Studious69
New Member
I think it’s widely known anabolic and androgens have a deleterious effect on lipid profiles in users. Why does this occur in the human body? What about these compounds causes the effect on lipids?
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With respect to lowering HDL-C, this ↓ is caused by an ↑ hepatic triglyceride lipase activity (HTGLA). Hepatic lipase (HL) is a liver-secreted enzyme that liberates FAs from lipoprotein constitutents (e.g., including HDL), therefort this induces a shift towards breakdown ∴ reduced HDL.
The 17AAs, because they are either nonaromatizable or resistant to aromatization and thus lack estrogen benefits to lipids (estrogens ↓HTGLA), and because they are metabolized primarily in liver, having greater effects on hepatic proteins (e.g., HL), are worse than parenteral androgens (especially T).
With respect to increasing LDL, 17AAs may ↑Apo B in particular, which is associated with VLDL & gives insight into LDL actually in bloodstream circulation, perhaps by ↑ liver secretion of these lipoproteins directly.
beautifully answered!! Paper will be read tomorrow.From Oral Steroid and Cholesterol:
Here is a great Table summarizing the effects of AAS (17AAs & i.m.) on lipoproteins and cholesterol efflux capacity (CEC) associated with CVD risk. I urge you to read this great paper: [link] for more information about your questions in this thread.
View attachment 261346
Although, initially I see above it states 17-aa compounds are either nonaromatizable or resistant… what about something like dianabol? Methylestradiol I believe being the e2 converted from dbol in the body.From Oral Steroid and Cholesterol:
Here is a great Table summarizing the effects of AAS (17AAs & i.m.) on lipoproteins and cholesterol efflux capacity (CEC) associated with CVD risk. I urge you to read this great paper: [link] for more information about your questions in this thread.
View attachment 261346
Although, initially I see above it states 17-aa compounds are either nonaromatizable or resistant… what about something like dianabol? Methylestradiol I believe being the e2 converted from dbol in the body.