How does this LIGHT DNP cycle look?

[kilsong]

This is my first DNP cycle. Have 50 mg DNP caps on hand.
Currently on Tren Ace 75mg EOD and Test 150mg per week.

Age:46
Height: 6'4
Weight: 255 lbs
Unknown bodyfat %--but below 15% but I'm in shape with medium visual abs.
Extremely vascular.

I know everybody says to start at 200mg per day to assess tolerance, but I'm starting at 100mg.

Day 1-100mg
Day 2-100mg
Day 3-100mg

IF its I haven't had an allergic reaction, day 4 forward looks as follows:

Day 4-200mg
Day 5-200mg
Day 6-200mg

IF all is bearable, day 7 forward will look as follows:

Day 7-300mg
Day 8-300mg
Day 9-300mg
Day 10-300mg

Perhaps-300 or even 400 mg for an additional 3-5 days.

I'll be applying standard precautions with supplements and high water intake.

Suggestions? Comments? Concerns?

 

[Docd187123]

You are so fukin moronic. Is that why their looking for a modified, safer, newer version? Again you made my fukin point jack off. DNP out their is pure toxic shit and that's a fact.

You do realize that the safer, modified version is simply a time released version of the original DNP right??? Nothing really changes about it besides the rate at which it acts.

 

[hurricane]

You do realize that the safer, modified version is simply a time released version of the original DNP right??? Nothing really changes about it besides the rate at which it acts.

The DNP has also been biochemically altered to be less toxic. Also its a much lower dose. But yes the basics of DNP are there. But, pharmacological DNP being offered in a "safer" version by say Pfizer, is not what's out there. Correct? And until it is I think the way its used now is insanity. Were not going to agree. I don't see DNP as anything but trouble. I respect that you think differently, but agree to disagree.

 

[Docd187123]

The DNP has also been biochemically altered to be less toxic. Also its a much lower dose. But yes the basics of DNP are there. But, pharmacological DNP being offered in a "safer" version by say Pfizer, is not what's out there. Correct? And until it is I think the way its used now is insanity. Were not going to agree. I don't see DNP as anything but trouble. I respect that you think differently, but agree to disagree.

It's only less toxic bc it's a slower release which means serum levels don't build up as high. It's other properties remain unchanged.

No, you're right it's not being offered by any pharmaceutical company right now but do you understand how long it takes to get a product approved to market by the FDA? Plus the Yale researchers have only just found out about this in late 2014 or early 2015.

You're welcome to an opinion and we can agree to disagree but the facts speak pretty clearly for themselves.

 

[hurricane]

It's only less toxic bc it's a slower release which means serum levels don't build up as high. It's other properties remain unchanged.

No, you're right it's not being offered by any pharmaceutical company right now but do you understand how long it takes to get a product approved to market by the FDA? Plus the Yale researchers have only just found out about this in late 2014 or early 2015.

You're welcome to an opinion and we can agree to disagree but the facts speak pretty clearly for themselves.

Agree with everything except that the DNP has been altered to be a safer version. Yes its time release, stable levels, and all that, but the drug has been tweaked chemically.

 

[hurricane]

It's only less toxic bc it's a slower release which means serum levels don't build up as high. It's other properties remain unchanged.

No, you're right it's not being offered by any pharmaceutical company right now but do you understand how long it takes to get a product approved to market by the FDA? Plus the Yale researchers have only just found out about this in late 2014 or early 2015.

You're welcome to an opinion and we can agree to disagree but the facts speak pretty clearly for themselves.

I'll tell you this. You get this passed by the FDA and are assured its safe. I'll take the hour drive to Yale and kiss those Yale researchers asses. We could radically reduce obesity and other diseases weight related. You get that done and I'll shout DNP from the rooftop.

 

[MrRippedZilla]

It's only less toxic bc it's a slower release which means serum levels don't build up as high. It's other properties remain unchanged.

No, you're right it's not being offered by any pharmaceutical company right now but do you understand how long it takes to get a product approved to market by the FDA? Plus the Yale researchers have only just found out about this in late 2014 or early 2015.

