MESO-Rx
Anabolic Steroids
Giant Semaglutide Thread (and other GLP-1 / GIP agonists)
- Thread starter Doodle
- Start date
Disarmer
Member
This was not my experience. I have heard some find the effect that quickly but I thought it was less common that my experience. Maybe I am wrong.
Disarmer
Member
Is your UGL dosing protocol the big post you wrote a couple weeks back. going from .25 up to 2.5 or so? That's what I've been following for QSC.
I'm at 1.5 now, the appetite suppression hit hard at 1.0.
Rido
Subscriber
Yea I did write it up.
That's nuts, some people are hyper responders compared to others
Disarmer
Member
I'm just happy it did eventually start working.
I'm a hyper responder at 1.5mg/week - sometimes just thinking about food makes me feel queasy but at least forcing in small portions comes with no ill effects.
Veritaz
New Member
I read through a lot in this thread and I couldn’t quite find the discussion on tolerance. So can anyone explain, maybe in their opinion, what’s the point of titrationing the dose all the way up to 2.5mg and staying there. In all the reading I’ve done it seems comparable to like a street drug that works great at first but then you have to keep upping the dose to chase the original high. It just doesn’t really make sense, so what happens at 2.5mg? Game over and start over once your tolerance resets?
Deadp007
Well-known Member
Increasing the dose to keep suppressing appetite with the goal of lowering body fat. You've noticed various AAS cycles for beginners, intermediates all the way to the pro's. They are not the same, higher doses, more compounds etc all for gaining muscle mass.
GLP-1's are for cutting body fat.
You will build up a tolerance, ppl deal with it various ways. Maybe think of it as a "cycle".
Can you recommend a second source if QSC is out of stock?
Rido
Subscriber
Yea. They have a thread here in the underground. You don't need to know much else
Iron_Yuppie
Well-known Member
CVS still can’t seem to fill my RX so I’ve been dipping in to my QSC stash. I am…underwhelmed by the effects.
HB_22
Well-known Member
The only side I get from GLP-1 RAs but also the worst of them all imho. It's fucking annoying.
Iron_Yuppie
Well-known Member
The clinical trials stopped at that dose. Can you, a non-participant in a current trial, use more than 2.4mg? Sure, you can do whatever you want. You can start wearing adult diapers and telling people you’re a long lost relative of Alexander the Great. But once you exceed the dose that was tested at the top end you’re outside the territory of what’s been studied. That doesn’t mean you’re at risk of some heretofore unknown side effect, it just means you’re going above what has been FDA approved. Considering this entire forum exists for people to discuss using drugs well beyond their original remit I wouldn’t be surprised if someone chose to up their dose of semaglutide to effectuate a change in their body composition just a tad more.
Rido
Subscriber
That sucks to hear. Gotta crank up the dose then lol.
Iron_Yuppie
Well-known Member
It’s true, but kind of not worth the cost. Once it hits that $60/w range it annoys me. It’s not like the cost is prohibitive, it’s just irritating, which I admit is not at all rational.
Rido
Subscriber
On a cut, everything is irritating
I still prefer tirzepatide over semaglutide for sure
Veritaz
New Member
What I’m getting at though is it seems people keep pushing the dose because it’s no longer effective as it once was. So where does it end? Do you keep upping the milligrams indefinitely?
Iron_Yuppie
Well-known Member
There is almost certainly a point of diminishing returns, but what that is I don’t think we can say, at least not this early in the game. Could you theoretically have to take 5mg/w to get the same effects you did at half that dose just two months prior? Sure. Or not. This is all going to depend on the individual and there isn’t a binary answer here.
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