Hgh length?

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What is the reason behind NOT using rHGH and T3 ( for those who are hypothyroidal, e.g. 100/25 T4/T3) that you stated?
I guess not to shutdown your thyroid and fuck T4 production, but for those of us who already take T4 and T3 is there any problem regarding rHGH not doing its job properly or not letting it pheripherically convert T4 to T3 due to the supplementation of T3?
Or was more like what you said about the T4 supplementation and higher converstion to T3 ending in thyrotoxicosis?
The problem with taking exogenous T3 and rhGH is at least additive protein breakdown and dysregulation of the HPT axis (hypothalamo-thyro). If talking exogenous T4+T3, then you're increasing the risk for overt thyrotoxicosis.

T3 causes net protein breakdown (yes it increases protein turnover, resulting in more protein loss). Further, it preferentially catabolizes hypertrophied muscle (reflected by reduction to type IIA fiber cross-sectional area).

Did you ever read the thyroid hormone effects on protein turnover (Peter Bond Article)?. Most noteworthy, 75 µg of exogenous T3 increases RMR by 15% and 100 µg exogenous T3 for 2 weeks reduced type IIA fiber CSA (this reflects hypertrophied muscle) in line with this increased RMR (though there may be some compensatory mechanism that antagonizes the protein catabolic effects over longer periods, staving off further muscle loss).
 
Last quote from:

What is the reason behind NOT using rHGH and T3 ( for those who are hypothyroidal, e.g. 100/25 T4/T3) that you stated?
I guess not to shutdown your thyroid and fuck T4 production, but for those of us who already take T4 and T3 is there any problem regarding rHGH not doing its job properly or not letting it pheripherically convert T4 to T3 due to the supplementation of T3?
Or was more like what you said about the T4 supplementation and higher converstion to T3 ending in thyrotoxicosis?
Addressing hypothyroid users of rhGH is challenging. Growth response can be affected depending upon the underlying cause of the pathology. Anyhow, if already Rx'd a med. you don't want to ever discontinue that without discussion with your MD.
 
The funny thing is your total T3 has not truly increased, just the free T3 (probably low TBG due to blasting the months before).

So how long were you on 150mcg of T4 before yesterday's bloodwork? Since I see you took 100mcg some months before.
Anyways you thyroid is completely shut down, I would try to lower your exogenous T4 intake back to 100mcg(was already on a safe spot around 1, just below) or 112mcg, 125mcg as maximum.
 
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Addressing hypothyroid users of rhGH is challenging. Growth response can be affected depending upon the underlying cause of the pathology. Anyhow, if already Rx'd a med. you don't want to ever discontinue that without discussion with your MD.

I know, I just introduced 25mcg exogenous T3 because I was always on the low side range [0.8-2.2] total T3, between 0.8-0.9 when on maintenance/surplus, 0.5-0.6 when dieting, due to the poor conversion of those only treated with T4. I was treated only with 100mcg for several years.

I will have to retest in some weeks and see where I am now with the increased conversion of the T4 to T3, in the worst case I will just decrease to 12.5mcg T3 or simply stopping it if rHGH has increased my total T3 due to the better pheripherical conversion.


Did you ever read the thyroid hormone effects on protein turnover (Peter Bond Article)?. Most noteworthy, 75 µg of exogenous T3 increases RMR by 15% and 100 µg exogenous T3 for 2 weeks reduced type IIA fiber CSA (this reflects hypertrophied muscle) in line with this increased RMR (though there may be some compensatory mechanism that antagonizes the protein catabolic effects over longer periods, staving off further muscle loss).
I remember taking a look at it some months ago, I will read it again paying even more attention.
Anyways when I talk about taking exogenous T3 I am talking about having it in the optimal range, not to overdose it like in harsh preps.
I do not think that, someone coming from a poor conversion like the one I had when treated only with T4, 25mcg T3 plus the rHGH conversion puts me at the same level of someone who is taking 75-100 mcg of exogenous T3.

As I said, I will do different bloodwoorks these months/weeks to reevaluate my thyroid and adjust my thyroid dosage once again.
 
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The funny thing is your total T3 has not truly increased, just the free T3 (probably low TBG due to blasting the months before).

So how long were you on 150mcg of T4 before yesterday's bloodwork? Since I see you took 100mcg some months before.
Anyways you thyroid is completely shut down, I would try to lower your exogenous T4 intake back to 100mcg(was already on a safe spot around 1, just below) or 112mcg, 125mcg as maximum.
I'm assuming about a month and a half. I am gonna restart it at 100. I skipped yesterday and today. The T4 has a half life of 6-7 days.


its actually 0.19 not 0.019.


I was gonna take it every 2-3 days and then eventually once a week to allow it to increase slowly
 
I'm assuming about a month and a half. I am gonna restart it at 100. I skipped yesterday and today. The T4 has a half life of 6-7 days.


its actually 0.19 not 0.019.


I was gonna take it every 2-3 days and then eventually once a week to allow it to increase slowly
Oh, that is fine, not that bad then lol. 0.019 was truly suppresed.
I tried 112mcg after starting TRT, it made my TSH 0.100, went back to 100 mcg put my TSH around 1-1,5
 
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Last quote from:

What is the reason behind NOT using rHGH and T3 ( for those who are hypothyroidal, e.g. 100/25 T4/T3) that you stated?
I guess not to shutdown your thyroid and fuck T4 production, but for those of us who already take T4 and T3 is there any problem regarding rHGH not doing its job properly or not letting it pheripherically convert T4 to T3 due to the supplementation of T3?
Or was more like what you said about the T4 supplementation and higher converstion to T3 ending in thyrotoxicosis?
you supplement T4 not T4 on HGH. and it might not even be mandatory according to typeII who's opinion I respect highly. Anthony Roberts I also respect highly, and I'm gonna stay o the safe side and supplement T4 because there is no harm.
 
you supplement T4 not T4 on HGH. and it might not even be mandatory according to typeII who's opinion I respect highly. Anthony Roberts I also respect highly, and I'm gonna stay o the safe side and supplement T4 because there is no harm.
I suffer hypothyroidism, started as subclinical hypo, T4 is the basic med they give to treat it. Nothing to do with rHGH use. It puts me on optimal TSH and T4(both total and free) but the conversion to T3 is always poorer compared to euthyroidal persons.
 
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I'm sure my body is adjusting to not being on t4 but since stopping the lethargy is real. Been tired for the past 3 fucking days. Really bad. Follow up blood work is Monday
 
Why? If you were convinced to continue it. Were you afraid of something?
I did it to see if it would even be necessary. Some of these are not evidence based practice.


If your body would naturally adjust to it then it wouldn't be necessary.

I'll see how it is.
 
I did it to see if it would even be necessary. Some of these are not evidence based practice.


If your body would naturally adjust to it then it wouldn't be necessary.

I'll see how it is.
Feel free to quote me when you have a new thyroid bloodwork to take a look!
 
@Cridi887 do note a direct effect of GH is on the adrenocortical system, conversion of cortisol to inactive cortisone. Lethargy can be the result. Anecdotally, this may be more dramatic with products that contain a high dimer content.
 
@Cridi887 do note a direct effect of GH is on the adrenocortical system, conversion of cortisol to inactive cortisone. Lethargy can be the result. Anecdotally, this may be more dramatic with products that contain a high dimer content.
I haven't changed the brands yet and have been running it from the same batch.


I am now experiencing some Brian fog and lethargy. It has been going on over the past few days which fo kind of like up with stopping t4 2 weeks ago. I have considered dropping the hgh dose by 25% but am still on the fence.

I am just assuming it may be something I need to put up with for a little.
 
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