You're welcome to an opinion and we can agree to disagree but the facts speak pretty clearly for themselves.

The key point.

Anyone waiting for FDA approval to determine the safety profile of a drug....on steroid board...I can't even...no.

The authors of that rat study made it pretty clear in the supplemental material that the only thing they changed was the rate of release with the assumption that this will reduce toxicity based on an acute experiment. My hunch is that this apparent "lack of toxicity" won't play out since it is a pretty important part of what makes DNP an awesome thermogenic.

DNP is toxic because it basically acts like a metabolic poison.
Oxidative phosphorylation uncoupling to prevent oxi metabolism = reduced efficiency of ADP>ATP conversion resulting in heat & cell mitochon working harder (increased glucose uptake) = metabolism increase & ATP production via glycolysis.
The "reduced efficiency" part is irreversible and is also where the toxicity comes into play (dose dependent of course). Take this away and you end up with a safer but much less effective drug (the researchers are well aware of this) so instead its more a case of playing around with the boundaries (release rate, etc) rather than messing with the foundation itself.
Basically, its still going to be a metabolic poison but with different ranges re therapeutic/toxic dosing.

I felt like expanding on your post because I like you Doc

 

[hurricane]

The key point.

Anyone waiting for FDA approval to determine the safety profile of a drug....on steroid board...I can't even...no.

The authors of that rat study made it pretty clear in the supplemental material that the only thing they changed was the rate of release with the assumption that this will reduce toxicity based on an acute experiment. My hunch is that this apparent "lack of toxicity" won't play out since it is a pretty important part of what makes DNP an awesome thermogenic.

DNP is toxic because it basically acts like a metabolic poison.
Oxidative phosphorylation uncoupling to prevent oxi metabolism = reduced efficiency of ADP>ATP conversion resulting in heat & cell mitochon working harder (increased glucose uptake) = metabolism increase & ATP production via glycolysis.
The "reduced efficiency" part is irreversible and is also where the toxicity comes into play (dose dependent of course). Take this away and you end up with a safer but much less effective drug (the researchers are well aware of this) so instead its more a case of playing around with the boundaries (release rate, etc) rather than messing with the foundation itself.
Basically, its still going to be a metabolic poison but with different ranges re therapeutic/toxic dosing.

I felt like expanding on your post because I like you Doc

Based on 6 weeks at a slower absorbing rate how long would one potentially be able to stay on? I would think that prolonged exposure would still cause negative effects. As you said, where is a sweet spot for being safe and still effective, but not to the point of causing possible dangerous body temperatures. Honestly I think drug companies would rather keep the population fat anyways.

 

[LonelyDrug]

i want to take dnp too but i wonder how i have to eat while on it

 

[Rook2135]

WARNING Long ass post not for the faint of heart.

i want to take dnp too but i wonder how i have to eat while on it

It depends what your goals, size, and dicipline. Theres several diets that work, but for the sake of simplicity I will narrow it down. Some people choose a keto diet for max fat loss and to keep the heat relatively lower. Other people keep carbs normal because they beleive that will lessen the carb cravings once your done with DNP. I dont like to fuck around much so I do keto, just my preference no journal cite there.

As for the Calories once again it depends on your dicipline and goals for the cycle.

To keep it very simple (for da dummies), most people ive heard of use maintnence calories (their reasoning not mine) so that the carb craving dont get you in the end. Other people seem to do lower Calories ie 1500-1800 for max fat loss.

Even though DNP is not catabolic, at very low cal intake one would think there is muscle lost. Some people suggest that when you get that sulfuric smell to your breath that your body is using mucle proteins for energy. So dont go below 1500 cal. This also depends on the size of the person . A 275 lb dude at 15 pecent bodyfat would need alot more cal.

Again all of this is my opinion so take it for a grain of salt, im certainly not an expert. If anyone wants to correct any of this please feel free, as I dont want to give missinformation.


If you want to be more specific which I highly suggest, then you need to know that every 100 mg of DNP raises your metabolism by about 11 percent.

