My Thoughts on GH

[bluzzer]

Some science does say that BUT that falls under lipolysis (fat reduction) if true.

The real magic of GH seems in my experiences to be its effects on inhibiting lipogenesis (fat formation). Unfortunately you need a degree in biochemistry to understand the significance of the mechanisms involved in how HGH does that, but the study below suggests a mechanism of how it achieves this:

Effects of exogenous growth hormone on lipid metabolism in the isolated epididymal fat pad of the growth hormone-deficient little mouse​

F M Ng 1, N A Adamafio, J E Graystone
Affiliations expand

• PMID: 1969738
• 
  
• DOI: 10.1677/jme.0.0040043

Abstract​

The effects of two preparations of highly purified human GH (hGH) on lipid metabolism were studied in the GH-deficient little mouse (50-60 days old). Marked decreases in incorporation of [14C]glucose into fatty acid and in the activity of acetyl-CoA carboxylase in the epididymal fat pads were observed after i.p. injection of hGH at a dose of 1.0 microgram/g body weight or after continuous infusion of hGH by osmotic minipump. The rate of glucose incorporation into fatty acid decreased from 107.0 +/- 27.6 (S.E.M.) to 38.1 +/- 19.6 mumol/g tissue per h after a single injection of hGH and from 174.1 +/- 28.5 to 56.3 +/- 20.3 mumol/g tissue per h after continuous infusion of hGH for 2 days. Activity of the lipogenic enzyme acetyl-CoA carboxylase was also reduced by more than 50% in the epididymal fat pad from hGH-treated mice in comparison with the corresponding control animals. Incubation of isolated fat pads with hGH (0.1 microgram/ml) revealed similar inhibitory effects of the hormone on fatty acid synthesis and acetyl-CoA carboxylase activity. No lipolytic effect of hGH was found as determined by the rate of glycerol release from epididymal fat pads of little mice following hormone treatment in vivo or in vitro. The results lend strong support to the conclusion that GH inhibits lipogenesis but has no effect on lipolysis in adipose tissues, and indicate that the physiological role of GH in lipid metabolism is concerned mainly with the regulation of anabolic rather than catabolic processes.

So in the above study GH inhibits lipogenesis by reducing the levels of some enzyme that, apparently, is involved in the process of fat formation. Interestingly the above study also notes no benefit from GH on actual lipolysis (they observed no effect on increasing fat burning) rather the primary benefit seemed to be on preventing fat storage to begin with. This studies results parallel my own observations personally using GH.

My question becomes, if GH inhibits this enzyme from synthesizing fat tissue during a caloric surplus what is the fate of all those excess calories that otherwise would have gone towards fat storage? Does it mean they instead end up going towards additional muscle growth provided the stimulus for muscle growth is present? Is this what bros mean when they talk about enhanced nutrient partitioning?

This is interesting!

Or maybe it ends up as additional glycogen stored in muscles. We all know that GH can cause water retention

 

[MFAAS]

My question becomes, if GH inhibits this enzyme from synthesizing fat tissue during a caloric surplus what is the fate of all those excess calories that otherwise would have gone towards fat storage? Does it mean they instead end up going towards additional muscle growth provided the stimulus for muscle growth is present? Is this what bros mean when they talk about enhanced nutrient partitioning?

I was thinking the exact same thing.

Does it go towards muscle building? Does it just get stored in muscle as glycogen (hence the temporary "3D Effect" people mention) and then get released as GH goes down?

Does it exit the body as heat? It would've been nice if they took the temperature of the mice.

It has to go somewhere.

 

[Jaxino]

I haven't been on deficit. around 4000-4500 kcal ED.


75 iu Lantus
and
10-12 iu fast acting insulin around workout.

I don't know mate i was so convinced that Lantus made me fat.... and i was eating high carb minimal fat diet... 4k cals too maybe my hgh is not good as yours....

 

[bluzzer]

I don't know mate i was so convinced that Lantus made me fat.... and i was eating high carb minimal fat diet... 4k cals too maybe my hgh is not good as yours....

I ran out of hgh some time ago and then the lantus made me store fat.

