmental and reproductive toxicity has also been reported
 
The reason the epa have no carcinagenic evidence in humans is bc it hasnt been studied enough to say either way.

However in animal models its shown to be carcinagenic
2,4-Dinitrophenol (DNP): A Weight Loss Agent with Significant Acute Toxicity and Risk of Death
· In animal studies, DNP has been shown to be teratogenic, mutagenic and carcinogenic; developmental and reproductive toxicity has also been reported
What an awful review paper. Not an opinion by the way, fact.
To see why, please read the reference they cite for that statement (no.35), which I attached to this post since it isn't available for free: Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats. - PubMed - NCBI

- The authors specifically mention no teratogenicity in the fucking abstract. They repeat this throughout the paper and yet it is conveniently ignored by the paper you quoted:
"These findings indicate that DNP is toxic to the survival and growth of offspring during the pre- and postnatal periods, and has developmental toxicity, but not teratogenicity, at 30 mg/kg bw/day."

-
Developmental toxicity occurred only at 30mg/kg day. A dosage that no human being would be capable of surviving never mind developing any other side effects. Once again, this was completely ignored by your review paper...why? Why only dedicate 1 fucking sentence to this topic when we clearly have more info?

- And to the point at hand, carcinogenicity was not observed in that study. In fact, you won't even find the words "carcinogen" or "cancer" at all in that paper. Let me make it very, very clear: even at 30mg/kg day, none of the rats in that study developed cancer. None.

So we go from a review paper citing a rat study to reality = some authors voicing an opinion. What a drastic shift in the weight of that evidence :)

The lesson here is not to rely on review papers, especially when it comes to polarizing subjects. Dig deeper. Find the original data. Much better approach to research.
 

Attachments

What an awful review paper. Not an opinion by the way, fact.
To see why, please read the reference they cite for that statement (no.35), which I attached to this post since it isn't available for free: Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats. - PubMed - NCBI

- The authors specifically mention no teratogenicity in the fucking abstract. They repeat this throughout the paper and yet it is conveniently ignored by the paper you quoted:
"These findings indicate that DNP is toxic to the survival and growth of offspring during the pre- and postnatal periods, and has developmental toxicity, but not teratogenicity, at 30 mg/kg bw/day."

-
Developmental toxicity occurred only at 30mg/kg day. A dosage that no human being would be capable of surviving never mind developing any other side effects. Once again, this was completely ignored by your review paper...why? Why only dedicate 1 fucking sentence to this topic when we clearly have more info?

- And to the point at hand, carcinogenicity was not observed in that study. In fact, you won't even find the words "carcinogen" or "cancer" at all in that paper. Let me make it very, very clear: even at 30mg/kg day, none of the rats in that study developed cancer. None.

So we go from a review paper citing a rat study to reality = some authors voicing an opinion. What a drastic shift in the weight of that evidence :)

The lesson here is not to rely on review papers, especially when it comes to polarizing subjects. Dig deeper. Find the original data. Much better approach to research.

Awesome reply.
You're right, i didnt dig deep enough.

For years ive avoided dnp based on that! Thank you!!!
 
Zack F, Blaas V, Goos C, Rentsch D, Büttner A. Death within 44 days of 2,4-dinitrophenol intake. International Journal of Legal Medicine 2016;130:1237-41. Death within 44 days of 2,4-dinitrophenol intake

We report the case of a 50-year-old obese man (115 kg body mass at 1.77 m height), who started taking 2,4-dinitrophenol (DNP) for weight reduction 44 days before his death. After 43 days of taking DNP, the man showed signs of intoxication with nausea, vomiting, and attacks of sweating. After admission to a hospital where the man concealed his DNP intake, sinus tachycardia, tachypnea, and general unrest were noted. The patient died 9 h after the onset of those symptoms. Upon autopsy, a yellowing of palms and soles was striking. The initially uncertain cause of death could only be clarified by the forensic toxicological examinations and subsequent police investigations. Finally, the man had a total intake of 12.3 g of DNP in 44 days which is relatively high compared to other lethal DNP intoxications.
 
Ainsworth NP, Vargo EJ, Petroczi A. Being in control? A thematic content analysis of 14 in-depth interviews with 2,4-dinitrophenol users. The International journal on drug policy 2018;52:106-14. http://www.ijdp.org/article/S0955-3959(17)30368-7/abstract

BACKGROUND: 2,4-Dinitrophenol (2,4-DNP) is a compound with multiple industrial purposes. Currently unlicensed for human consumption, it is used by the gym-going population for drastic, short-term body fat loss. Nonetheless, physiological mechanisms can lead to potentially fatal hyperthermia. Reported fatal incidents have caused concern and highlighted the need for intervention.

Understanding decision-making leading to 2,4-DNP use alongside the perceived outgroup attitudes is vital to forming effective harm minimisation policies targeting current and potential users. First-hand accounts from this elusive population are scarce.

METHODS: Fourteen novel and experienced users (13 male, 1 female) were recruited via "snowballing" techniques. Semi-structured interviews were conducted, comprising 28 questions. Thematic content analysis was conducted using 37 codes.

RESULTS: Four characteristic themes emerged:
1. Users considered the Internet to be a crucial multifunctional resource directly impacting their 2,4-DNP use.
2. Users "respected" 2,4-DNP, proactively taking harm reduction measures.
3. Attitudinal polarisation towards 2,4-DNP within the gym-going community was consistent in all accounts.
4. Users perceived outgroup populations to have inherently negative attitudes towards their use.

These themes fell under the all-encompassing theme of "being in control".

CONCLUSION: For the first time, this study offers a rich detail of attitudes toward 2,4-DNP use by giving a collective voice to users. The element of control over every aspect of the users' life appears to be a significant contributor to the successful risk-management of 2,4-DNP use. In the absence of an established safe upper limit and effective regulatory control, education is critical to harm minimisation.
 
Finally, the man had a total intake of 12.3 g of DNP in 44 days which is relatively high compared to other lethal DNP intoxications.

I see that says "intake" which implies that this man too on average 280mg per day. Is that correct? They say that this is "relatively high" compared to other cases in which death resulted.

I recall reading somewhere that DNP is more dangerous for obese people, but I have been unable to find that reference. Has anyone else seen that information?

Hm... I see that for a mere $US 39.95 they will let us see the full article.
 
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