Compounded Tirz has been vanquished. UGL likely next. Stock up.

Ghoul

Well-known Member
The following is my opinion as to what's just ahead of us in the UGL based drug landscape. It's based on my close observation of the political and business movements likely to affect this market. As with every opinion, feel free to take or discard my advice as you see fit.


Eli Lily has finally succeeded in putting a stake in the heart of compounded copies of their $1000/mo drug. With the amount of money on the line, expect them to turn their attention to Chinese knockoffs.

While Tirz (and all peptides/protein therapeutics except growth hormone) are not controlled substances, legal to purchase from many legitimate chemical suppliers, they are not legal to sell for human use.

One element in the upcoming De Minimus small package crackdown is a requirement that every product intended for consumer use is required to comply with all relevant regulations, including those from the FDA, and the seller must provide documentation proving it.

The TLDR is this requirement is sufficient for customs to stop the importation of pharma compounds being sent to individuals. Anyone who buys India pharma regularly knows the FDA can seize any med, regardless of whether it's a controlled substance or not. You can be sure that Eli and Novo are already lobbying hard to ensure these tools are employed in the new tightening customs regime.

Like all contraband in high demand, it'll still find a way in, but expect it to be much more expensive.

For those who rely on these meds, it would be wise to stock up while it's inexpensive and plentiful, to ride out any potential interruption in supply.

If you can get a prescription, even if your insurance doesn't cover it (and many more do now so it's worth rechecking), because once you drop below the qualification BMI, you'll never be able to get a prescrip. Once on it, you'll be able get "maintenance" prescription renewals even if you're normal weight.

You don't have to fill those prescriptions if you choose to keep using UGL, but it's a good backup in case you can't get UGL. Remember, these *hormones* are intended for indefinite use, and those coming off overwhelmingly return to baseline weight.
 
There's going to be a rush to stock up on all AAS and drugs like reta, terz, sema before these rules go into effect.

The AAS rush is already in motion, numerous raws are completely unavailable, and oils are getting somewhat scarce and more expensive.

There's probobly sufficient raws in the freezers of brewers to meet demand for oils for some time, but even if the factories in China are permitted to start selling raws again, the de minimus crackdown hasn't even begun which I think will have an even bigger impact.

I was hoping it wouldn't impact peptides, since they're not controlled substances, but there's just too much money on the table for pharma not to turn their attention to the flow of GLPs from China, and as a result, all the "little unmarked vials of powder" will come under scrutiny.
 
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I have 9 months compounded, 2-3 years UGL Tirz and Reta and an Ozempic prescription covered by insurance. I’m only using Reta at maintenance doses. Eli Lily can stick it…

I appreciate "Big Pharma" for their work in developing incredible life saving (and quality of life improving meds), an unpopular opinion I know.

But Eli has been disgraceful. At the same time they wanted compounded versions banned by claiming Tirz was no longer in shortage (the loophole that allowed legal copies to be sold), I and others couldn't get our prescriptions filled.

When Sema(wegovy) was in short supply, Novo stopped selling starter doses to make sure they could provide the higher doses for those already on it, and not add more demand until they could ramp up production. A sensible approach to avoid harming existing patients.

When Zepbound went into short supply , Eli stopped selling higher doses, but made sure starter doses were always available, cutting off existing users, knowing they'd just have to wait, to ensure more people got on Zepbound. Despicable. UGL spared a lot of folks with legit prescriptions from suffering a damaging interruption in treatment.
 
I appreciate "Big Pharma" for their work in developing incredible life saving (and quality of life improving meds), an unpopular opinion I know.

But Eli has been disgraceful. At the same time they wanted compounded versions banned by claiming Tirz was no longer in shortage (the loophole that allowed legal copies to be sold), I and others couldn't get our prescriptions filled.

When Sema(wegovy) was in short supply, Novo stopped selling starter doses to make sure they could provide the higher doses for those already on it, and not add more demand until they could ramp up production. A sensible approach to avoid harming existing patients.

When Zepbound went into short supply , Eli stopped selling higher doses, but made sure starter doses were always available, cutting off existing users, knowing they'd just have to wait, to ensure more people got on Zepbound. Despicable. UGL spared a lot of folks with legit prescriptions from suffering a damaging interruption in treatment.
I agree. For those who have access to these drugs it can be life changing and life saving. But compared to Novo, Eli has really been cutthroat in the way they approached controlling access. I am a big fan of capitalism but Eli is complete ruthless.
 
