Joints/Tendons/Bone

Ikeda S, Kamikawa Y, Ohwatashi A, Harada K, Yoshida A. The effect of anabolic steroid administration on passive stretching-induced expression of mechano-growth factor in skeletal muscle. Scientific World Journal. 2013:313605. The Effect of Anabolic Steroid Administration on Passive Stretching-Induced Expression of Mechano-Growth Factor in Skeletal Muscle

Background. Stretching of skeletal muscle induces expression of the genes which encode myogenic transcription factors or muscle contractile proteins and results in muscle growth. Anabolic steroids are reported to strengthen muscles. We have previously studied the effects of muscle stretching on gene expression. Here, we studied the effect of a combination of passive stretching and the administration of an anabolic steroid on mRNA expression of a muscle growth factor, insulin-like growth factor-I autocrine variant, or mechano-growth factor (MGF).

Methods. Twelve 8-week-old male Wistar rats were used. Metenolone was administered and passive repetitive dorsiflexion and plantar flexion of the ankle joint performed under deep anesthesia. After 24 h, the gastrocnemius muscles were removed and the mRNA expression of insulin-like growth factor-I autocrine variant was measured using quantitative real-time polymerase chain reaction.

Results. Repetitive stretching in combination with metenolone, but not stretching alone, significantly increased MGF mRNA expression.

Conclusion. Anabolic steroids enhance the effect of passive stretching on MGF expression in skeletal muscle.
 
I'm so glad I joined this forum. All consequences that rapid muscle growth brings should be considered. Thanks for the info!
 
I am currently 5-6 weeks post surgery for a complete tendon rupture on my left armwhile benching! In late 2010 I suffered a complete tendon rupture on my right arm while benching and the weight slammed on my chest and ripped pec requiring 2 seperate surgeries! Had mri last week on right elbow cause of pain and tendon is frayed and considering having surgery and healing rehabbing over the winter! Start fresh in spring! That being said 2 n a half weeks ago started on deca with some test! Frontloaded the deca 350 mg twice 1st week! Plan on staying at 250 mg a week! Already joint pain is greatly improved and as bad as surgery was virtually no pain now! Starting off real slow as to not re injure! Have hgh comming and will start 3-4ius a day just for healing process! Asked my surgeon about it and said while he has read some on it would not say wheather he would or wouldn't if it was him! Im doing it! Simply trying to heal the best I can! I will keep you posted on results either way!
 
Oh yea fella read DOCs article carefully. The effects observed were noted as positive on SKELETAL MUSCLE and NOT the collagen protein matrix of TENDONS, and the former was KNOWN to occur long ago!
 
Jim Im going to modify my workokuts completely at the conclusion of this! Obviously heavy weight will no longer be the mainstay of my workouts! High reps less weight is the direction im going! I realize its somewhat of a gamble! I have read extensively on this not just meso! Im planning a somewhat moderate approach with the deca and the hgh! This as well as changing of my workouts seems to be my best choice imo! Ive had 20+ surgeries and breaks! Yes im no doctor but a professional patient! I know how to heal! All the signs of the tendon ruptures were there! I chose at that time to continue working out thru the pain! I knew better! We are all a little ocd in this sport! Ill fix it ive made a lifetime of comebacks!
 
i've heard that EQ actually increases tendon strength and can be stacked with test to sort of counter-act the test from impairing the tendons. was planning on including it in my next cycle when winter gets here , wanted to try a lower dose of test (500mg of Enanthate), 600mg of deca/ and a low dose of EQ to keep the tendons strong. the deca is awesome for collagen synthesis and helps with joint pain which is crucial for powerlifting ---- i found an article in my research file ..

While injecting test increases protein synthesis by roughly 50 times, depending on dose and time, most bodybuilders forget that it will reduce collagen synthesis by more than 50% -- more like 80%, giving you the collagen synthesis rate of a senior citizen. Since collagen makes up tendons, bros are very prone to injury if they continue to lift very heavy, unless they cycle off T and let their collagen synthesis get back to normal. It's like having the skeletal muscle of a gorilla with the tendons of a very old man.

Winstrol increases collagen synthesis. It will give you bigger tendons. However, your body compensates for this by making them more brittle, weaker, and more prone to injury. I can't tell you how many bros work out anaerobically and become injured while on winstrol. Guys who lift in the 1-5 rep range while on winstrol, to baseball players who sprint all out from a stationary position -- winstrol should be the LAST drug they choose. Most of them like winstrol because they don't get the weight gain from it but it is very detrimental to bros who train for any sport anaerobically. Tendons tear easily on it.

Also, the drugs I mention increase collagen synthesis while also increasing collagen cross-linking integrity, making for a much stronger tendon.

Winstrol, on the other hand, will dramatically increase collagen syn, but ironically it decreases collagen cross-linking integrity, thus making a much weaker tendon.

