It's one year ago almost lol
MESO-Rx
Anabolic Steroids
Janoshik Analytical laboratory testing services
- Thread starter janoshik
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MyNameIsJeff
Well-known Member
Wait, so even with Janoshik's new testing method, TP's Black Tops have 98% purity and no dimer content? That's better than the competition, no?
bigboy420
Member
Are 3 tests any cheaper? And bundles here?
That is correct Jeff, now that was for batch 126. According to both test done on this batch by different facility I don't have any reason to doubt that any of his stuff has been tested by Analiza bialek are faulty. Yes better than any any competitors as of late.
MyNameIsJeff
Well-known Member
A surprise, but a welcome one. Do you know who published this test? In any case, thanks for sharing it.
No problem man .Here is the link
Thread 'TP HGH Black Tops Janoshik Test results' TP HGH Black Tops Janoshik Test results
Thread 'TP HGH Black Tops Janoshik Test results' TP HGH Black Tops Janoshik Test results
RintintinRedRocket
New Member
How long does it take for Jano to send shipping instructions after notice of payment? I requested a test and within a few minutes I received an email for payment. Made payment, notified Jano but still waiting for shipping instructions. Has only been a day but thought it would be right away after the prompt response to the testing request.
SpicyMeatball
Member
Wait 7 days then ask for a tracking number.
janoshik
Subscriber
It's Saturday, my email team doesn't work weekends. Possible you've mailed us at the end on their Friday shift.
janoshik
Subscriber
I checked and the team forgot to turn on the weekend autoreply informing clients about the fact we don't reply on the weekends - my apologies about that.
RintintinRedRocket
New Member
Thank you for the response
Ghoul
Well-known Member
@janoshik
-Have you ever been asked to measure dimer in a peptide other than HGH? I was looking for a peptide analysis result with dimer, other than HGH, but couldn't find one.
-Do aggregates larger than dimer (oligimers through visible >100um) get included in the dimer measurement, or do aggregates larger than dimer subtract from purity?
-Are samples filtered post reconstitution, prior to, what I assume(forgive me if this is wrong) is Size Exclusion Chromatography for dimer measurement?
Thanks in advance!
-Have you ever been asked to measure dimer in a peptide other than HGH? I was looking for a peptide analysis result with dimer, other than HGH, but couldn't find one.
-Do aggregates larger than dimer (oligimers through visible >100um) get included in the dimer measurement, or do aggregates larger than dimer subtract from purity?
-Are samples filtered post reconstitution, prior to, what I assume(forgive me if this is wrong) is Size Exclusion Chromatography for dimer measurement?
Thanks in advance!
janoshik
Subscriber
no
yes, but I scratched what I don't really understand/doesn't make sense
only those that exhibit anything worrying such as turbidity etc
cheers
Ghoul
Well-known Member
Thanks for the answers. I ask, in my clumsy layman's way, because I've been reading about the increasing focus of pharma manufacturers on aggregates, particularly in the context of immunogenicity developing, making peptide based therapies less effective, and in some cases causing side effects of varying degrees.
Larger aggregates appear to develop well after manufacture, as a result of packaging (the presence of silicone in auto injectors for instance) and handling (poor temperature control and shear stresses from significant agitation).
The studies looking into this either used "aged" retail, non-lypholized peptides or simulate the conditions described, allowing times of 5+ days to "incubate" for these larger aggregates to develop. So a lot of the effort to prevent aggregation has been on packaging.
Here's an illustration regarding the size classification of aggregates I was referring to:
Thanks again for indulging me, you are a unique, irreplaceable asset to this community.
Ghoul
Well-known Member
For completeness and context, here's an example of "abused" GLP-1 forming large, therapeutically inactive aggregates.
SpicyMeatball
Member
Sorry I thought I was in the qsc thread when i said this, please ignore it. Jano’s service level is different.
MyNameIsJeff
Well-known Member
Just curious: Why is it not possible to do purity testing for HCG?
janoshik
Subscriber
It is not a single molecule.
janoshik
Subscriber
That's interesting actually. I might try some runs of those on SEC for the sake of it. Thank you.
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