If you've been on PRESCRIPTION Tirzepatide and think you can abstain for 90 days, now is also probably a great time to get into one of the Phase 3 Reta/Tirz studies.

Be honest with the study authors and make sure you meet their requirements, but they will generally accept you as long as you've been off all GLP-1s for at least a quarter. Think of it as a roundabout way of securing your supply for the next 1-2 years.
 
In the meantime, the Dogs Aging Project is putting rapamycin to good use, extending your beloved pets' life span

Speaking of which, @Ghoul

Considering your concerns about the immunogenicity of UGL peptides and given that rapamycin is used as an immunosuppressant, could this combo potentially mitigate some of those problems?

It’s probably worth pointing out that rapa obviously has some other potentially significant benefits as well as drawbacks, particularly for the folks on this forum.
 
Speaking of which, @Ghoul

Considering your concerns about the immunogenicity of UGL peptides and given that rapamycin is used as an immunosuppressant, could this combo potentially mitigate some of those problems?

It’s probably worth pointing out that rapa obviously has some other potentially significant benefits as well as drawbacks, particularly for the folks on this forum.

One major element of immunogenicity is the variation in immune strength among individuals. For instance, patients with AIDS are unlikely to experience immunogenicity problems with protein drugs, compared to a healthy person.

High T reduces the chances of immunogenicity:


So anything that reduces immune response is likely to lower the chances of developing immunity to peptides.
 
What
The following is my opinion as to what's just ahead of us in the UGL based drug landscape. It's based on my close observation of the political and business movements likely to affect this market. As with every opinion, feel free to take or discard my advice as you see fit.


Eli Lily has finally succeeded in putting a stake in the heart of compounded copies of their $1000/mo drug. With the amount of money on the line, expect them to turn their attention to Chinese knockoffs.

While Tirz (and all peptides/protein therapeutics except growth hormone) are not controlled substances, legal to purchase from many legitimate chemical suppliers, they are not legal to sell for human use.

One element in the upcoming De Minimus small package crackdown is a requirement that every product intended for consumer use is required to comply with all relevant regulations, including those from the FDA, and the seller must provide documentation proving it.

The TLDR is this requirement is sufficient for customs to stop the importation of pharma compounds being sent to individuals. Anyone who buys India pharma regularly knows the FDA can seize any med, regardless of whether it's a controlled substance or not. You can be sure that Eli and Novo are already lobbying hard to ensure these tools are employed in the new tightening customs regime.

Like all contraband in high demand, it'll still find a way in, but expect it to be much more expensive.

For those who rely on these meds, it would be wise to stock up while it's inexpensive and plentiful, to ride out any potential interruption in supply.

If you can get a prescription, even if your insurance doesn't cover it (and many more do now so it's worth rechecking), because once you drop below the qualification BMI, you'll never be able to get a prescrip. Once on it, you'll be able get "maintenance" prescription renewals even if you're normal weight.

You don't have to fill those prescriptions if you choose to keep using UGL, but it's a good backup in case you can't get UGL. Remember, these *hormones* are intended for indefinite use, and those coming off overwhelmingly return to baseline weight.
What do you mean? Of course my t shirt package complies with all regulations.
 
One major element of immunogenicity is the variation in immune strength among individuals. For instance, patients with AIDS are unlikely to experience immunogenicity problems with protein drugs, compared to a healthy person.

High T reduces the chances of immunogenicity:


So anything that reduces immune response is likely to lower the chances of developing immunity to peptides.
So blast t for harm reduction, got it. Do AAS also do harm reduction by any chance?
 
In the meantime, the Dogs Aging Project is putting rapamycin to good use, extending your beloved pets' life span

I never cease to be amazed at how many drugs I’ve never heard of. lol. Just searched up Rapamycin, which of course popped up tons of places to buy it, and now have another rabbit hole to go down.
 
Go figure.

Soon as I figure out life changing peptides and AAS for me and wife, it gets ruined.

Fun while it lasted, I guess

Well don't sit there helpless. Grab a year or two's worth to ride out any potential interruption in supply. I'm sure GLPs will still be available, though how easily and at what cost is another matter.
 
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