You can plan a cycle of AAS which will increase collagen synthesis and skeletal muscle growth at the same time. The key is the drug(s) you choose.

Deca, Equipoise, Anavar, and Primobolan will ALL increase skeletal muscle while at the same time dramatically increase collagen syn and bone mass and density, leaving you with a substantially reduced chance of becoming injured than if you choose to use AAS like sus, cyp, or enth.

While testosterone will increase bone mass and density, even at supra-physiological levels, the result is weaker tendons due to inhibition of collagen syn.

To plan a cycle where the goal is to increase skeletal muscle mass/strength while at the same time increase joint/tendon/ligament strength, enough to keep up with the dramatic increase in skeletal muscle, you must choose drugs like Eq, Deca, Anavar, or Primo as the base of your cycle. Testosterone and its esters can be added to your cycle to keep levels within a 'normal' physiological range (ie, 100-200 mg/wk) but must not go above this. Since drugs like eq, deca, anavar and primo will reduce endogenous, natural levels of test, these levels may be maintained with exogenous test in the 100-200 mg/wk range. Test at this dose will not inhibit collagen syn, but paradoxically, will help increase it. It is when exogenous testosterone is used > 200 mg/wk that collagen syn is inhibited.

Deca @ 3 mg/kg a week(about 270 mg/wk for a 200 lb male) will increase procollagen III levels by 270% by week 2. Procollagen III is a primary indicator used to determine the rate of collagen syn. As you can see, deca is a very good drug at giving you everything you want -- an increase in collagen syn, an increase in skeletal muscle, and increases in bone mass and density. The one thing it does not give you is wood.

Primobolan, @ 5 mg/kg, will increase collagen synthesis by roughly 180% -- less than deca and equipoise but still substantial.

Equipoise @ 3 mg/kg will increase procollagen III by approximately 340% -- slightly better than deca.

Oxandrolone has over a hundred studies documenting its effectiveness at treating patients needing rapid increases in collagen syn to enhance healing.

These drugs have longer half-lives than most other AAS, so this should be considered when timing your post cycle clomid use. Here they are:

Deca: 15 days Equipoise: 14 days Primobolan: 10.5 days

Anavar has a half-life of only 8 hours so it should not pose a problem.

GH is probably the most remarkable drug at increasing collagen synthesis. It increases collagen syn in a dose dependant manner -- the more you use, the more you will increase collagen syn. It has also demonstrated this ability in short and long term studies. From what I've read, hGH at 6 iu/day increased the collagen deposition rate by around 250% in damaged collagen structures. This result indicates that the increased biomechanical strength of wounds to collagen structures treated with biosynthetic human growth hormone was produced by an increased deposition of collagen in the collagen structures.

Eq, primo, anavar, and deca are all good -- they increase several biomakers of collagen syn -- ie, type III, II, I, procollagen markers. GH just seems to do so most dramatically.

Use of any of these drugs @ supra-physiological levels with a maintenance dose of test will increase collagen syn while at the same time increase skeletal muscle mass. Skeletal muscle mass gains will not be as dramatic as with large testosterone doses but you have to weigh the risk/reward basis for yourself. Also, these drugs do not satisfy the libido like testosterone, but that is not the point of this thread. It is only to demonstrate that you can increase skeletal muscle and collagen syn at the same time with certain AAS --
i clicked on a link from here i dont want to advertise but heres the link What is Equipoise? | eHow.com

Thank you for taking the time to post this. Have bad knees, doc stated to go to PT to build up the muscle around the knees. But during the MRI they stated that my tendons were showing mucoid. After 6 months of PT still having pain behind the knees mainly the tendon area. I am just over 40, so thinking that a Deca may be of help here. Again thx for the post, this is very informative!
 
Drs or anyone! I have started benching again lightly 135 20- 30 reps and no pain in elbow but puffy swelling about like half a golf ball! Started smaller and has gotten bigger the more ive lifted with it! Its like a bursa sack! What can I do for it?
 
Drs or anyone! I have started benching again lightly 135 20- 30 reps and no pain in elbow but puffy swelling about like half a golf ball! Started smaller and has gotten bigger the more ive lifted with it! Its like a bursa sack! What can I do for it?

Well for starters stop lifting Searay!!
 
Sounds like olecronon bursitis providing: there is NO HISTORY of impact trauma, the pain is minimal, the ROM is NORMAL and the swelling is limited to the backside (posterior extensor surface) of the ELBOW joint.

Posting a PIC would be very useful.

Treatment consists of FIRST a proper diagnosis and IF OC is confirmed REST (yup stop lifting duh), ICE and compression with a SNUG fitting ace wrap.

NOW dude don't go nuts and believe by "snug fitting" I mean it's so tight your hand goes numb, NOT lol!

Oftentimes the swelling diminishes remarkably with the compressive wrap alone, which may be diagnostic of this condition alone (assuming apropos history)!

