Hair Loss

[daledd]

Curious as to how nizoral/propecia will affect a cycle? I mean, will a cycle at say 500mg weekly overpower the medication and its use be pointless? Or can the medication help, but inhibit gains? Not sure how much these medications can lower ones free testosterone?
I'm trying to figure out the best medium to making the most gains on cycle, while losing the least amount of hair. Would injecting lower doses more frequently of say enanthate help at all even if the total amount of test taken per week was the same as someone dosing twice per week at higher miligrams?

I'm scheduling an appointment with my dermatologist and will be researching in the meantime..

From what I found on reddit, fin supposedly blocks 65% of the DHT conversion so basically the hairloss. So yes it'll decrease the hairloss, if you want to block it almost completely you need dutasteride.
Ill be getting some next week.

 

[Michael Scally MD]

Santos Z, Avci P, Hamblin MR. Drug discovery for alopecia: gone today, hair tomorrow. Expert Opin Drug Discov. 2015;1-24. http://informahealthcare.com/doi/abs/10.1517/17460441.2015.1009892

Introduction: Hair loss or alopecia affects the majority of the population at some time in their life, and increasingly, sufferers are demanding treatment. Three main types of alopecia (androgenic [AGA], areata [AA] and chemotherapy-induced [CIA]) are very different, and have their own laboratory models and separate drug-discovery efforts.

Areas covered: In this article, the authors review the biology of hair, hair follicle (HF) cycling, stem cells and signaling pathways. AGA, due to dihydrotesterone, is treated by 5-alpha reductase inhibitors, androgen receptor blockers and ATP-sensitive potassium channel-openers. AA, which involves attack by CD8+NK group 2D-positive (NKG2D+) T cells, is treated with immunosuppressives, biologics and JAK inhibitors. Meanwhile, CIA is treated by apoptosis inhibitors, cytokines and topical immunotherapy.

Expert opinion: The desire to treat alopecia with an easy topical preparation is expected to grow with time, particularly with an increasing aging population. The discovery of epidermal stem cells in the HF has given new life to the search for a cure for baldness. Drug discovery efforts are being increasingly centered on these stem cells, boosting the hair cycle and reversing miniaturization of HF. Better understanding of the molecular mechanisms underlying the immune attack in AA will yield new drugs. New discoveries in HF neogenesis and low-level light therapy will undoubtedly have a role to play.

 

[Voltrader]

Any idea where to get this stuff, Doc?

We have to take a visit to the Stanford research department everybody has a price don't they.

 

[Froz3nnn]

I did use finasteride, and i got commons sides as zero libido, i was strongless, etc..

obv if u use finasteride you won't use winstrol, masteron, tren (not for ain't dht derivated but for it's strong androgenic effect), and others..

i decided to wear a hair piece, (protesys), found a great top quality brand in my country and being top satisfied with my hair.. and, for the sake of discussion, i started aas only after i solved baldness problem with top quality hair piece..

I even tought to inject tren and winstrol directly in my head to speed baldness ahahahahahahahl.. no joke.. since if i got totally bald, the wear process would be easier..

Now i'm on masteron and winstrol, hope to lose some hair..

trust me i'm serious :}

and please don't use fina.. unless it is finaplix.. :}

 

[Froz3nnn]

I'm still laughing because the idea of using Winstrol Shampoo to got bald in some days..

 

[Froz3nnn]

I'll try to get raw DHT to make the Ultimate Baldness Shampoo..

Get bald or go home..

 

[Froz3nnn]

Get Bald or Die Tryin'

 

[56HUNTER]

Winstrol never caused real loss for me...and I have loss
Winstrol has poor binding to AR receptor thus not sure how it accelerates mpb

 

[Michael Scally MD]

Winstrol never caused real loss for me...and I have loss
Winstrol has poor binding to AR receptor thus not sure how it accelerates mpb

Where do you find the evidence?

 

[Michael Scally MD]

Fukuoka H, Suga H. Hair Regeneration Treatment Using Adipose-Derived Stem Cell Conditioned Medium: Follow-up With Trichograms. Eplasty. 2015;15:e10. http://www.eplasty.com/index.php?option=com_content&view=article&id=1344&catid=15&Itemid=116

Objective: Adipose-derived stem cells secrete various growth factors that promote hair growth. This study examined the effects of adipose-derived stem cell-conditioned medium on alopecia.

