Chemman's log

[m_ob]

The answer is staring right at you right under neath your nose...So close yet so far...

i'm actually going to try to come off cortef again once i back fill metabolic gaps and dig into the gut deeper to remove the inflammation. I suspect most adrenal insufficent people have hidden inflammation with in the gut once this is removed adrenals should fire back up.. I talked to an ND at gret extense of this and she agrees 100% the body will kick back in.

Sounds like something a hypochondriac would reach for.. Hidden infections despite what the medical professionals say.

 

[hardasnails1973]

Sounds like something a hypochondriac would reach for.. Hidden infections despite what the medical professionals say.

Yes a hypochonriac with 10 different infections with in the intestinal tract that can wreck havoc on HPTA. That is why proper evaluation is needed. I do not just play guessing games with peoples health but have clincal evidence to base protocols on. So you calling lyme disease a hydochondriac disorder, or having a small bacteria overgrowth chasing a ghost that is based upon clincal stool sample test? This is why modern medicine is so behind the times and people get worse instead of getting better. I mean I have suggested a round of flagyl for people that have symptoms of SBO and amazingly they got better. Stepping out of the box and treating the person not just numbers is why success rate elevated and going above and beyond what modern medicine to know. Doctor in latin means "teacher" but unfortunately they do not teach any more.
Pharmacutical in webster dictionary "practicing witch craft" So look when an "MD" is calling me a witch or voo doo doctor they better undertand the true meaning of what they are practicing..

pharmaceutical - Definition of pharmaceutical at YourDictionary.com
Etymology: LL pharmaceuticus < Gr pharmakeutikos < pharmakeuein, to practice witchcraft, use medicine < pharmakon, a poison, medicine

 

[m_ob]

You are aware of what a hypochondriac is, arn't you?

 

[hardasnails1973]

You are aware of what a hypochondriac is, arn't you?

I had one case of this where we ruled out every stinking thing possible and it was finally labeled maniac depression with no biological explanation.


Hypochondriasis (or hypochondria, often referred to as health phobia or health anxiety) refers to an excessive preoccupation or worry about having a serious illness.[1] Often, hypochondria persists even after a physician has evaluated a person and reassured them that their concerns about symptoms do not have an underlying medical basis or, if there is a medical illness, the concerns are far in excess of what is appropriate for the level of disease. Many people suffering from this disorder focus on a particular symptom as the catalyst of their worrying, such as gastro-intestinal problems, palpitations, or muscle fatigue.

The DSM-IV-TR defines this disorder, "Hypochondriasis," as a somatoform disorder[2] and one study has shown it to affect about 3% of the visitors to primary care settings.[3]

Hypochondria is often characterized by fears that minor bodily symptoms may indicate a serious illness, constant self-examination and self-diagnosis, and a preoccupation with one's body. Many individuals with hypochondriasis express doubt and disbelief in the doctors' diagnosis, and report that doctors’ reassurance about an absence of a serious medical condition is unconvincing, or un-lasting. Many hypochondriacs require constant reassurance, either from doctors, family, or friends, and the disorder can become a disabling torment for the individual with hypochondriasis, as well as his or her family and friends. Some hypochondriacal individuals are completely avoidant of any reminder of illness, whereas others are frequent visitors of doctors’ offices. Other hypochondriacs will never speak about their terror, convinced that their fear of having a serious illness will not be taken seriously by those in whom they confide.

 

[m_ob]

I had one case of this where we ruled out every stinking thing possible and it was finally labeled maniac depression with no biological explanation.


Hypochondriasis (or hypochondria, often referred to as health phobia or health anxiety) refers to an excessive preoccupation or worry about having a serious illness.[1] Often, hypochondria persists even after a physician has evaluated a person and reassured them that their concerns about symptoms do not have an underlying medical basis or, if there is a medical illness, the concerns are far in excess of what is appropriate for the level of disease. Many people suffering from this disorder focus on a particular symptom as the catalyst of their worrying, such as gastro-intestinal problems, palpitations, or muscle fatigue.