 

[Deleted member 123722]

Some science does say that BUT that falls under lipolysis (fat reduction) if true.

The real magic of GH seems in my experiences to be its effects on inhibiting lipogenesis (fat formation). Unfortunately you need a degree in biochemistry to understand the significance of the mechanisms involved in how HGH does that, but the study below suggests a mechanism of how it achieves this:

Effects of exogenous growth hormone on lipid metabolism in the isolated epididymal fat pad of the growth hormone-deficient little mouse​

F M Ng 1, N A Adamafio, J E Graystone
Affiliations expand

• PMID: 1969738
• 
  
• DOI: 10.1677/jme.0.0040043

Abstract​

The effects of two preparations of highly purified human GH (hGH) on lipid metabolism were studied in the GH-deficient little mouse (50-60 days old). Marked decreases in incorporation of [14C]glucose into fatty acid and in the activity of acetyl-CoA carboxylase in the epididymal fat pads were observed after i.p. injection of hGH at a dose of 1.0 microgram/g body weight or after continuous infusion of hGH by osmotic minipump. The rate of glucose incorporation into fatty acid decreased from 107.0 +/- 27.6 (S.E.M.) to 38.1 +/- 19.6 mumol/g tissue per h after a single injection of hGH and from 174.1 +/- 28.5 to 56.3 +/- 20.3 mumol/g tissue per h after continuous infusion of hGH for 2 days. Activity of the lipogenic enzyme acetyl-CoA carboxylase was also reduced by more than 50% in the epididymal fat pad from hGH-treated mice in comparison with the corresponding control animals. Incubation of isolated fat pads with hGH (0.1 microgram/ml) revealed similar inhibitory effects of the hormone on fatty acid synthesis and acetyl-CoA carboxylase activity. No lipolytic effect of hGH was found as determined by the rate of glycerol release from epididymal fat pads of little mice following hormone treatment in vivo or in vitro. The results lend strong support to the conclusion that GH inhibits lipogenesis but has no effect on lipolysis in adipose tissues, and indicate that the physiological role of GH in lipid metabolism is concerned mainly with the regulation of anabolic rather than catabolic processes.

So in the above study GH inhibits lipogenesis by reducing the levels of some enzyme that, apparently, is involved in the process of fat formation. Interestingly the above study also notes no benefit from GH on actual lipolysis (they observed no effect on increasing fat burning) rather the primary benefit seemed to be on preventing fat storage to begin with. This studies results parallel my own observations personally using GH.

My question becomes, if GH inhibits this enzyme from synthesizing fat tissue during a caloric surplus what is the fate of all those excess calories that otherwise would have gone towards fat storage? Does it mean they instead end up going towards additional muscle growth provided the stimulus for muscle growth is present? Is this what bros mean when they talk about enhanced nutrient partitioning?

They have to go somewhere, so if not fat, probably within the muscle as glycogen. I don't think the body would spend extra energy building new tissue because of it, but would just shove it in the glycogen stores?

 

[Roco Bama]

This is what guys call the “3D effect”. It is similar to what i get with large doses of creatine. However just like creatine its temporary only for as long as you continue using it.

Ive personally never found GH to be a mass builder. Ive used it with slin and i did bulk up sarcoplasm really fast though but i credit that with the insulin not the GH. On a cost:effect ratio verse AAS GH is a bad investment if muscle gains is the only goal.

Where ive found GH to be most impressive is its inhibition of lipogenesis when consuming a huge surplus. Many bros report the same thing, they can go on a crazy bulking surplus and somehow not gain fat. Now im an ectomorph so getting fat seems impossible, so i may not be the best candidate for reporting this benefit as i dont get fat on any surplus even without GH. If you are an endomorph and need to be very careful with cal intake when bulking i think GH would be a huge help to utilize on a bulk, not becuse its going to super charge your gainz but rather because it will minimize your fat gains letting you intake a bigger surplus which will help your muscle gains.

What i dont understand is what GH does exactly that prevents excess calories from getting stored as fat. I think guys like to call it enhanced nutrient partitioning, it just seems to change the way the body reacts to excess caloric surplus.