Methods: Adipose-derived stem cell-conditioned medium was intradermally injected in 22 patients (11 men and 11 women) with alopecia. Patients received treatment every 3 to 5 weeks for a total of 6 sessions. Hair numbers were counted using trichograms before and after treatment. A half-side comparison study was also performed in 10 patients (8 men and 2 women).

Results: Hair numbers were significantly increased after treatment in both male (including those without finasteride administration) and female patients. In the half-side comparison study, the increase in hair numbers was significantly higher on the treatment side than on the placebo side.

Conclusion: Treatment using adipose-derived stem cell-conditioned medium appears highly effective for alopecia and may represent a new therapy for hair regeneration.


A 49-year-old male patient. (A) Before treatment. (B) During treatment (4 months after initial treatment). (C) After treatment (10 months after initial treatment). (D) Final follow-up (2 years and 1 month after initial treatment).

 

[Michael Scally MD]

Panahi Y, Taghizadeh M, Marzony ET, Sahebkar A. Rosemary oil vs minoxidil 2% for the treatment of androgenetic alopecia: a randomized comparative trial. Skinmed. 2015;13(1):15-21. http://www.skinmedjournal.com/

Rosmarinus officinalis L. is a medicinal plant with diverse activities including enhancement microcapillary perfusion.

The present study aimed to investigate the clinical efficacy of rosemary oil in the treatment of androgenetic alopecia (AGA) and compare its effects with minoxidil 2%.

Patients with AGA were randomly assigned to rosemary oil (n = 50) or minoxidil 2% (n = 50) for a period of 6 months. After a baseline visit, patients returned to the clinic for efficacy and safety evaluations every 3 months. A standardized professional microphotographic assessment of each volunteer was taken at the initial interview and after 3 and 6 months of the trial.

No significant change was observed in the mean hair count at the 3-month endpoint, neither in the rosemary nor in the minoxidil group (P > .05). In contrast, both groups experienced a significant increase in hair count at the 6-month endpoint compared with the baseline and 3-month endpoint (P < .05). No significant difference was found between the study groups regarding hair count either at month 3 or month 6 (> .05).

The frequencies of dry hair, greasy hair, and dandruff were not found to be significantly different from baseline at either month 3 or month 6 trial in the groups (P > .05). The frequency of scalp itching at the 3- and 6-month trial points was significantly higher compared with baseline in both groups (P < .05). Scalp itching, however, was more frequent in the minoxidil group at both assessed endpoints (P < .05).

The findings of the present trial provided evidence with respect to the efficacy of rosemary oil in the treatment of AGA.

 

[Michael Scally MD]

Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations

Highlights
· Quorum sensing underlies collective regenerative behavior in a hair follicle population
· Sensing occurs via injury → CCL2 → macrophage → TNF-α → hair regeneration pathway
· Coupling molecular diffusion and cell mobility achieves a long signaling length scale
· Stem cell social behavior can be exploited to enhance the reliability of regeneration

Chen C-C, Wang L, Plikus MV, Jiang TX, Murray PJ, et al. Organ-Level Quorum Sensing Directs Regeneration in Hair Stem Cell Populations. Cell. 2015;161(2):277-90. https://www.sciencedirect.com/science/article/pii/S0092867415001828

Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury.

Plucking hair at different densities leads to a regeneration of up to five times more neighboring, unplucked resting hairs, indicating activation of a collective decision-making process.

Through data modeling, the range of the quorum signal was estimated to be on the order of 1 mm, greater than expected for a diffusible molecular cue.

Molecular and genetic analysis uncovered a two-step mechanism, where release of CCL2 from injured hairs leads to recruitment of TNF-α-secreting macrophages, which accumulate and signal to both plucked and unplucked follicles.

By coupling immune response with regeneration, this mechanism allows skin to respond predictively to distress, disregarding mild injury, while meeting stronger injury with full-scale cooperative activation of stem cells.


Maire To, Youk H. A Collective Path toward Regeneration. Cell. 2015;161(2):195-6. https://www.sciencedirect.com/science/article/pii/S0092867415003591

How do cells collectively control an organ’s behavior? By plucking various numbers of hairs from the mouse skin, Chen et al. show that hairs regenerate only when a sufficiently high density of them are plucked. Remarkably, a hair follicle can only regenerate in concert with other follicles, but not autonomously.

