The use of multiple drug approaches to effect HPTA restart in hypogonadal situations generated by AAS usage actually has a long history. Numerous doctor have used various combinations in that regard, so this is no big deal.
While this concept will work "sometimes" (not always) with hypogonadism generated by AAS usage in younger males (teens to late 30s), what about AAS-induced hypogonadism in older males? Yes, their "normal" production may return, only to discover that their normal levels are now "sub optimal" (possibly in the 300 - 400 range - as an example - while their optimale levels could be at 700 - 900 levels). So once again, some form of Test administration via LEGAL hormone replacement therapy (TRT) becomes a necessary consideration.
And of course none of this is of any use whatsoever for the hypogonadal male who has become hypogonadal through primary hypogonadal causes or who has become hypogonadal through the "male menopause" (i.e., andropause) process generally related to aging... and unfortunately that "aging process" may affect males as early as their 40s whiole others not until their 60s or so. Having my HPTA restored to "normal" production, only to discover that my now "normal production" of Total T is around 320 (or 400 or whatever other low normal, sub optimal level) is simply meaningless.
Anyway, one of the protocols advocated using multiple drug approaches to reversing HPTA dysfunction in AAS-induced hypogonadism can be located here:
http://www.basskilleronline.com/hpta_reversal.html
While I cannot find the title of this particular study, it is clearly a legitimate medical study (though involving only a small number of patients and no control subjects). It also cites numerous references. BTW, if someone knows - or can find - the name of this study (and date), I would appreciate it. From the cited references, my belief is that this study was done around 2001 or so... Also I believe that it was likely an overseas study (England? Australia?)
I also have some questions about just what the medical license revocation was for in the above post (Mike, asih.net)... without reviewing the whole site - which I simply don't have the desire to do, as it appears that one would need to dig through all kinds of twisted logic and meaningless drivel immaterial to the presented complaint... But what I did notice, right off the bat was the following LARGE posting on the front page of the indicated web site:
It seems to me that the medical license revocation was NOT for treating AAS-induced hypogonadism, but for the illegal prescription of anabolic steroids. In fact, I wonder why the Texas Medical Board didn't turn over their files to enforcement authorities for prosecution of what seems to me to be felonious conduct under Federal law.
But then that's just my opinion....
While this concept will work "sometimes" (not always) with hypogonadism generated by AAS usage in younger males (teens to late 30s), what about AAS-induced hypogonadism in older males? Yes, their "normal" production may return, only to discover that their normal levels are now "sub optimal" (possibly in the 300 - 400 range - as an example - while their optimale levels could be at 700 - 900 levels). So once again, some form of Test administration via LEGAL hormone replacement therapy (TRT) becomes a necessary consideration.
And of course none of this is of any use whatsoever for the hypogonadal male who has become hypogonadal through primary hypogonadal causes or who has become hypogonadal through the "male menopause" (i.e., andropause) process generally related to aging... and unfortunately that "aging process" may affect males as early as their 40s whiole others not until their 60s or so. Having my HPTA restored to "normal" production, only to discover that my now "normal production" of Total T is around 320 (or 400 or whatever other low normal, sub optimal level) is simply meaningless.
Anyway, one of the protocols advocated using multiple drug approaches to reversing HPTA dysfunction in AAS-induced hypogonadism can be located here:
http://www.basskilleronline.com/hpta_reversal.html
...AAS has been shown to induce hypogonadotropic hypogonadism in adult males. The medical literature is conflicting in the reports of spontaneous return and long-term suppression of gonadal suppression post AAS usage. This observational study documents the treatment protocol of HCG, clomiphene citrate, and tamoxifen in returning hormonal function to normal post AAS usage. Design: Five HIV-negative males age 27-49, weighing 77-100 kg, with serum total testosterone levels below 240 ng/dL and luteinizing hormone (LH) levels below 1.5 mIU/mL were considered for this observational study. All five patients were administered the treatment protocol.
Treatment consisted of combination therapy which included concurrent administration of (a) Human Chorionic Gonadotropin, (b) Clomiphene Citrate and (c) Tamoxifen Citrate for a standard duration of 45 days. This protocol was repeated with every patient until serum LH and total testosterone values reached normal ranges... All five patients were considered eugonadal by normal laboratory reference ranges by the conclusion of treatment. Average serum total testosterone rose from 98.2 to 692.8 ng/dL (p<.001) while the average serum LH rose from an average undetectable value of less than 1.0 to 7.92 mIU/mL (p<.0008).
Conclusions: Although the treatment protocol of HCG, clomiphene citrate, and tamoxifen proved beneficial in reversing AAS induced hypogonadotropic hypogonadism, future controlled studies need to be performed to confirm the beneficial effects of this combined pharmacotherapy in returning HPGA functioning to normal.
While we believe that the treatment protocol was effective in returning normal hormonal function to these men, the lack of randomization or a control group leaves room for speculation. Although cases of spontaneous return to eugonadism with no medicinal intervention have been published, these reports documented durations anywhere from 6-18 months before normal hormone status was achieved (Gazvani et al, 1997; Wu et al, 1996). If the alternative treatment modality described herein can reverse suppressed gonadotropin production and AAS associated side effects much sooner than non-treatment, further evaluation of this therapy should continue.
While I cannot find the title of this particular study, it is clearly a legitimate medical study (though involving only a small number of patients and no control subjects). It also cites numerous references. BTW, if someone knows - or can find - the name of this study (and date), I would appreciate it. From the cited references, my belief is that this study was done around 2001 or so... Also I believe that it was likely an overseas study (England? Australia?)
I also have some questions about just what the medical license revocation was for in the above post (Mike, asih.net)... without reviewing the whole site - which I simply don't have the desire to do, as it appears that one would need to dig through all kinds of twisted logic and meaningless drivel immaterial to the presented complaint... But what I did notice, right off the bat was the following LARGE posting on the front page of the indicated web site:
Finding of Fact #18. Dr. Scally administered anabolic steroids to M.W., J.S., J.M., T.W., J.B., J.Bi, S.L., and S.D. for non-therapeutic reasons in violation of the MPA.
Finding of Fact #19. Dr. Scally administered Schedule III anabolic steroids to M.W., J.S., J.M., T.W., J.B., J.Bi, S.L., and S.D. for purposes of bodybuilding in. violation of the Texas Health and Safety Code, thereby violating the MPA.
It seems to me that the medical license revocation was NOT for treating AAS-induced hypogonadism, but for the illegal prescription of anabolic steroids. In fact, I wonder why the Texas Medical Board didn't turn over their files to enforcement authorities for prosecution of what seems to me to be felonious conduct under Federal law.
But then that's just my opinion....