A GH and fat loss protocol (rhGH lipolysis) that is science-based

[Type-IIx]

I bought this book with a discount and still feel like I wasted my money. It's garbage. It's like a paper I would write in college to cover a subject. There are no protocols or amounts or guidelines or synergies for use at all. Nothing to teach you how to best utilize as a bodybuilder or anything. I'll send you my copy if you want. I just found nothing of value in it that I hadn't already heard or read on the forums or YouTube. Very very basic. It should be no more than $5 and that's still generous

Yeah it’s definitely the Reader’s Digest meets Cliff Notes version of anything worth the price. I wouldn’t doubt he fucked it together over a long weekend.

 

[Delux]

This thread has inspired me to add HGH to my diet and recomp regemen so thank you for all the great information.

A few questions that maybe someone has some experience with:

I just did 6 weeks of tesamorelin 2mg/day with Ipamorelin 400mcg/day and I just recently stopped that and started HGH 2iu/day. I want to get to 4iu morning for the lipolysis protocol and 2iu nightly for the nighttime benefits (6 iu a day). I have read I should start at 2iu/day and work my way up increasing by 1iu every 1-2 weeks to be safe. Does anyone know if I can titrate up faster being that I have been using tesamorelin for a while now? Start at maybe 4iu a day and increase from there?

2nd question, I was getting pretty bad injection site reactions from the tesamorelin. Big red itchy bumps that would last for days. Should I expect the same thing with HGH or are people generally just extra sensitive to the secretagogues? I have read a bunch of stuff about people taking CJC and having very bad reactions but I dont seem to really read about these same issues with HGH.

Cheers Everyone

 

[UncleBuns]

This thread has inspired me to add HGH to my diet and recomp regemen so thank you for all the great information.

A few questions that maybe someone has some experience with:

I just did 6 weeks of tesamorelin 2mg/day with Ipamorelin 400mcg/day and I just recently stopped that and started HGH 2iu/day. I want to get to 4iu morning for the lipolysis protocol and 2iu nightly for the nighttime benefits (6 iu a day). I have read I should start at 2iu/day and work my way up increasing by 1iu every 1-2 weeks to be safe. Does anyone know if I can titrate up faster being that I have been using tesamorelin for a while now? Start at maybe 4iu a day and increase from there?

2nd question, I was getting pretty bad injection site reactions from the tesamorelin. Big red itchy bumps that would last for days. Should I expect the same thing with HGH or are people generally just extra sensitive to the secretagogues? I have read a bunch of stuff about people taking CJC and having very bad reactions but I dont seem to really read about these same issues with HGH.

Cheers Everyone

How fast you can increase GH dose is individual. Because you don't know how you will react, the safest bet would be to increase by 0.5 every 2 to 3 weeks or something along those lines. You can increase faster and you might be fine, but if you're unlucky you may get sides that suck like CTS/numb hands, heart rate/rhythm changes, etc. The smart thing to do is to be patient and increase slowly over time. When you find out what is tolerable for you then you can use that information in the future and it's a lot easier.

4iu may cause drowsiness during the day but not everyone experiences that. You might be fine.

Tesa and GH are completely different peptides so there's no reason to believe a reaction to one would cause the reaction from the other. If the issue you have is with the diluent you're using then that's a different story.

 

[Delux]

That makes sense thanks, ill take it slow.

I'm currently using Hospira and I have also used it in the past reconstituting BPC/TB500 and had no issues with reactions. I also had no issues with reactions when I was taking Semorelin/ipamorelin. Im pretty confident for whatever reason I am very sensitive to tesamorelin to a point where it isnt worth continuing its use.

Hoping HGH can give me similar (based on this thread...better) results with less negative sides.

Im guessing the only reason the HGH secretagogue pepties even became popular in the first place was because of the lack of availability of inexpensive and good quality HGH. Now that its so plentiful and easy to access I dont really see much of any reason to use the HGH secretagogue pepties. But maybe there are some case use situations that make them preferrable to straight HGH that I am not aware of.

 

[UncleBuns]

That makes sense thanks, ill take it slow.

I'm currently using Hospira and I have also used it in the past reconstituting BPC/TB500 and had no issues with reactions. I also had no issues with reactions when I was taking Semorelin/ipamorelin. Im pretty confident for whatever reason I am very sensitive to tesamorelin to a point where it isnt worth continuing its use.

