"From a structural point of view, Semeglutide replaces Ala with Aib at position 8 of the GLP-1 (7-37) chain, replaces Lys with Arg at position 34, and connects Lys at position 26 to an octadecanoic acid fatty chain. Compared with Liraglutide, Semeglutide Chemicalbook has a longer aliphatic chain and increased hydrophobicity, but Semeglutide has been modified with short-chain PEG and its hydrophilicity is greatly enhanced. After modification, PEG can not only bind tightly to albumin, mask the hydrolysis site of DPP-4 enzyme, but also reduce renal excretion, extend biological half-life, and achieve long circulation."
Via Google Translate, you'll just have to take a look.