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You do list some valid points for discussion but, these drugs do work and the loss is maintainable, but you have to put work into it. The people that rebound have not changed their diet at all, and just go back to old habits....
in five years, I don’t think you’ll hear anything more about these drugs. We Will all be onto the next weight loss drug.
...
Mounjaro may well end up being a $20B/yr drug within the next five years. It’s the definition of a blockbuster discovery and probably cumulatively puts up numbers that rival Humira when all is said and done.in five years, I don’t think you’ll hear anything more about these drugs.
No more than with any other calorie restrictive diet. I have yet to see any data showing malabsorption of nutrients because of these drugs.Is there any concern about malnutrition with these drugs ? Especially if you use them to get to a BMI under 18.5 ? I don't want to accidentally starve to death lol.
You are confusing two different things.Is there any concern about malnutrition with these drugs ? Especially if you use them to get to a BMI under 18.5 ? I don't want to accidentally starve to death lol.
I suspect that SalomeXtravaganza may have been exaggerating by using the actual term "malnutrition" as part of his question. I will say that I am on 1.5 mg/wk and had such little appetite over the weekend while traveling that I probably had an amount of food over 2 days that would equate to 1 regular meal. Was I at risk of dying from starvation? No. But I sure was lethargic and certainly was at risk of catabolizing muscleYou are confusing two different things.
Malnourishment is when someone lacks an essential nutrient -- this commonly amino acids, fatty acids, or vitamins that cannot be made by the body and must be consumed by food. A person can be both obese and malnourished by eating a ton of really poor quality food.
The research literature (as of this moment) on the GLP-1 agonists doesn't suggest they deplete a specific nutrient, nor do they prevent the absorption of any nutrient. In that sense, they are not an inherent cause of malnutrition.
So, under what circumstances can these compounds cause malnutrition? If your appetite is so suppressed that you cannot eat, or you experience persistent vomiting, you could certainly work your way into a malnourished state. Same if you take these, have a reduced dietary intake, and eat a really bad food selection.
There is a suggestion in the research that people who discontinue use of these compounds have a drastically reduced insulin response, at least for a time. I am taking that as a sign not to indulge in a lot of high glycemic index foods while taking these drugs, if only not to establish a shitty habit that might bite me in the ass when I'm done. I think that's good harm reduction advice in general -- don't use pharmaceutical enhancement as an excuse to abuse your body just because you might be able to get away with it temporarily.
OZEMPIC DOSING INSTRUCTIONS: Place 1ML in 2MG Vial or 2 ML in the 4mg vial | |||
Weekly Total Dose | Duration | Volume on Syringe | |
0.25mg | 4 weeks | 13 units | |
0.5mg | 4 weeks | 25 units | |
1mg | 4 weeks/ maintenance | 50 units | |
1.5mg | 4 weeks | 75 units | |
2mg | 4 weeks | 100 units | |
2.4mg | 4 weeks | 120 units/1.2ml |
Semaglutide: My preferred dosing is used with 1ML in a 2mg vial or 2 ml in 4mg Vial this is what I have used on other people | ||
Weekly Total Dose | Duration | Volume on Syringe |
0.4mg | 4 weeks | 20 units |
0.6mg | 4 weeks | 30 units |
1mg | 4 weeks/maintenance | 50 units |
1.5mg | 4 weeks | 76 units |
2mg | 4 weeks | 100 units |
2.4mg | 4 weeks | 120 units/1.2ml |
Tirzepatide. I would advise to stop when you hit 10mg a week and take a break for 3 months | ||
Weekly Total Dose | Duration | Volume on Syringe |
2.5mg | 4 weeks | 20 units |
5mg | 4 weeks*maintennace | 30 units |
7.5mg | 4 weeks | 50 units |
10mg | 4 weeks | 76 units |
12.5mg | 4 weeks | 100 units |
15mg | 4 weeks/ongoing | 120 units/1.2ml |
Okay but what is your height, and starting/current weights? It doesn't sound like they "stop" working, only that they have a maximum efficacy. It's not like you have unlimited weight to lose. Eventually you have to maintain. I am willing to take a drug like this to maintain my ideal weight.i took sema and mounj both on and off over the past year, mostly from QSC. For me I developed a significant tolerance at about 100 days in (but good weight loss). I ramped up sema to 3mg/week and tirz to 15/wk. My advice is: expect to have to continue to ramp dosage up with ever diminishing returns. For everyone that amount will be different.
Now, if you’re here looking for specific advice, please remember although this drug has been tested, It is only been tested up to the specified amounts and even then the studies only went out approximately a year. The semiglutide study showed a slight increase in weight after the 52 week mark suggesting the drug had worn off completely at 2.4/mg week. I’m actually surprised that in the mass media, there hasn’t been more reporting about the rebound effects, and especially the fact that the drug just simply doesn’t work very well anymore after someone being on it for several months.
in five years, I don’t think you’ll hear anything more about these drugs. We Will all be onto the next weight loss drug.
Remember, all these drugs will affect people in different ways. You really need to just do experimenting on yourself to see how your body reacts and how much you need.
Okay but if you had one meal every two days for the next six months surely you would become malnourished ?? So that is my concern.I suspect that SalomeXtravaganza may have been exaggerating by using the actual term "malnutrition" as part of his question. I will say that I am on 1.5 mg/wk and had such little appetite over the weekend while traveling that I probably had an amount of food over 2 days that would equate to 1 regular meal. Was I at risk of dying from starvation? No. But I sure was lethargic and certainly was at risk of catabolizing muscle
Who are the four? Have anyone use ultima?There is testing in the lab testing portion. I want to assume all UGL semaglutide is essentially from the same source.
Just pick where you get it from. I have pretty solid instructions at the top of this page.
With my dosing. 3 vials, 3 months.
I am on tirazepide (same drug class), clen, carnitine, hgh, metformin, lipo mic right now.
I have been a huge fan of the GLP drugs since the release.
There are 4 big name sources that sell it here and all of them have tested it. I think they have bac water for sale too
you can find them on here if you want to. its not hardWho are the four? Have anyone use ultima?
Yeah I did, my bad. Just being lazy was all. I am still looking for anyone’s opinions on Ultima Semaglutide thoughyou can find them on here if you want to. its not hard
I think its all the same shit. might need to start at a higher dose. no reason to screw people over on itYeah I did, my bad. Just being lazy was all. I am still looking for anyone’s opinions on Ultima Semaglutide though
Why are you on hgh semaglutide and insulin?Anyone who use Semaglutid, HGH and Insulin?
At the moment I'm using Semaglutid and HGH. Even without Semaglutid my blood sugar is good. At the moment I'm thinking about to add some insulin after the training.
Why? Because I train in the evening and it seems to be suboptimal because when the workout ends (11:30pm) the HGH still blocks the insulin mostly.
Until I'm going to sleep (2am) no hunger is upcoming. I force myself to eat to get my protein and carbohydrates. I do intermittent fasting so I only eat after the training.
That causes that I'm waking up at 4-5am and I could eat everything I can find.
thats not gonna suppress your hunger. might as well take metformin XR at nightAt the moment I use Semaglutid and HGH to cut. (No insulin at the moment)
The necessity of Insulin just come up into my mind because of the hunger flashes during the night