Donepezil for bodybuilding-strongest contractions in my life

[Bradybomb]

I’ve been taking the Alzheimer’s drug donepezil for its nootropic and memory benefits but I’ve noticed something interesting change during my workouts. I am having the strongest muscle contractions of my life.
Donepezil is an acetylcholinesterase inhibitor which means it inhibits what breaks down acetylcholine, a neurotransmitter responsible for memory and rem sleep etc, but also plays a huge role in muscle contraction.
This has led me to research more into donepezil and I have found it has been shown to increase many growth factors and also differentiate satellite cells.
I think this medicine could be very helpful in bodybuilding or even powerlifting for learning the mechanics of a movement.
If you decide to experiment with this medicine be careful and start low. Last time I was using this at the maximum therapeutic Alzheimer’s dose 20mg I tore my pec on the concentric (positive) due to such strong contractions. You may also notice muscles twitching, excessive stimulation, and GI issues. But even at 5mg I am noticing the positives again.

 

[Bradybomb]

@Type-IIx thoughts?

 

[Liter O' Test]

im gonna abuse the shit out of this
@Ghoul

 

[Juicedhead]

Have you noticed Gaines from it ?

 

[eery]

Wouldnt huperzine A do that as well?

 

[Ghoul]

im gonna abuse the shit out of this
@Ghoul

Dalfampradine came to my attention for its cognitive enhancement effects. However, it improves nerve signal transmission everywhere in the body, boosting speed and strength of nerve impulses to muscles.

It makes me wonder is this compound is an overlooked PED,


View: https://youtu.be/MZf4k516NgQ

How Myelination Can Make You a Better Athlete

Practice it wrong and you get good at doing it wrong. The key to making hard things easy lies in myelination, the body’s response to repeated nerve firings.

uphillathlete.com

Impact of extended-release dalfampridine on walking ability in patients with multiple sclerosis - PMC

Dalfampridine extended release (ER) 10 mg is an oral tablet form of the potassium (K+) channel-blocking compounded dalfampridine, also known as fampridine, and chemically 4-aminopyridine or 4-AP, which received regulatory approval in the United ...

pmc.ncbi.nlm.nih.gov

 

[Liter O' Test]

I’ve been taking the Alzheimer’s drug donepezil for its nootropic and memory benefits but I’ve noticed something interesting change during my workouts. I am having the strongest muscle contractions of my life.
Donepezil is an acetylcholinesterase inhibitor which means it inhibits what breaks down acetylcholine, a neurotransmitter responsible for memory and rem sleep etc, but also plays a huge role in muscle contraction.
This has led me to research more into donepezil and I have found it has been shown to increase many growth factors and also differentiate satellite cells.
I think this medicine could be very helpful in bodybuilding or even powerlifting for learning the mechanics of a movement.
If you decide to experiment with this medicine be careful and start low. Last time I was using this at the maximum therapeutic Alzheimer’s dose 20mg I tore my pec on the concentric (positive) due to such strong contractions. You may also notice muscles twitching, excessive stimulation, and GI issues. But even at 5mg I am noticing the positives again.

can you provide me with more information?

how long have you been taking this and at what dosages and gear dosages?
When did you first notice the effects and attribute it to donepezil?


How has it affected your cognition/mood/behavior?
What prompted you to start taking it?
Do you take this everyday? I notice the half life is long.

I have nerve damage so I'm always looking to improve it

 

[egruberman]

I'm definitely curious. Especially since I just received my complete genetic sequencing, which I'll post about soon and apparently am at risk for Alzheimer's.

 

[rexy]

PCT 24x7 sell it in 10mg tabs, so at least one source here has Donepezil - I might pick some up when I place an order early Jan.

 

[Ghoul]

PCT 24x7 sell it in 10mg tabs, so at least one source here has Donepezil - I might pick some up when I place an order early Jan.

Dalfampradine 10mg also available on request, sold as "Dalstep" from Sun Pharma.

 

[rexy]

Dalfampradine 10mg also available on request, sold as "Dalstep" from Sun Pharma.

Thanks for that. I looked for it and didn't see it so that's helpful to know.

 

[eery]

Do we know what the potential negative side effects are acutely and longterm?

 

[Mayne]

Yea started on 5mg maybe coincidentally still calves now cramped waking up how long did you need to notice contraction strength change

 

[iris]

Another one for Alzheimer that is being trialled where I am is hydromethylthionine mesylate, hmtm.
Probably not good for your body building purposes but hopefully helpful to the many people who suffer with the awful memory loss related to this disease.

 

[iris]

Do we know what the potential negative side effects are acutely and longterm?

This.
I guess he has volunteered to be Meso's guinea pig.

 

[rexy]

Yea started on 5mg maybe coincidentally still calves now cramped waking up how long did you need to notice contraction strength change

Potential Impact on Muscular Side Effects:

• While donepezil doesn't specifically target muscle contraction in the same way that muscle relaxants or stimulants might, increasing acetylcholine levels can sometimes result in side effects such as muscle cramps or tremors. These side effects are generally mild and vary from person to person.
  
  
• Donepezil can also have side effects like muscle weakness, particularly at higher doses or in individuals with certain underlying conditions (e.g., myasthenia gravis, a condition where the body's immune system interferes with acetylcholine receptors, impairing neuromuscular transmission).
  
  
• While donepezil increases the level of acetylcholine, which is involved in muscle contraction, it is not typically prescribed for the purpose of enhancing muscular contractions. In fact, it is more often associated with muscle cramps or weakness as a side effect.