I also think the older you are the better the benefits will be from GH, so bros in their 40s and 50s probably stand to gain more from using GH verse younger guys.

It is definitely no miracle mass gainer though, anyone going into it with that expectation is definitely setting themselves up for disappointment in my experience.

Some AAS also have this inhibitory effect on lipogenesis. I stay lean on a caloric surplus when taking either anavar, tren or masterone and others on this site have reported primo having the same effect.

 

[Cashton]

Well, I don't think Dorian lied about this gear usage. He said he took 1g of test and 500 deca, and I believe 8ius of GH. He touched slin later in his career and actually hated it, saying it added size but it wasn't quality. And you could tell when he did, because he looked like crap.

I wouldn't under estimate genetics; they are people who compete that don't take slin at all.

Do you believe Dorian Yates took under 2g of anabolics for his career?

 

[Deleted member 123722]

You believe Dorian Yates took under 2g of anabolics for his career?….

Why would he lie? Of all the liars out there, Dorian is the one who doesn't seem to lie. In fact, he never backed down from his extremely politically incorrect views of the Holocaust, you know, that one event which can land you in jail or fined in 19 countries in Europe for even questioning a single aspect of it, which ends careers and destroys people's lives lol. So why would he be open about his disbelief in certain aspects of an event which can land you in prison, and not apologize to the world like every other cuck would, but lie about his gear when he is not required to lie due to any sponsorship or living in a country where usage is illegal?

My one friend who is an IFBB pro, never goes past 750 test...Idk about his other compounds, but I knew people who responded to low dosages. Being that Dorian and the other Olympians are literally the elite on PLANET EARTH, they will respond better to drugs and than others. That is not to say that there aren't some out there who require higher dosages due to their response. Moreover, the offseason, from what I understand, doesn't require as much drugs as the contest prep. I've only seen Dorian talk about what he took off season. He admitted taking insulin later in his career, which he said gave him shitty quality gains.

There's a few bbuilders who claim low dosagse and have no reason to lie. Lee Priest come to mind as well. But then you got retards like Mike O Tren who deny it completely.

 

[Cashton]

Why would he lie? Of all the liars out there, Dorian is the one who doesn't seem to lie. In fact, he never backed down from his extremely politically incorrect views of the Holocaust, you know, that one event which can land you in jail or fined in 19 countries in Europe for even questioning a single aspect of it, which ends careers and destroys people's lives lol. So why would he be open about his disbelief in certain aspects of an event which can land you in prison, and not apologize to the world like every other cuck would, but lie about his gear when he is not required to lie due to any sponsorship or living in a country where usage is illegal?

My one friend who is an IFBB pro, never goes past 750 test...Idk about his other compounds, but I knew people who responded to low dosages. Being that Dorian and the other Olympians are literally the elite on PLANET EARTH, they will respond better to drugs and than others. That is not to say that there aren't some out there who require higher dosages due to their response. Moreover, the offseason, from what I understand, doesn't require as much drugs as the contest prep. I've only seen Dorian talk about what he took off season. He admitted taking insulin later in his career, which he said gave him shitty quality gains.

There's a few bbuilders who claim low dosagse and have no reason to lie. Lee Priest come to mind as well. But then you got retards like Mike O Tren who deny it completely.

Ifbb pro who only takes 750mg of test.. unless he’s using 1-2g+ of deca, tren and or eq.. homeboy is lying to you.. or you’re lying to us.. one or the other.. unless it’s a girl? Lol

 

[Deleted member 123722]

Ifbb pro who only takes 750mg of test.. unless he’s using 1-2g+ of deca, tren and or eq.. homeboy is lying to you.. or you’re lying to us.. one or the other.. unless it’s a girl? Lol

well he never mentioned the other gear doses lol.

 

[Jaxino]

Ifbb pro who only takes 750mg of test.. unless he’s using 1-2g+ of deca, tren and or eq.. homeboy is lying to you.. or you’re lying to us.. one or the other.. unless it’s a girl? Lol

Maybe he is a men's physique, or a short guy...