Jim
 
Thanks Dr jim! As I stated earlier in this thread I had surgery last week of august on complete tendon rupture! You predicted based on my history another future rupture! Lifting lightly now virtually no pain but on inside of elbow started swelling now bigger! Still no pain lifting! ive iced it everyday since my surgery! I will ease up! But like I said its on inside tip just north of elbow! Ill work on getting pic of it! Thnx!
 
Wait a minute!

Is this the elbow in which you tore the distal biceps tendon AND had it surgically repaired?

If so how long ago was it repaired?

Be specific about the activities your surgeon has cleared you for!

Fella if there is ANY swelling, tenderness or discomfort about this most recent surgical incision site STOP LIFTING immediately,

Thereafter seek your surgeons opinion because if you are shearing (tearing) that tendon you could fuck it up BEYOND REPAIR. (Sorry to be blunt but !!)

Jim
 
Wait a minute!

Is this the elbow in which you tore the distal biceps tendon AND had it surgically repaired?

If so how long ago was it repaired?

Be specific about the activities your surgeon has cleared you for!

Fella if there is ANY swelling, tenderness or discomfort about this most recent surgical incision site STOP LIFTING immediately,

Thereafter seek your surgeons opinion because if you are shearing (tearing) that tendon you could fuck it up BEYOND REPAIR. (Sorry to be blunt but !!)

Jim

It was the tricep tendon and yes its the same arm! 10 weeks ago was surgery! He only cleared me to start physical therepy! Had a follow up appointment last week and said it looked good altho bump was half the size then! I will cool it! You can be blunt I can take an ass ripping when I deserve one! But really no pain at all! Just this golf ball size bump and since it was on inside thought it was ok! He didnt seem concerned!
 
The orgin/insertion of the triceps tendon is located exactly at the site your describing has swelling!

Are you NUTS fella really?

Resistance lifting earlier than the optimal post operative time period (3-6months depending upon the surgical repair utilized) STRETCHES THE SURGICALLY REPAIRED STRUCTURES and WEAKENS the FUNCTIONAL ANATOMY!

The net effect? ANOTHER TORN TENDON but this time at a previously "repaired" site.

The outcome in the latter circumstance is RARELY as good as the first repair.

Consequently because most surgeons take great pride in their patients outcomes, I would BE LIVID if I knew you had already returned to the gym and was involved in AROM resistance exercises especially without my clearance!

Get the hell out of that gym and FU with the PT as your doc suggested or screw up your elbow permanently,
and if that's your desire why on Gods green earth did you have the repair from the outset, COL!
 
The orgin/insertion of the triceps tendon is located exactly at the site your describing has swelling!

Are you NUTS fella really?

Resistance lifting earlier than the optimal post operative time period (3-6months depending upon the surgical repair utilized) STRETCHES THE SURGICALLY REPAIRED STRUCTURES and WEAKENS the FUNCTIONAL ANATOMY!

The net effect? ANOTHER TORN TENDON but this time at a previously "repaired" site.

The outcome in the latter circumstance is RARELY as good as the first repair.

Consequently because most surgeons take great pride in their patients outcomes, I would BE LIVID if I knew you had already returned to the gym and was involved in AROM resistance exercises especially without my clearance!

Get the hell out of that gym and FU with the PT as your doc suggested or screw up your elbow permanently,
and if that's your desire why on Gods green earth did you have the repair from the outset, COL!

Point taken and consider it done!
 
Sounds like olecronon bursitis providing: there is NO HISTORY of impact trauma, the pain is minimal, the ROM is NORMAL and the swelling is limited to the backside (posterior extensor surface) of the ELBOW joint.

Posting a PIC would be very useful.

Treatment consists of FIRST a proper diagnosis and IF OC is confirmed REST (yup stop lifting duh), ICE and compression with a SNUG fitting ace wrap.

NOW dude don't go nuts and believe by "snug fitting" I mean it's so tight your hand goes numb, NOT lol!

Oftentimes the swelling diminishes remarkably with the compressive wrap alone, which may be diagnostic of this condition alone (assuming apropos history)!

Jim

While im still going to refrain from lifting wearing the ace bandage reduced bump by 80 percent! I have continually iced since surgery! Why does the bandage work? With it off it slowly grows in size!
 
You have probably developed a reactive "seroma" and no DOUBT have contributed to a more localized inflammatory process because you returned to the gym prematurely.

However because inflammation in general opens the vascular pores of the area involved this process does and should (more or less depending upon primary causation) respond to the measures I mentioned earlier; ice, compression, elevation and timely rest.

However if you believe this swelling is primarily due to "over doing it" rather than the distinct possibility of a disrupted surgical repair, WE, I, YOU now know exactly WHY your prior surgical outcomes have been much less than optimal, arrogant stupidity!
 
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