More on this a quote from a member.

DNP boost in relation to dose?

"According to the original clinical research (Cutting and Tainter's work), every 100mg of crystal DNP per day will increase metabolic rate an averageof 11%. Note that this is only an average. Individual sensitivity to it will vary greatly. Also, this assumes crystal DNP content (powder DNP, which is stronger, is about 15% per 100mg). Finally, this already takes into account the long half-life and indicates theincrease in metabolic rate after the drug accumulates (so after 3-5 days at a given dose).

So, for example, a daily dose 400mg of powder DNP (after it accumulates) will increase metabolic rate an average of 60%. 400mg/day of crystal DNP will increase metabolic rate an average of44%."

Not 100 percent on his math but you get the general gist. Roughly 100 mg of DNP increases metabolism by 11-15 percent, assuming no plateau and linear correlation.

So if Person A who needs 2500 calories for maintnance (excluding workout) was to take DNP at 100 mg. That would constitude an 11 percent (roughly) increase in metabolism. Thats an extra 275 which would put you at a net of 2225 calories.

Also note that DNP accumulates in your body to the point that a daily 125 mg dose will turn into 203 , 253 , 284 on day 1, 2, 3, and 4 at a metabolic increase of 13.75%, 22.33%, 27.83%, 31.24% in that order.

 

[LonelyDrug]

WARNING Long ass post not for the faint of heart.



It depends what your goals, size, and dicipline. Theres several diets that work, but for the sake of simplicity I will narrow it down. Some people choose a keto diet for max fat loss and to keep the heat relatively lower. Other people keep carbs normal because they beleive that will lessen the carb cravings once your done with DNP. I dont like to fuck around much so I do keto, just my preference no journal cite there.

As for the Calories once again it depends on your dicipline and goals for the cycle.

To keep it very simple (for da dummies), most people ive heard of use maintnence calories (their reasoning not mine) so that the carb craving dont get you in the end. Other people seem to do lower Calories ie 1500-1800 for max fat loss.

Even though DNP is not catabolic, at very low cal intake one would think there is muscle lost. Some people suggest that when you get that sulfuric smell to your breath that your body is using mucle proteins for energy. So dont go below 1500 cal. This also depends on the size of the person . A 275 lb dude at 15 pecent bodyfat would need alot more cal.

Again all of this is my opinion so take it for a grain of salt, im certainly not an expert. If anyone wants to correct any of this please feel free, as I dont want to give missinformation.


If you want to be more specific which I highly suggest, then you need to know that every 100 mg of DNP raises your metabolism by about 11 percent.

More on this a quote from a member.

DNP boost in relation to dose?

"According to the original clinical research (Cutting and Tainter's work), every 100mg of crystal DNP per day will increase metabolic rate an averageof 11%. Note that this is only an average. Individual sensitivity to it will vary greatly. Also, this assumes crystal DNP content (powder DNP, which is stronger, is about 15% per 100mg). Finally, this already takes into account the long half-life and indicates theincrease in metabolic rate after the drug accumulates (so after 3-5 days at a given dose).

So, for example, a daily dose 400mg of powder DNP (after it accumulates) will increase metabolic rate an average of 60%. 400mg/day of crystal DNP will increase metabolic rate an average of44%."

Not 100 percent on his math but you get the general gist. Roughly 100 mg of DNP increases metabolism by 11-15 percent, assuming no plateau and linear correlation.

So if Person A who needs 2500 calories for maintnance (excluding workout) was to take DNP at 100 mg. That would constitude an 11 percent (roughly) increase in metabolism. Thats an extra 275 which would put you at a net of 2225 calories.

Also note that DNP accumulates in your body to the point that a daily 125 mg dose will turn into 203 , 253 , 284 on day 1, 2, 3, and 4 at a metabolic increase of 13.75%, 22.33%, 27.83%, 31.24% in that order.

excatly what i need thanks man

also do you run t3 with your dnp ?

 

[Rook2135]

excatly what i need thanks man

also do you run t3 with your dnp ?