The DSM-IV-TR defines this disorder, "Hypochondriasis," as a somatoform disorder[2] and one study has shown it to affect about 3% of the visitors to primary care settings.[3]

Hypochondria is often characterized by fears that minor bodily symptoms may indicate a serious illness, constant self-examination and self-diagnosis, and a preoccupation with one's body. Many individuals with hypochondriasis express doubt and disbelief in the doctors' diagnosis, and report that doctors’ reassurance about an absence of a serious medical condition is unconvincing, or un-lasting. Many hypochondriacs require constant reassurance, either from doctors, family, or friends, and the disorder can become a disabling torment for the individual with hypochondriasis, as well as his or her family and friends. Some hypochondriacal individuals are completely avoidant of any reminder of illness, whereas others are frequent visitors of doctors’ offices. Other hypochondriacs will never speak about their terror, convinced that their fear of having a serious illness will not be taken seriously by those in whom they confide.

or reaching for answers which do not exist? cough* hidden gut infections.

 

[hardasnails1973]

or reaching for answers which do not exist? cough* hidden gut infections.

Oh they exist alright 80% of diseae originates in the gut and liver...20 years or more this will be a none fact. The chinese new it 5,000 years ago and treat depression by balancing the liver..They do it by balancing methylation cycle.

One can run all clincal studies they want. People getting well is my main purpose by using cutting edge methods and pushing the envelope to develope new techniques to get resolutions. The kind of cases that walk through my door are ones that dr's are baffled with. I even have dr's contacting me because they are stuck on cases, but want alternative ideas on where to go. I have a my own counsel that I consult with that I trust and value their opinons. They are all well respected MD's as well that are open minded.

 

[flaccido]

Yes a hypochonriac with 10 different infections with in the intestinal tract that can wreck havoc on HPTA. That is why proper evaluation is needed. I do not just play guessing games with peoples health but have clincal evidence to base protocols on. So you calling lyme disease a hydochondriac disorder, or having a small bacteria overgrowth chasing a ghost that is based upon clincal stool sample test? This is why modern medicine is so behind the times and people get worse instead of getting better. I mean I have suggested a round of flagyl for people that have symptoms of SBO and amazingly they got better. Stepping out of the box and treating the person not just numbers is why success rate elevated and going above and beyond what modern medicine to know. Doctor in latin means "teacher" but unfortunately they do not teach any more.
Pharmacutical in webster dictionary "practicing witch craft" So look when an "MD" is calling me a witch or voo doo doctor they better undertand the true meaning of what they are practicing..

pharmaceutical - Definition of pharmaceutical at YourDictionary.com
Etymology: LL pharmaceuticus < Gr pharmakeutikos < pharmakeuein, to practice witchcraft, use medicine < pharmakon, a poison, medicine

I agree with a lot of what you are writing here.

 

[chemman]

Yup still feeling like ass. Hoping to start on the clomid on a week. Low testosterone + exams = major problems.

What I'm wondering is since I've been shut down for soooo long (about 10 months), should my restart involve more than clomid?

I know that clomid can cause negative feedback on the pituitary because it's an estrogen. This is why scally includes tamoxifen in his protocol, so that way you have stimulation of the hypothalamus with clomid... and blocking of estrogen feedback with the tamoxifen. Maybe even some HCG for the balls? This might be excessive, considering they have been receiving some stimulation this whole time, since I never took any AAS.

 

[CubbieBlue]

Yup still feeling like ass. Hoping to start on the clomid on a week. Low testosterone + exams = major problems.

What I'm wondering is since I've been shut down for soooo long (about 10 months), should my restart involve more than clomid?

I know that clomid can cause negative feedback on the pituitary because it's an estrogen. This is why scally includes tamoxifen in his protocol, so that way you have stimulation of the hypothalamus with clomid... and blocking of estrogen feedback with the tamoxifen. Maybe even some HCG for the balls? This might be excessive, considering they have been receiving some stimulation this whole time, since I never took any AAS.

Yeah, this is excessive for you. If the a jumpstart is going to work, the clomid alone should do it.

My opinion.

 

[Fecal McAngry]

Obviously, dump the soy protein...

 

[chemman]

Dumped. Once I realized that all my problems lie in the HPTA and probably started with negative feedback of estrogens, I ditched the estrogen-mimicking soy real quick.

 

[m_ob]

Thank God.

 

[chemman]

I Wonder if this could be related to my case. Adult-onset isolated hypogonadotropic hypogonadism (IHH) might result from an altered central set-point for E-mediated negative feedback The previous statement could be what happened to me from the tribulus.



