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Anabolic Steroids

Hair Loss

Torkamani N, Rufaut NW, Jones L, Sinclair RD. Beyond goosebumps: does the arrector pili muscle have a role in hair loss? Int J Trichology 2014;6(3):88-94. http://www.ijtrichology.com/article...=6;issue=3;spage=88;epage=94;aulast=Torkamani

The arrector pili muscle (APM) consists of a small band of smooth muscle that connects the hair follicle to the connective tissue of the basement membrane. The APM mediates thermoregulation by contracting to increase air-trapping, but was thought to be vestigial in humans. The APM attaches proximally to the hair follicle at the bulge, a known stem cell niche. Recent studies have been directed toward this muscle's possible role in maintaining the follicular integrity and stability. This review summarizes APM anatomy and physiology and then discusses the relationship between the follicular unit and the APM. The potential role of the APM in hair loss disorders is also described, and a model explaining APM changes in hair loss is proposed.
 
Urysiak-Czubatka I, Kmiec ML, Broniarczyk-Dyla G. Assessment of the usefulness of dihydrotestosterone in the diagnostics of patients with androgenetic alopecia. Postepy Dermatol Alergol 2014;31(4):207-15. http://www.termedia.pl/Original-pap...s-with-androgenetic-alopecia,7,22331,1,1.html

INTRODUCTION: Androgenetic alopecia (AGA) is the most common form of hair loss. Clinically observed hair loss is due to the continuous miniaturization of affected hair follicles. Genetic factors and androgenic factors especially dihydrotestosterone (DHT), which is a testosterone tissue metabolite, play major roles in the pathogenesis of AGA. However, expert opinions about the usefulness of DHT in the diagnosis of this type of alopecia are divided.

AIM: To evaluate the usefulness of DHT level in patients with androgenetic alopecia compared with the control group.

MATERIAL AND METHODS: The study comprised 49 subjects: 19 women and 9 men with androgenetic alopecia. The control group consisted of 17 healthy women and 4 men without hair loss.

RESULTS: Increased serum concentrations of DHT were observed in patients with androgenetic alopecia (17 women, 5 men), but also in the control group. The differences in mean values of DHT were not significant according to the types of alopecia and the control group. Increased serum concentrations of DHT were not correlated with the advance of alopecia.

CONCLUSIONS: Dihydrotestosterone is the most influential androgen and seems to play a very important role in the pathogenesis of androgenetic alopecia. Based on the results of our study and others, the most important factors would appear to be the genetically-determined sensitivity of the follicles to DHT and their different reactions to androgen concentration.
 
Ustuner ET. Cause of androgenic alopecia: crux of the matter. Plast Reconstr Surg Glob Open 2013;1(7):e64. http://journals.lww.com/prsgo/Fullt...drogenic_Alopecia___Crux_of_the_Matter.9.aspx

SUMMARY: What is wrong with the current understanding of etiopatho genesis of androgenic alopecia (AGA)? What is the most important question to ask to understand AGA? Why is that question skimped? Which findings are interpreted incorrectly? Is there anything that has not been discerned about AGA until today? What are the deceptive factors for investigators? Is it possible to snap the whole view uninterruptedly in one clear picture? Answers and an overview with fresh perspectives are provided.
 
Michael Scally MD said:
Ustuner ET. Cause of androgenic alopecia: crux of the matter. Plast Reconstr Surg Glob Open 2013;1(7):e64. http://journals.lww.com/prsgo/Fullt...drogenic_Alopecia___Crux_of_the_Matter.9.aspx

SUMMARY: What is wrong with the current understanding of etiopatho genesis of androgenic alopecia (AGA)? What is the most important question to ask to understand AGA? Why is that question skimped? Which findings are interpreted incorrectly? Is there anything that has not been discerned about AGA until today? What are the deceptive factors for investigators? Is it possible to snap the whole view uninterruptedly in one clear picture? Answers and an overview with fresh perspectives are provided.
Click to expand...
It's crazy we can go all over the place in Space (the moon, Mars?), but this cannot be solved. The human body (I guess all creatures) is still somewhat of a mystery, huh Dr. Scally?
 
heady muscle said:
Interesting find. Good post. I guess you can't use before bedtime though!:D
Click to expand...

When I used it, it didn't give me any stim effects but I did notice much thicker hair and the front corners of your head that usually goes bald (like the front corners...idk the name for it lol) started growing and I basically had a straight line hair. But when I stopped they fell back off slowly.
 
Highlights
· Alopecia has been associated with an increased risk of coronary heart disease.
· 31 studies comprising 29,254 participants with alopecia were eligible for the meta-analysis.
· Alopecia is associated with an increased risk of coronary heart disease, hyperinsulinaemia, insulin resistance, and metabolic syndrome.
· Alopecia was linked to higher serum cholesterol levels, higher serum triglyceride levels, higher systolic/diastolic blood pressures.
· Alopecia is associated with an increased risk of coronary heart disease and cardiovascular risk factors.

