The relationship between serum cholesterol and heart disease is perfectly log-linear (at least down to cholesterols of 150 or so), with correlation coefficients exceeding 0.95 in multiple studies (r2 around 0.9). Epidemiologically, heart disease mortality rises starting at about cholesterol 160 (total) or LDL about 100 in men.
You think you can manage your high cholesterol with diet alone? Ask
@Dr JIM how successful his high cholesterol patients have been when trying to lower their cholesterols with dietary therapy. I suspect he'll say not very. All doctors will tell you the same thing, and that's why their patients get the pills. It has nothing to do with pharmaceutical companies influencing doctors, either - it's human nature. The diet needed to get LDL below *safe* levels is too strict for MOST people to adhere to. We're genetically programmed to like calories - lots of calories. Nature places more importance on the avoidance of starvation than dying of an MI at 60.
You want some honest research that shows statins save lives? Here you go: The Scandinavian Simvastatin Survival Study looked at 4444 people with coronary disease and with cholesterols between 220 and 300. They were all given dietary treatment, and then further divided more or less equally into drug treatment vs non drug treatment groups. Addition of Simvastatin to diet lowered cholesterols by 25%, MI mortality by 42%, total cardiac mortality by 35%, and total mortality by 30%. NOTHING like this has ever been done with dietary therapy.
Lancet. 1995 May 20;345(8960):1274-5.
Baseline serum cholesterol and treatment effect in the Scandinavian Simvastatin Survival Study (4S)
Abstract
We examined the relation between the risk of major coronary events (coronary death and non-fatal myocardial infarction) and baseline cholesterol levels in patients with coronary heart disease, randomised to placebo or simvastatin therapy in the Scandinavian Simvastatin Survival Study (4S). The relative risk reduction in the simvastatin group was 35% (95% CI 15-50) in the lowest quartile of baseline low-density-lipoprotein cholesterol and 36% (19-49) in the highest. Simvastatin significantly reduced the risk of major coronary events in all quartiles of baseline total, high-density-lipoprotein, and low-density-lipoprotein cholesterol, by a similar amount in each quartile.