Hoping HGH can give me similar (based on this thread...better) results with less negative sides.

Im guessing the only reason the HGH secretagogue pepties even became popular in the first place was because of the lack of availability of inexpensive and good quality HGH. Now that its so plentiful and easy to access I dont really see much of any reason to use the HGH secretagogue pepties. But maybe there are some case use situations that make them preferrable to straight HGH that I am not aware of.

I used GH peptides in the past but found they have a ceiling for effects. GH can be taken far beyond that ceiling. Higher dose GH peps gave me more sides than they were worth. Even 3iu GH is far more effective with much less sides IME.

 

[Type-IIx]

This thread has inspired me to add HGH to my diet and recomp regemen so thank you for all the great information.

A few questions that maybe someone has some experience with:

I just did 6 weeks of tesamorelin 2mg/day with Ipamorelin 400mcg/day and I just recently stopped that and started HGH 2iu/day. I want to get to 4iu morning for the lipolysis protocol and 2iu nightly for the nighttime benefits (6 iu a day). I have read I should start at 2iu/day and work my way up increasing by 1iu every 1-2 weeks to be safe. Does anyone know if I can titrate up faster being that I have been using tesamorelin for a while now? Start at maybe 4iu a day and increase from there?

This is too slow to ramp up IMO, it's an arbitrary long time-frame. Also, since the RAAS (think pulse pressure) is ramped up at each dose increase for about a week, this just continually keeps your pulse pressure high.

Nighttime GH administration serves a different rationale, purpose, or objective than this lipolysis protocol (cutting; fat loss).

2nd question, I was getting pretty bad injection site reactions from the tesamorelin. Big red itchy bumps that would last for days. Should I expect the same thing with HGH or are people generally just extra sensitive to the secretagogues? I have read a bunch of stuff about people taking CJC and having very bad reactions but I dont seem to really read about these same issues with HGH.

Tesamorelin might not be the best choice for you. Localized swelling and pain at the injection site relates to the drug.

Cheers Everyone

Of course bro

 

[BuildABro]

This is too slow to ramp up IMO, it's an arbitrary long time-frame. Also, since the RAAS (think pulse pressure) is ramped up at each dose increase for about a week, this just continually keeps your pulse pressure high.

Nighttime GH administration serves a different rationale, purpose, or objective than this lipolysis protocol (cutting; fat loss).

Tesamorelin might not be the best choice for you. Localized swelling and pain at the injection site relates to the drug.

Of course bro

I just have to say that this is, by an order of magnitude, the most interesting thread I have encountered since I joined Meso. I have some reading to do.

So thanks so much for the knowledge, experience and expertise.

I just run HGH on cycle, but that might need revision moving forward.

 

[malfeasance]

. . . since the RAAS (think pulse pressure) is ramped up at each dose increase for about a week, this just continually keeps your pulse pressure high.

First time I have heard about this. HGH administration messes up this regulatory system, but after roughly a week any blood pressure increase should go back to normal?

What if you are taking an ARB?

 

[Letits now]

Here is a gift for the Holidays from a likely forthcoming book I am considering releasing, titled Bolus: A Science-Based Guide to recombinant human Growth Hormone (rhGH) for the Athlete, Aesthete, and Aging Gym-goer

This protocol is in direct contravention of the commonly touted 3-5x daily injections of rhGH for lipolysis and the use of GH+fasted cardio for fat loss.

rhGH for lipolysis
Author: Type-IIx

Daily exercise:
Morning or daytime bolus ideally 2-3 hr pre-workout
Single large bolus (≥3IU) for lipolysis: [6] showed lipolysis (blood 3-hydroxy-butyrate) was positively correlated to the peak hGH concentration (r=0.65) for the highest dose (6mcg/kg); [40] showed a significant correlation between the peak GH response to exercise and the post-exercise rise in glycerol measured as area under the curve (r= 0.57,p< 0.04). Also, [69] showed that a single s.c. bolus versus two promotes nighttime FFA liberation.

meal post-workout (4-4.5hr post-bolus), see FFA liberation:

View attachment 157904
FFA liberation: FFA liberation follows an oscillating, rhythymic pattern for 24 hr post-bolus (palmitate [glycerol] flux)
- Post-5IU rhGH administration subcutaneous vs. jet-injected