Trieu N, Eslick GD. Alopecia and its association with coronary heart disease and cardiovascular risk factors: A meta-analysis. International Journal of Cardiology 2014;176(3):687-95. http://www.internationaljournalofcardiology.com/article/S0167-5273(14)01289-3/abstract

Background - Alopecia has been associated with an increased risk of coronary heart disease as well as the following risk factors for cardiovascular disease: hyperinsulinaemia, insulin resistance, metabolic syndrome, dyslipidaemia, and hypertension. We performed a meta-analysis to quantitatively determine the level of risk of coronary heart disease and risk factors in individuals with alopecia.

Methods - A systematic literature search was conducted using several databases. We calculated pooled odds ratios and 95% confidence intervals using a random effects model.

Results - In total, 31 studies comprising 29,254 participants with alopecia were eligible for the meta-analysis and showed that alopecia is associated with an increased risk of coronary heart disease (OR 1.22, 95% CI: 1.07–1.39), hyperinsulinaemia (OR 1.97, 95% CI: 1.20–3.21), insulin resistance (OR 4.88, 95% CI: 2.05–11.64), and metabolic syndrome (OR 4.49, 95% CI: 2.36–8.53). Individuals with alopecia were also shown to be more likely compared to those without alopecia to have higher serum cholesterol levels (OR 1.60, 95% CI: 1.17–2.21), higher serum triglyceride levels (OR 2.07, 95% CI: 1.32–3.25), higher systolic blood pressures (OR 1.73, 95% CI: 1.29–2.33), and higher diastolic blood pressures (OR 1.59, 95% CI: 1.16–2.18).

Conclusions - Alopecia is associated with an increased risk of coronary heart disease, and there appears to be a dose–response relationship with degree of baldness whereby the greater the severity of alopecia, the greater the risk of coronary heart disease. Alopecia is also associated with an increased risk of hypertension, hyperinsulinaemia, insulin resistance, metabolic syndrome, and having elevated serum total cholesterol and triglyceride levels.
 
intel said:
When I used it, it didn't give me any stim effects but I did notice much thicker hair and the front corners of your head that usually goes bald (like the front corners...idk the name for it lol) started growing and I basically had a straight line hair. But when I stopped they fell back off slowly.
Click to expand...
seems like most things when you stop using them your hair regresses. I may try it. Good post.
 
Started to lose my hair at 17. Shaved it off and never looked back. Now that I'm 37 and on my first cycle. I think my hair is growing faster where it still grows.
 
fokai500 said:
Started to lose my hair at 17. Shaved it off and never looked back. Now that I'm 37 and on my first cycle. I think my hair is growing faster where it still grows.
Click to expand...

It's not just you fokai, it seems like when I am "on" that I have to shave EVERYWHERE much more frequently. It almost gets out of control how much more quickly my facial and body hair seems to grow.
 
fokai500 said:
Yeah I shouldn't of started aas 20 years ago. I could of got laid a lot more.
Click to expand...

Meh, getting laid is overrated.

Okay, that was the stupidest thing I have ever posted here on Meso.

I have to say that I have gotten laid significantly more BECAUSE of steroids, not in spite of them. I have had girls tell me that they wanted to hook up with me just to see what it was like to get handled by a guy with muscles. I must say that I always considered that a fair deal for both parties. :cool:

Plus, let's be honest, the confidence that many juicers have when approaching (and banging) chicks comes with using AAS.
 
Qi J, Garza LA. An overview of alopecias. Cold Spring Harb Perspect Med 2014;4(3). http://perspectivesinmedicine.cshlp.org/content/4/3/a013615.long

Hair loss is a topic of enormous public interest and understanding the pathophysiology and treatment of various alopecias will likely make a large impact on patients' lives. The investigation of alopecias also provides important insight in the basic sciences; for instance, the abundance of stem cell populations and regenerative cycles that characterize a hair follicle render it an excellent model for the study of stem cell biology. This review seeks to provide a concise summary of the major alopecias with regard to presentation and management, and correlate these to recent advances in relevant research on pathogenesis.
 
Mirmirani P. Age-related hair changes in men: Mechanisms and management of alopecia and graying. Maturitas. http://www.sciencedirect.com/science/article/pii/S0378512214003259

The appearance of human scalp hair is often tied to perceptions of youth and virility, especially in men. Hair loss, or alopecia and hair graying are commonly associated with advancing age and are frequently a source for emotional distress and anxiety.

Our understanding of the complex molecular signals and mechanisms that regulate and influence the hair follicle has expanded in recent years. By harnessing this understanding we are poised to address the esthetic concerns of aging hair.

Additionally, changes in the hair follicle may be a reflection of systemic senescent signals, thus because of its accessibility, the hair follicle may serve as an important research tool in gerontology.

In this review, the most current knowledge and research regarding mechanisms of androgenetic alopecia, senescent alopecia, and graying are discussed, as are extrinsic factors that may contribute to hair changes with age. Evidence based management strategies for treatment of age-related hair changes are also reviewed.
 

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