DNP is known to lower your t3, t4 production expecially on long cycle or high doses. On a short run many people choose not to add t3. After DNP your body goes back to its normal thyroid function within a week. If your doing higher doses, or are worried about a carb rebound I would suggest t3 towards the end of the cycle amongst other drugs. Some people run t3 troughout the cycle from day one. In my opinion you shouldnt go to overboard with t3 , and do really high doses since it can have a bad effect on your own t3 production. Just be careful with t3 since just like DNP can have its own dangers (not death) but read up on all the above so as to stay safe.

 

[Docd187123]

DNP is known to lower your t3, t4 production expecially on long cycle or high doses. On a short run many people choose not to add t3. After DNP your body goes back to its normal thyroid function within a week. If your doing higher doses, or are worried about a carb rebound I would suggest t3 towards the end of the cycle amongst other drugs. Some people run t3 troughout the cycle from day one. In my opinion you shouldnt go to overboard with t3 , and do really high doses since it can have a bad effect on your own t3 production. Just be careful with t3 since just like DNP can have its own dangers (not death) but read up on all the above so as to stay safe.

There is no clear proof DNP lowers T3. I experienced no such phenomenon to speak of an anecdotal reference.

 

[Docd187123]

The key point.

Anyone waiting for FDA approval to determine the safety profile of a drug....on steroid board...I can't even...no.

The authors of that rat study made it pretty clear in the supplemental material that the only thing they changed was the rate of release with the assumption that this will reduce toxicity based on an acute experiment. My hunch is that this apparent "lack of toxicity" won't play out since it is a pretty important part of what makes DNP an awesome thermogenic.

DNP is toxic because it basically acts like a metabolic poison.
Oxidative phosphorylation uncoupling to prevent oxi metabolism = reduced efficiency of ADP>ATP conversion resulting in heat & cell mitochon working harder (increased glucose uptake) = metabolism increase & ATP production via glycolysis.
The "reduced efficiency" part is irreversible and is also where the toxicity comes into play (dose dependent of course). Take this away and you end up with a safer but much less effective drug (the researchers are well aware of this) so instead its more a case of playing around with the boundaries (release rate, etc) rather than messing with the foundation itself.
Basically, its still going to be a metabolic poison but with different ranges re therapeutic/toxic dosing.

I felt like expanding on your post because I like you Doc

No worries. There aren't many things better than wakin up to a slice of Zilla in the morning with my coffee lol.

Is there an organic version of DNP?

 

[Ozzy619]

Diet. Why can't people diet?

 

[MrRippedZilla]

i want to take dnp too but i wonder how i have to eat while on it

Same diet as you would normally use when cutting (caloric deficit, high protein, alter carbs/fats at your preference keeping in mind that carbs are more useful than fats for body recomp).
The DNP itself should have no special influence on macro choices as illustrated by this paper (I have full access, for those interested PM me) that looked at high/low protein, fat or carb intakes and concluded that:
"Dinitrophenol, used in doses of therapeutic range, caused increases in metabolism of the usual magnitude irrespective diet type." - Metabolic actions of dinitrophenol with the use of balanced and unbalanced diets

also do you run t3 with your dnp ?

I personally don't see the need to run T3 with it but, at the same time, don't see a replacement dose (25mcg) hurting either since we know that t4>t3 conversion will take a hit when dieting anyway and, since your going to lose fat quicker, the DNP will accelerate this adaptation.
Basically, it depends on how long your dieting for, how long you plan on cycling DNP & so on.

Considering the evidence as a whole, I think the overall effect on thyroid is similar to that of AAS - the numbers change, the function doesn't.
Androgens reduce the concentration of TBG, DNP occupies binding proteins, both = less protein to bind to thyroid. This leads to short term thyroid dysfunction but long term a new steady state will be reached in which thyroid function is normal, despite reduced serum total T4 and total T3.
The data shows that DNP lowers protein bound iodine = increased free T4 due to protein inhibition BUT also an increased rate of T4 disappearance from circulation so the overall net change SHOULD be zero in most people.
For those that do show a significant change, and these individuals are certainly out there, I have a bunch of guesses as to why this may be but since they are only guesses I'll not bore people with them.