 

[Deleted member 123722]

Instagram

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[Type-IIx]

This is what guys call the “3D effect”. It is similar to what i get with large doses of creatine. However just like creatine its temporary only for as long as you continue using it.

Ive personally never found GH to be a mass builder. Ive used it with slin and i did bulk up sarcoplasm really fast though but i credit that with the insulin not the GH. On a cost:effect ratio verse AAS GH is a bad investment if muscle gains is the only goal.

Where ive found GH to be most impressive is its inhibition of lipogenesis when consuming a huge surplus. Many bros report the same thing, they can go on a crazy bulking surplus and somehow not gain fat. Now im an ectomorph so getting fat seems impossible, so i may not be the best candidate for reporting this benefit as i dont get fat on any surplus even without GH. If you are an endomorph and need to be very careful with cal intake when bulking i think GH would be a huge help to utilize on a bulk, not becuse its going to super charge your gainz but rather because it will minimize your fat gains letting you intake a bigger surplus which will help your muscle gains.

What i dont understand is what GH does exactly that prevents excess calories from getting stored as fat. I think guys like to call it enhanced nutrient partitioning, it just seems to change the way the body reacts to excess caloric surplus.

I also think the older you are the better the benefits will be from GH, so bros in their 40s and 50s probably stand to gain more from using GH verse younger guys.

It is definitely no miracle mass gainer though, anyone going into it with that expectation is definitely setting themselves up for disappointment in my experience.

The anti-adipogenic and lipolytic mechanisms of GH include:
- binding directly to adipocytes, increasing the fat cell's sensitivity to catecholamines, i.e., encouraging lipolysis.
- blocking differentiation of adipocytes (stops the formation of body fat). In already existing fat cells, GH inhibits glucose uptake and lipogenesis. IGF-I acts in a manner that actually increases the pool of undifferentiated cells that 'could' create fat cells, but hGH acts in opposition to both the formation of new fat cells and the storage of energy therein.
- increases hormone-sensitive lipase (1-2 hr post-injection) activity, and increases HSL gene expression.
- upregulates uncoupling protein expression (e.g., UCP2)
- beta1- and beta3- adrenergic activation

 

[Dead]

I'm on my last kit of Goodlyfe HGH, which is quite affordable and those of who have taken it, know it's good to go, but after watching this video
View: https://youtu.be/5F7m8RHf2ZA
and taking GH on and off for years, both pharm and generic of various kinds, I have to agree with Iain in this video, that it may help 5% more and you shoudln't take it unless you have disposable income, and its better to use your money on food and gear in regards to muscle growth.

Even though Goodlyfe is affordable and is good, I'm not a pro, nor am I competitor, and frankly, I don't think it's even necessary because the kind of physique I would like to accomplish, doesn't need GH anyway. My levels at 5ius came back at 371, and other times I've taken different brans, 299 or 384. Nothing crazy. I'd have to be taken 10ius to get higher levels lol. So clearly, my body must suck at converting exogenous GH. I have done IGF-1 Lr3 before, and completely transformed, but I was also on gear then (var and tren), so how do I know it was the IGF-1, especially when tren increase IGF-1? I got really lean on it, but people say at best its a GDA.

And I wonder, if GH is just something people think they need, but doesn't do what they think. We know Growth Hormone doesn't actually build tissue, rather it is the IGF-1. And we also know, its not even the IGF-1, rather, it's the MGF that comes from IGF-1, which happens in the cell after training; and we know we can't shoot MGF exogenously, because it doesn't work for some reason.

So what do we take GH for? Fat burning, anti-aging, rest, recovery? Perhaps tendon growth, intermuscular water retention? Well I think you get better fat burning from clen/t3 combo, and I'm sure the rest can be achieved by other means as well.

I've been on GH for nearly a year straight now, and all I've noticed is that I sleep way better; fat burning, maybe it's kept me lean a bit since I'm not doing any cardio or really dieting. Recovery? Eh, that depends on my volume and intensity.

Maybe it is the icing on the cake, and maybe at high levels of competition you need it because you're maxed out on gear and genetics, but I certainly am not, and maybe its time to let it go lol.