The normal 24-hour pattern of FFAs is characterized by high values prior to a meal and low levels post-meal [68]
[5]
________________________
References:
[5] Verhagen, A., Ebels, J. T., Jonkman, J. H. G., & Dogterom, A. A. (1995). Pharmacokinetics and pharmacodynamics of a single dose of recombinant human growth hormone after subcutaneous administration by jet-injection: comparison with conventional needle-injection. European Journal of Clinical Pharmacology, 49(1-2). doi:10.1007/bf00192361
[6] Hansen, T. K., Gravholt, C. H., Ørskov, H., Rasmussen, M. H., Christiansen, J. S., & Jørgensen, J. O. L. (2002). Dose Dependency of the Pharmacokinetics and Acute Lipolytic Actions of Growth Hormone. The Journal of Clinical Endocrinology & Metabolism, 87(10), 4691–4698. doi:10.1210/jc.2002-020563
[40] Wee, J., Charlton, C., Simpson, H., Jackson, N. C., Shojaee-Moradie, F., Stolinski, M., … Umpleby, A. M. (2005). GH secretion in acute exercise may result in post-exercise lipolysis. Growth Hormone & IGF Research, 15(6), 397–404. doi:10.1016/j.ghir.2005.08.003
[68] Laursen, T., Jergensen, J. O. L., & Chrlstiansen, J. S. (1994). Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults. Clinical Endocrinology, 41(3), 337–343. doi:10.1111/j.1365-2265.1994.tb02554.x
[69] Jørgensen, J. O. L., Møller, J., Møller, N., Lauritzen, T., & Christiansen, J. S. (1990). Pharmacological Aspects of Growth Hormone Replacement Therapy: Route, Frequency and Timing of Administration. Hormone Research, 33(4), 77–82. doi:10.1159/000181589
_______________________
For those interested in the book, its table of contents (so far) is:
- Objective
- Abbreviations
- Research primer: A 'How To' on interpretation of research
- Contraindications
- Skeletal muscle growth and function
- Skeletal muscle: An endocrine organ
- Hypertrophy
- Mechanisms in hypertrophy
- Conclusions regarding skeletal muscle hypertrophy
- Hyperplasia
- Adult myogenesis
- Satellite cells
- Local mIGF-I and Systemic cIGF-I
- Nitrogen balance and reduced AA proteolysis
- Lipolysis
- Mechanisms in lipolytic activity
- Collagen synthesis
- Collagen Type I & Collagen Type III
- Bone density
- Musculotendinous injury recovery and prevention
- Post-immobilization and post-rehabilitation
- Cognitive function
- Anticatabolism
- Cardiorespiratory endurance
- Anaerobic capacity
- Sprint performance
- Metabolic parameters
- LDL reduction
- Anti-aging and rhGH
- Age-related decline in GH
- Studies
- Lipolysis in elderly
- IGFBPs
- IGFBP-1
- IGFBP-2
- IGFBP-3
- IGFBP-4
- IGFBP-5
- IGFBP-6
- Interindividual variation
- IGF-I/IGFBP-3 ratio
- GHBPs
- Genetic polymorphisms
- d3-GHR
- Women and rhGH
- Plot of IGF-I response to rhGH in adult GHD patients by gender
- Dose-response for women vs men
- Cessation
- Blood pressure
- Pulse pressure
- Intracranial hypertension, i.e., headaches
- Obstructive sleep apnea
- Long-term administration
- Strength
- Withdrawal
- Decrement in serum IGF-I
- Effects on thyroid function
- Anthony Roberts' Article "Thyroid Hormone + Growth Hormone – If You Aren’t Using T4 with Your GH, You’re Not Doing It Right"
- Effects on adrenocortical system
- Organ growth
- Pharmacokinetics & Pharmacodynamics
- SubQ serum GH profile
- IM serum GH profile
- Pulsatile serum GH profile
- GH kinetics
- Effects of estradiol-estrogen, obesity
- Effects of testosterone and aromatizable androgens
- Time-course of changes in response to rhGH administration
- Transient negative feedback inhibition
- cIGF-I changes with administration, withdrawal
- Clinical relevance of cIGF-I
- Practical
- Risk-reward balancing
- Dosages and administration
- Conversion of mcg <=> IU
- General instructions for pharmaceutical rhGH preparations
- Specific products and dosages
- Norditropin
- Genotropin
- Serono Serostim
- Humatrope
- Biodenticals
- Cinnatropin, Jintropin, Kigtropin, Hygetropin
- Generics
- Purity variance within a single batch
- French Testing Group
- Practical protocols
- rhGH for lipolysis
- rhGH for hypertrophy
- Primary RT mode drivers of augmented SC fusion
- combined rhGH and Insulin
- rhGH for musculotendinous healing and post-rehabilitation injury recovery