 

[Ghoul]

Meanwhile, for dalfampridine

-A significant increase in leg strength was observed in dalfampridine ER responders compared with subjects in the placebo group.

-The drug is thought to act by restoring conduction in focally demyelinated axons and by enhancing neurotransmission, thereby leading to improved neurological function.

- benefits revealed on clinical examination and by clinical experience but not necessarily amenable to, or captured in, formal clinical trial protocols. These include improvements in endurance or fatigability, visual acuity, bladder/bowel/sexual dysfunction. Improvements in mental sharpness, problem solving and reading comprehension have also been reported anecdotally. Some experimental support for these findings has been noted.

-The drug is well tolerated by patients

Impact of extended-release dalfampridine on walking ability in patient | NDT

Impact of extended-release dalfampridine on walking ability in patients with multiple sclerosis Keith C HayesDepartment of Physical Medicine and Rehabilitation, The University of Western Ontario, London, ON, CanadaAbstract: Dalfampridine extended release (ER) 10 mg is an oral tablet form of the...

www.dovepress.com

 

[rexy]

Meanwhile, for dalfampridine

-A significant increase in leg strength was observed in dalfampridine ER responders compared with subjects in the placebo group.

-The drug is thought to act by restoring conduction in focally demyelinated axons and by enhancing neurotransmission, thereby leading to improved neurological function.

- benefits revealed on clinical examination and by clinical experience but not necessarily amenable to, or captured in, formal clinical trial protocols. These include improvements in endurance or fatigability, visual acuity, bladder/bowel/sexual dysfunction. Improvements in mental sharpness, problem solving and reading comprehension have also been reported anecdotally. Some experimental support for these findings has been noted.

-The drug is well tolerated by patients

Impact of extended-release dalfampridine on walking ability in patient | NDT

Impact of extended-release dalfampridine on walking ability in patients with multiple sclerosis Keith C HayesDepartment of Physical Medicine and Rehabilitation, The University of Western Ontario, London, ON, CanadaAbstract: Dalfampridine extended release (ER) 10 mg is an oral tablet form of the...

www.dovepress.com

It does seem to be the better choice; the question is how much of the effect transfers to people without MS.

dalfampridine can have an impact on muscular contractions, but its effect is indirect through the nervous system, rather than directly on the muscles themselves.

• Dalfampridine is a potassium channel blocker. In people with multiple sclerosis (MS), the nerve fibers (axons) are often damaged, and this damage can slow down or block the transmission of nerve signals. This affects the communication between the brain and muscles, leading to symptoms like weakness, poor coordination, and difficulty walking.
  
  
• Dalfampridine works by blocking certain potassium channels in the nerve cells, which helps increase the conduction of nerve impulses across damaged areas of the nerve fibers. This, in turn, can improve the timing and strength of muscular contractions by facilitating more efficient communication between the nervous system and muscles.
  
  
• Improved muscle control: For people with MS, the result is often a better ability to coordinate and activate muscles, which can lead to improvements in walking speed, stability, and overall mobility. However, the effect is not on the muscles directly but on the nerve pathways that control them.

It's important to note that dalfampridine doesn't increase muscle strength itself or directly improve muscle function (like in cases of muscle weakness due to other causes). It primarily improves the efficiency of nerve signal transmission, which may help improve motor control in people with MS.

So, while it doesn't have a direct impact on muscular contractions (like a muscle stimulant would), it helps optimize the nerve-to-muscle communication, which can result in better control of muscle contractions in certain patients.

 

[Ghoul]

It does seem to be the better choice; the question is how much of the effect transfers to people without MS.

dalfampridine can have an impact on muscular contractions, but its effect is indirect through the nervous system, rather than directly on the muscles themselves.

• Dalfampridine is a potassium channel blocker. In people with multiple sclerosis (MS), the nerve fibers (axons) are often damaged, and this damage can slow down or block the transmission of nerve signals. This affects the communication between the brain and muscles, leading to symptoms like weakness, poor coordination, and difficulty walking.
  
  
• Dalfampridine works by blocking certain potassium channels in the nerve cells, which helps increase the conduction of nerve impulses across damaged areas of the nerve fibers. This, in turn, can improve the timing and strength of muscular contractions by facilitating more efficient communication between the nervous system and muscles.
  
  
• Improved muscle control: For people with MS, the result is often a better ability to coordinate and activate muscles, which can lead to improvements in walking speed, stability, and overall mobility. However, the effect is not on the muscles directly but on the nerve pathways that control them.

It's important to note that dalfampridine doesn't increase muscle strength itself or directly improve muscle function (like in cases of muscle weakness due to other causes). It primarily improves the efficiency of nerve signal transmission, which may help improve motor control in people with MS.

So, while it doesn't have a direct impact on muscular contractions (like a muscle stimulant would), it helps optimize the nerve-to-muscle communication, which can result in better control of muscle contractions in certain patients.

For years medical studies have used walking pace as measure of general vitality in aging males.

It makes some sense now, as a loss of myelin is associated with aging. This slows muscle (as well as sensory and cognition) response, and is a factor in the muscle loss process (sarcopenia) that begins in the 30s.

It's so hard to get approval for testing drugs on healthy subjects, but some college students recently given it for 3 days showed cognitive improvement. Too bad they haven't experimented further with it. As long as you stay below the seizure dose (which is quite high), it has an excellent safety profile.

The main argument against it when it was approved 20 years ago was cost/benefit ratio. Started at $14,000 a year. Now a daily dose with a generic is under $250/year.