Department of Endocrinology, Royal Victoria Infirmary and University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, United Kingdom.

OBJECTIVE: Inhibition of pituitary gonadotropin secretion in men by T is principally mediated by aromatization to estrogen (E), which inhibits hypothalamic secretion of GnRH. We hypothesized that adult-onset isolated hypogonadotropic hypogonadism (IHH) might result from an altered central set-point for E-mediated negative feedback. DESIGN AND SETTING: Longitudinal clinical investigation unit-based evaluation of the clinical and biochemical response to E-receptor blockade. PATIENT(S): A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH 1.7 U/L, FSH 2.0 U/L, T 3.5 nmol/L). INTERVENTION(S): Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months. MAIN OUTCOME MEASURE(S): Baseline and stimulated T levels and LH pulsatility; effect on sexual function. RESULT(S): Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S): Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.

 

[m_ob]

That may be the best study ever done on the efficiency of clomiphine. Nice find man, hopefully this will help shine some light on clomid to give it the credit it deserves.

 

[Michael Scally MD]

I Wonder if this could be related to my case. Adult-onset isolated hypogonadotropic hypogonadism (IHH) might result from an altered central set-point for E-mediated negative feedback The previous statement could be what happened to me from the tribulus.



Department of Endocrinology, Royal Victoria Infirmary and University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, United Kingdom.

OBJECTIVE: Inhibition of pituitary gonadotropin secretion in men by T is principally mediated by aromatization to estrogen (E), which inhibits hypothalamic secretion of GnRH. We hypothesized that adult-onset isolated hypogonadotropic hypogonadism (IHH) might result from an altered central set-point for E-mediated negative feedback. DESIGN AND SETTING: Longitudinal clinical investigation unit-based evaluation of the clinical and biochemical response to E-receptor blockade. PATIENT(S): A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH 1.7 U/L, FSH 2.0 U/L, T 3.5 nmol/L). INTERVENTION(S): Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months. MAIN OUTCOME MEASURE(S): Baseline and stimulated T levels and LH pulsatility; effect on sexual function. RESULT(S): Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S): Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.

Here you go - read on.

 

[chemman]

Bad news. The clomid restart ended about as fast as it started. I split the first day's 100mg dose into EOD 25mg doses for a week and then planned on ramping up to 100mg for 6 days instead of 7. I did this to see how I would react to clomid. Unfortunately, within 2 hours of my 4th 25mg dose, I began to have tingling and numbness in my left pinky. Now I have some tingling and slight numbness in both hands and feet. I am hoping that it subsides once the clomid leaves my system, which could take a week or more. This is an unacceptable side effect, as it involves the CNS.

So it's looking like a clomid restart is not a possibility. It really sucks because I can definitely feel it working. My mood is vastly improved already.

Time for TRT I guess. Not the end of the world. I just want my life back at this point. And a life without numb hands and feet.

 

[KSUzachg]

Is it possible this would go away with time?

 

[chemman]

It most likely will go away with time, but I really do not want to mess around with CNS side effects. I'll know next week if it's a temporary issue. But even if it is, I think clomid is not an option for me anymore.

 

[CubbieBlue]

It most likely will go away with time, but I really do not want to mess around with CNS side effects. I'll know next week if it's a temporary issue. But even if it is, I think clomid is not an option for me anymore.

Are you SURE this tingling is from the clomid? I have never heard of anyone suffering this side effect before.

If you are convinced what form of TRT are you going to use?

 

[chemman]

Central Nervous System: Migraine headache, paresthesia, seizure, stroke, syncope

Read more: Clomid Side Effects | Drugs.com

It is a documented side effect. It is rare in comparison to visual and mood disturbances, however.

As for TRT, my preference is shots. Gels are usually a bad choice for many and I have a gf that I don't want to transfer the drug. Also, I will be training a lot and sweating balls living in the southeast. HCG monotherapy is going to make a shitstorm of e2, to which I already know I am sensitive. So I'll try to do a protocol of like 100mg t cyp BW to start. Mix in some HCG low dose every once in a while to keep my nuts from shrinking. Trying to avoid arimidex.

Talked to my doctor already and agreed to go off clomid and that it was not an option.