- combined rhGH and rIGF-I
- rhGH for anti-aging
- Permutations based on limited quantity
- Non-rehabilitative usage
- rhGH for anti-aging
- Testing
- Serum IGF-I
- Analytic laboratory quantitative analysis
- rhGH solutions- What is in the vial or pen?
- Antimicrobial preservative agents
- Considerations
- Theoretical
- Dual Effector Hypothesis supersedes the Somatomedin Hypothesis
- Hyperplasia of skeletal muscle
- Molecular signalling
- AR nongenomic pathway
- Modern theory of 22kDa GH binding at the GHR
- Substrate metabolism
- IGF-I, a myokine promoting a local effort for a global effect
- Pathways and natural pulsatile secretion
- β-adrenergic agonists inhibit GH secretion
- Obesity & rhGH
- Gynecomastia
- Glucose metabolism and insulin resistance
- Hyperglycemia
- Metformin
- Downsides of Metformin
- Insulin
- Rapid-acting, -R type
- Slower-acting, -Log type
- Insulin resistance
- TUDCA
- Calcium levels- hypercalcinemia or hypercalciuria
- Edema and water retention
- Tumor growth and risk of carcinogenesis
- Relevant measures
- Natural baseline measures
- GH
- cIGF-I
- Serum T₄
- Monitoring of rhGH course
- HbA1c and blood glucose monitoring
- Interactions with other drugs or exogenous hormones
- AAS
- AAS Effects on IGFBPs and negative inhibition
- Exogenous Testosterone
- Fluoxymesterone
- Stanozolol
- Oxandrolone
- 5α-DHT
- Metformin
- Estrogen
- Alcohol
- Interactions with endogenous hormones
- Thyroid hormones: TSH, T3, T4
- Testosterone
- Prolactin
- Progesterone
- Health conditions that affect rhGH efficacy
- Related
- Growth hormone secretagogues, i.e. "peptides"
- Secretagogues and obesity

Used the search function and couldn’t find it after 20 seconds so I came straight to source. Do you have any write ups on dimer? (%, effects and so on)

 

[Type-IIx]

Used the search function and couldn’t find it after 20 seconds so I came straight to source. Do you have any write ups on dimer? (%, effects and so on)

Sure do! Here’s one Is generic HGH worth taking?

P.S. Love the nick!

 

[Letits now]

Thanks dude

Sure do! Here’s one Is generic HGH worth taking?

P.S. Love the nick!

 

[Ghoul]

That makes sense thanks, ill take it slow.

I'm currently using Hospira and I have also used it in the past reconstituting BPC/TB500 and had no issues with reactions. I also had no issues with reactions when I was taking Semorelin/ipamorelin. Im pretty confident for whatever reason I am very sensitive to tesamorelin to a point where it isnt worth continuing its use.

Hoping HGH can give me similar (based on this thread...better) results with less negative sides.

Im guessing the only reason the HGH secretagogue pepties even became popular in the first place was because of the lack of availability of inexpensive and good quality HGH. Now that its so plentiful and easy to access I dont really see much of any reason to use the HGH secretagogue pepties. But maybe there are some case use situations that make them preferrable to straight HGH that I am not aware of.

FYI, though you're off of Tesa, for anyone coming across your site reaction report, as Type IIx said. it's a common side effect for the drug, listed in Egrifta's pamphlet (the brand name).

It's worth noting Tesa induces a significant immune system reaction, the likely cause of the pain and swelling. This immunogenicity wasn't found to reduce clinical effectiveness in the trials. I found that increasing the rate of dilution to 1mg/.3ml (ie 3ml in a 10mg vial), and filtering using a .2um PES filter resulted in an enormous reduction in site reactions for me. I also noticed, before I started filtering, that with each day that passed after reconstitution, doses from the same vial induced worsening site reactions.

This leads me to suspect large, immune system triggering peptide "aggregates" form quickly in Tesa, and filtering reduces the quantity of them, easing the immune response.

I find the idea of maintaining natural pulsatile release appealing, but for anti-aging and lipolysis, wonder just how far one can go with Tesa. Is there any evidence of higher GH stimulation beyond 2mg?