 

[LonelyDrug]

Same diet as you would normally use when cutting (caloric deficit, high protein, alter carbs/fats at your preference keeping in mind that carbs are more useful than fats for body recomp).
The DNP itself should have no special influence on macro choices as illustrated by this paper (I have full access, for those interested PM me) that looked at high/low protein, fat or carb intakes and concluded that:
"Dinitrophenol, used in doses of therapeutic range, caused increases in metabolism of the usual magnitude irrespective diet type." - Metabolic actions of dinitrophenol with the use of balanced and unbalanced diets



I personally don't see the need to run T3 with it but, at the same time, don't see a replacement dose (25mcg) hurting either since we know that t4>t3 conversion will take a hit when dieting anyway and, since your going to lose fat quicker, the DNP will accelerate this adaptation.
Basically, it depends on how long your dieting for, how long you plan on cycling DNP & so on.

Considering the evidence as a whole, I think the overall effect on thyroid is similar to that of AAS - the numbers change, the function doesn't.
Androgens reduce the concentration of TBG, DNP occupies binding proteins, both = less protein to bind to thyroid. This leads to short term thyroid dysfunction but long term a new steady state will be reached in which thyroid function is normal, despite reduced serum total T4 and total T3.
The data shows that DNP lowers protein bound iodine = increased free T4 due to protein inhibition BUT also an increased rate of T4 disappearance from circulation so the overall net change SHOULD be zero in most people.
For those that do show a significant change, and these individuals are certainly out there, I have a bunch of guesses as to why this may be but since they are only guesses I'll not bore people with them.

awesome thanks, you know i want to do mini cut like 2weeks dnp and then 2weeks clen, should i run t3 all 4 weeks ? or just with dnp/clen ?

 

[MrRippedZilla]

awesome thanks, you know i want to do mini cut like 2weeks dnp and then 2weeks clen, should i run t3 all 4 weeks ? or just with dnp/clen ?

You can run it all 4 weeks provided it is just a replacement dose (clen & T3 have well known synergy).

 

[S.B.C]

Judging by the huge amounts of DNP being sold by chemical manufacturers there must be shit loads of current users worldwide.

 

[GearGodess]

Did you ever take a look at the studies from the 30's that Dr Jim was talking about? Did you see how many deaths were contributed to DNP. And you still actually advocate its use for clients? That's a whole new level of stupidity. So your clients obviously lack knowledge of basic nutrition and exercise, that you should of given them, then you advise DNP for your fuk ups. I want to party with you man. Anyone recommending DNP use should be kicked in the head, and then kicked again.

You are one ignorant asshole... that's all I have to say... you're one of those people who uses supplements including AAS and thinks you don't need to do the leg work to get results, it's all magic, huh? NO? Well, you definitely sound like it!

Anything you take requires work, it doesn't happen by itself. Ever heard of the expression, "you are what you eat"? Diet is number one no matter what people end up using as an aid to reach or surpass their goals. Training is second then it's supplementation.

Maybe do a little research before you start talking shit out of your ass.... And YES I agree DNP is super dangerous but many people have used it safely with great success.

 

[hurricane]

You are one ignorant asshole... that's all I have to say... you're one of those people who uses supplements including AAS and thinks you don't need to do the leg work to get results, it's all magic, huh? NO? Well, you definitely sound like it!

Anything you take requires work, it doesn't happen by itself. Ever heard of the expression, "you are what you eat"? Diet is number one no matter what people end up using as an aid to reach or surpass their goals. Training is second then it's supplementation.

Maybe do a little research before you start talking shit out of your ass.... And YES I agree DNP is super dangerous but many people have used it safely with great success.

Yeah they use it so they don't have to diet or add extra cardio. DNP is for those wanting a short cut to fat loss. And 99.9% on this site who don't compete have no reason to fuk with this. So take your little bitch ass and fuk off. By the way the first part of your post pertained to what exactly. Where was I ever excluding hard work. So again fuk off.