 

[uk-pharmaceuticals]

Hair loss can also be triggered by stress. Google telogen effluvium

 

[Michael Scally MD]

Yoshitake T, Takeda A, Ohki K, Inoue Y, Yamawaki T, et al. Five-year efficacy of finasteride in 801 Japanese men with androgenetic alopecia. J Dermatol. http://onlinelibrary.wiley.com/doi/10.1111/1346-8138.12890/abstract

Finasteride is standard medical treatment for androgenetic alopecia; however, no large studies with 5 years or more of follow up have been performed in Japan. The authors followed Japanese men with androgenetic alopecia treated with finasteride for 5 years to evaluate long-term treatment efficacy.

Of 903 men treated with finasteride (1 mg/day), 801 patients were evaluated over 5 years by modified global photographic assessment. Although the proportion of improvement was high (99.4%), modified global photographic assessment scores after 5 years of treatment were lower in patients with more advanced disease as measured by the modified Norwood-Hamilton scale.

After separating patients into "sufficient" and "insufficient" efficacy groups according to the modified global photographic assessment score after 5 years (scores >/=6 and <6, respectively), multivariate analysis showed that independent risk factors of insufficient efficacy were age at start of treatment of 40 years or more (P = 0.021) and classification on the modified Norwood-Hamilton scale (P < 0.001), whereas presence of stress at start of treatment was a negative predictor (P = 0.025).

In conclusion, continuous finasteride treatment for 5 years improved androgenetic alopecia with sustained effect among Japanese. Younger age and less advanced disease at start of treatment were the key predictors of higher finasteride efficacy.

 

[Michael Scally MD]

Sari I, Aykent K, Davutoglu V, Yuce M, Ozer O, et al. Association of male pattern baldness with angiographic coronary artery disease severity and collateral development. Neth Heart J. 2015;23(5):265-74. http://link.springer.com/article/10.1007/s12471-015-0688-3/fulltext.html

OBJECTIVE: We aimed to investigate whether there is an association between male pattern baldness and angiographic coronary artery disease (CAD) severity and collateral development, which has not been reported previously.

METHODS: Coronary arteriograms, CAD risk factors, lipid parameters and presence and severity of baldness in 511 male patients were prospectively evaluated. Baldness was classified into five groups. Severity of CAD was evaluated with the Gensini scoring system and collateral development with Rentrop scores.

RESULTS: Although subjects with a higher Gensini score had more frequent and severe baldness, they were older than the group with lower Gensini scores. Bald patients had a higher Gensini score when compared with their non-bald counterparts. In univariate analysis, age more than 60, body mass index more than 30, smoking and baldness were predictors of high Gensini scores. In multivariate analysis, only age more than 60, body mass index more than 30 and smoking were independent predictors of a high Gensini score. There were no differences in terms of presence and severity of baldness in subjects with and without adequate collateral development.

CONCLUSIONS: There was no relation between presence, severity and age of occurrence of male pattern baldness and Gensini and Rentrop scores, which are important measures of presence and severity of CAD.

 

[Michael Scally MD]

Watanabe Y, Nagashima T, Hanzawa N, Ishino A, Nakazawa Y, et al. Topical adenosine increases thick hair ratio in Japanese men with androgenetic alopecia. Int J Cosmet Sci. http://onlinelibrary.wiley.com/doi/10.1111/ics.12235/abstract

OBJECTIVE: Hair thickness is more important than hair density in the appearance of baldness in male with androgenetic alopecia (AGA). Adenosine improves hair loss by stimulating hair growth and by thickening hair shafts in women. The objective of this study was to evaluate the hair growth efficacy and safety of topical adenosine in men with AGA.

METHODS: A lotion containing either adenosine or niacinamide was administered to the scalps of 102 Japanese men twice daily for 6 months in a double-blind, randomized study. Efficacy was evaluated by dermatologists who assessed the quality of the hair, and by calculating the percentages of vellus-like and thick hairs among the vertex hairs, as well as hair density.

RESULTS: Adenosine was significantly (p < 0.05) superior to niacinamide in terms of global improvement of AGA, increase in the percentage of thick hairs (at least 60 mum), and self-assessment of hair thickness by the study participants. No causal adverse event due to the adenosine lotion was observed.

CONCLUSION: These data indicate that adenosine increases thick hair ratio in Japanese men with AGA, and this compound is useful for the improvement of AGA.

