MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
PissedPajamas
Member
Has anyone combined lantus and semaglutide? Diabetics do it often but I’m wondering how that could affect normal people like us
Rido
Subscriber
I haven't seen too much of combining semaglutide and lantus in T2DM.
I would say start slow though.
PissedPajamas
Member
Semaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial - PubMed
Semaglutide, added to basal insulin, significantly reduced HbA1c and body weight in patients with uncontrolled T2D vs placebo.
pubmed.ncbi.nlm.nih.gov
You can find a few of these studies if you just type “GLP-1 and basal insulin” in google. Lots of info but not directed at the bodybuilder pop
Was looking to use semaglutide while on vacation to control my hunger while eating off plan on my massing phase. Running lantus as a basal insulin at 15iu’s daily just to keep BG down while on higher calories
Rido
Subscriber
I guess I haven't seen this in practice with a dm2 patientSemaglutide Added to Basal Insulin in Type 2 Diabetes (SUSTAIN 5): A Randomized, Controlled Trial - PubMed
Semaglutide, added to basal insulin, significantly reduced HbA1c and body weight in patients with uncontrolled T2D vs placebo.
You can find a few of these studies if you just type “GLP-1 and basal insulin” in google. Lots of info but not directed at the bodybuilder pop
Was looking to use semaglutide while on vacation to control my hunger while eating off plan on my massing phase. Running lantus as a basal insulin at 15iu’s daily just to keep BG down while on higher calories
semaglutide is good enough to control BG tbh.
If its good enough with actual diabetes. shouldnt be necessary for you.
why not just bring a blood sugar monitor to see if it is even necessary?
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HB_22
Well-known Member
Risk of hypoglycemia was greater than with one of them alone. So keep that in mind.
PissedPajamas
Member
Using sema for the appetite control honestly. Lantus already keeps my bg around 85 so I’m not looking for the BG control from sema, just the appetite suppression. Wondering if this is even worth it and I wouldn’t be better off with bringing ephedra instead
Rido
Subscriber
I understand that. But the primary function of it is blood sugar control by increased insulin secretion. Your body autoregulates with lantus/semaglutide to keep your BG in a healthy range.
Would your BG still be in a controlled range of 70-100 on semaglutide alone? Most likely.
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LooseGoose
New Member
Thanks for this. I will be going on sema once it arrives from QSC.
I am currently on 200mg a week of test-c m/w/f injected in the morning.
What would the ratio be for the 4mg vials?
Please let me know if the below is correct:
2ml / 4mg - inject 0.1ml = 0.2mg
Do you recommend injections at the same time as the test and which day?
Captainpotatohead
Member
Anyone else gone from terzepetide to semaglutide? Was previously running 5mg terzepetide but wanted to try semag … first week and I’ve injected 0.5mg and 1mg on two occasions and I’m still hungry all the time ?? I couldn’t even look at food on terzepetide !!
What's led you to that conclusion?
Also, what's the latest in the day that you've personally used liraglutide? Did you ever experiment with using it around 10am-noon? Wondering if using it that way would have more effect on blunting appetite at night.
Same experience for me. I went the other way though. Now sema does 0 for me
HB_22
Well-known Member
My own experience.
I always took it right after waking up in the morning. I honestly don’t see the point in blunting appetite at night?
Because if your like me you can’t stop eating at night.
Wasn't calling you out or trying to be argumentative lol. I was asking what your personal experience with the separate drugs has been. I rarely read accounts from guys that have used both the short and long acting versions. Sorry for being unclear.
Yes. Had to switch to tirzepitide to feel the same effects 5mg for 4 or so weeks after 2.4 full dose of sema for 4 weeks or so. Now 10 mg works for me
HB_22
Well-known Member
No it's fine. I think I have to correct that post of mine (the one you quoted before) a little. If I had to make a list, I would put them in the following order.
From strongest to weakest appetite suppressor:
1.) Liraglutide / Tirzepatide (kinda equal here)
2.) Semaglutide
From least to most side effects:
1.) Tirzepatide
2.) Semaglutide
3.) Liraglutide
As we know appetite suppression is a side effect of these drugs and I personally can say that liraglutide does have the worst side effect profile of them all, so it kinda makes sense that it does have a very strong effect on appetite suppression. While I only had really annoying episdoes of acid burps with semaglutide and tirzepatide but nothing else, it was completely different with liraglutide. It gave me a shitload of sides, like increased rhr by +5-10 beats and also irregular beats, I had an insane lethargic feeling, had low energy levels to the point where I only left the couch to train and that was it because I couldn’t fucking move lol. I also had a vomitting feeling on liraglutide and tirzepatide, but not with semaglutide. Another fun fact is that both sema and tirzepatide gave me this annoying and nasty acid reflux but liraglutide that gave me all kind of sides somehow did not. Anyway, this is my personal experience and can differ from person to person. If one is asking me what the most applicable drug for the majority of people looking for weight loss is then it is for sure tirzepatide, as it does have a similiar appetite suppression but the overall tolerability profile is much better.
Another thing to consider is the price. It's really hard to beat semaglutide. Even dosing it at 2mg / week it is still cheaper than liraglutide or tirzepatide. And it will very likely give impressive results for the least costs.
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