I'm gonna blast 10iu ED to see if I notice anything crazy, until this kit runs out and then give myself a break

Anyone else come to the same conclusion?

What do you mean by transformed

 

[Deleted member 123722]

The anti-adipogenic and lipolytic mechanisms of GH include:
- binding directly to adipocytes, increasing the fat cell's sensitivity to catecholamines, i.e., encouraging lipolysis.
- blocking differentiation of adipocytes (stops the formation of body fat). In already existing fat cells, GH inhibits glucose uptake and lipogenesis. IGF-I acts in a manner that actually increases the pool of undifferentiated cells that 'could' create fat cells, but hGH acts in opposition to both the formation of new fat cells and the storage of energy therein.
- increases hormone-sensitive lipase (1-2 hr post-injection) activity, and increases HSL gene expression.
- upregulates uncoupling protein expression (e.g., UCP2)
- beta1- and beta3- adrenergic activation

It all sounds good, but is it worth the money when you could spend less on t3 etc. Again, for the price we can get decent generics for its not insane, but we've seen plenty of old school BBers build great physiques without it. I'm not trying to be a mass monster.

 

[Deleted member 123722]

What do you mean by transformed

I was lean, vascular, and veiny like never before. But again, I was on var, test and tren, but not crazy doses at all. 40mg var, 200 cyp 200 tren, if I remember correctly

 

[Roco Bama]

It all sounds good, but is it worth the money when you could spend less on t3 etc. Again, for the price we can get decent generics for its not insane, but we've seen plenty of old school BBers build great physiques without it. I'm not trying to be a mass monster.

Our body has evolved an antistarvation mechanism for holding on to fat as much as possible as this traits helped our ancestors survive when food was scarce. So when it comes to shedding fat, even taking every fat burning hormones that exist won't yield good results unless you're burning more calories than you eat.

 

[Deleted member 123722]

Our body has evolved an antistarvation mechanism for holding on to fat as much as possible as this traits helped our ancestors survive when food was scarce. So when it comes to shedding fat, even taking every fat burning hormones that exist won't yield good results unless you're burning more calories than you eat.

Well let's take me for example.

My IGF1 levels on 5iu ed of Goodlyfe came back 371; I only took 2.5 ius the morning of the bloodwork... I was thinking, if I wanted to get super-high levels of IGF1, I'd have to take 10iu a day to yield maybe 700 or so...and that would run me like 330 a month. Might as well get pharm grade at that point... but then the question is, would I convert the same .74 per IU and just spend way more?

Now, as for fat burning, I've certainly never gained any fat back since my recomp, and keep changing, albeit slowly.

But at teh end of the day, I agree with Iain and several others who say GH obviously will help, but not as insanely drastic and people expect, and can get expensive.

 

[Roco Bama]

Well let's take me for example.

My IGF1 levels on 5iu ed of Goodlyfe came back 371; I only took 2.5 ius the morning of the bloodwork... I was thinking, if I wanted to get super-high levels of IGF1, I'd have to take 10iu a day to yield maybe 700 or so...and that would run me like 330 a month. Might as well get pharm grade at that point... but then the question is, would I convert the same .74 per IU and just spend way more?

Now, as for fat burning, I've certainly never gained any fat back since my recomp, and keep changing, albeit slowly.

But at teh end of the day, I agree with Iain and several others who say GH obviously will help, but not as insanely drastic and people expect, and can get expensive.

I ran 15iu-5iu of HGH for 1 year straight and I did blood work to confirm it was legit but that cycle turned out to be a waste of money. I gained no noticable results from it and I didn't lose any fat on it. Like you said earlier, if you aren't GH deficient or you aren't a pro bodybuilder, I don't see a reason to waste your money on HGH.

 

[Deleted member 123722]

I ran 15iu-5iu of HGH for 1 year straight and I did blood work to confirm it was legit but that cycle turned out to be a waste of money. I gained no noticable results from it and I didn't lose any fat on it. Like you said earlier, if you aren't GH deficient or you aren't a pro bodybuilder, I don't see a reason to waste your money on HGH.

wow