 

[Michael Scally MD]

Aljuffali IA, Pan TL, Sung CT, Chang SH, Fang JY. Anti-PDGF receptor beta antibody-conjugated squarticles loaded with minoxidil for alopecia treatment by targeting hair follicles and dermal papilla cells. Nanomedicine. http://www.nanomedjournal.com/article/S1549-9634(15)00098-2/abstract

This study developed lipid nanocarriers, called squarticles, conjugated with anti-platelet-derived growth factor (PDGF)-receptor beta antibody to determine whether targeted Minoxidil (MXD) delivery to the follicles and dermal papilla cells (DPCs) could be achieved.

Squalene and hexadecyl palmitate (HP) were used as the matrix of the squarticles. The PDGF-squarticles showed a mean diameter and zeta potential of 195 nm and -46 mV, respectively. Nanoparticle encapsulation enhanced MXD porcine skin deposition from 0.11 to 0.23 mug/mg. The antibody-conjugated nanoparticles ameliorated follicular uptake of MXD by 3-fold compared to that of the control solution in the in vivo mouse model.

Both vertical and horizontal skin sections exhibited a wide distribution of nanoparticles in the follicles, epidermis, and deeper skin strata. The encapsulated MXD moderately elicited proliferation of DPCs and vascular endothelial growth factor (VEGF) expression.

The active targeting of PDGF-squarticles may be advantageous to improving the limited success of alopecia therapy.

 

[Michael Scally MD]

Ors S, Ozkose M, Ors S. Follicular Unit Extraction Hair Transplantation with Micromotor: Eight Years Experience. Aesthetic Plast Surg. http://link.springer.com/article/10.1007/s00266-015-0494-8

OBJECTIVE: Follicular unit extraction (FUE) has been performed for over a decade. Our experience in the patients who underwent hair transplantation using only the FUE method was included in this study.

METHODS: A total of 1000 patients had hair transplantation using the FUE method between 2005 and 2014 in our clinic.

RESULTS: Manual punch was used in 32 and micromotor was used in 968 patients for graft harvesting. During the time that manual punch was used for graft harvesting, 1000-2000 grafts were transplanted in one session in 6-8 h. Following micromotor use, the average graft count was increased to 2500 and the operation time remained unchanged. Graft take was difficult in 11.1 %, easy in 52.2 %, and very easy in 36.7 % of our patients.

CONCLUSIONS: The main purpose of hair transplantation is to restore the hair loss. During the process, obtaining a natural appearance and adequate hair intensity is important. In the FUE method, grafts can be taken without changing their natural structure, there is no need for magnification, and the grafts can be transplanted directly without using any other processes. Because there is no suture in the FUE method, patients do not experience these incision site problems and scar formation. The FUE method enables us to achieve a natural appearance with less morbidity.

 

[Victor]

Does nizoral shampoo hinder gains in any way? It blocks dht at the scalp right? Decreasing the chance of losing hair.

 

[hardbodygirl]

I find this article intriguing. I have a few things i'd like to contribute here. I have heard that hair loss in men is aquired from their mothers side of the family... not sure about women though. My brother is living proof of that, since he has shot enough shit to float a boat around and he has no hair loss whatsoever. He has used his share of DHT based compounds. All the men in my mothers side of the family all had a full head of hair until they died in their 80's. Therefore it is my belief... if you lose
your hair, your already predisposed to this genetically, and there's not a fucken thing you can do about it, and using steroids is probably just going to speed it up! If you lose your hair guys... shave your head! And then hold your bald head high! I personally, have used my share of Winstrol.. and i still have a full, thick ass head of hair.
So you draw the conclusion here yourselves... me and my brother have both used AAS heavily for between 25 and 30 years, and we both still enjoy normal to thick hair growth, with no areas thinning, or "scalpy" either. Hair on the top of the scalp is different than that of the side of the head over the ears. When transplanting
hair, they take hair from the sides of the scalp, and transplant it to the top where there is balding. This apparently solves the problem in some cases, and this hair continues to grow healthy. Obviously i'm not making any claims here, that what i've suggested is an absolute fact... i'm more or less just stating what i have heard, and also my opinion regarding bald men... i think bald men are SEXY! So my 2 cents for what its worth here fellas... don't sweat losing your hair! Skin that smokehouse! Most of you shave the rest of your body anyway... so why should your head be any different? Lol!