I am sure it is only a matter of time before the GLP1 people go completely off the rails into rank stupidity.
"but, but, but guys, I can't control my 'food noise' and my cravings. I am currently taking 200 MG a week between sema, tirz and reta but I am still gaining weight. So I guess now I will add low dose meth and bathtub crank to my stack to snort lines of to really take me to the next level." I am only half kidding, as I expect that market for hardcore stims to take off once people start failing on GLP1's over time (and they will).
Some people just aren't cut out for this shit. Some people are just plain fucking weak. Mentally, physically, and otherwise. Not nice to say perhaps but that is how I have always sized it up.