kiwigear
New Member
Dylan gemelli signing off.. Cock sucker he is
MESO-Rx
Anabolic Steroids
SARMS...are they legit?
- Thread starter Alfirk Recomim
- Start date
Sector51
New Member
Oh good Lord! Who really wants to look like that
kiwigear
New Member
Little scrawny cunt looks like he brought that punisher shirt at baby GAPOh good Lord! Who really wants to look like that
Sector51
New Member
Just to look tough, hahaha
kiwigear
New Member
Tough.. At a whole 95 pounds with flexed 8s lol
Sector51
New Member
Looks like a schoolyard bully lmfao
kiwigear
New Member
Lol school yard.. Bitch would get stepped out by kindy kids lol.. That's wen he can get off his knees from blowing rick rock and the rest of the adrenaline rush homo bukakke squad
RockoJocko
New Member
I have searched the Science Direct database (similar to PubMed) and have not found anything significant regarding evidence the SARM's are directly responsible for muscle hypertrophy, except in one study on mice whereby the specific SARM actually decreased testosterone (prostate enlargement etc) while actually having what I interpreted as an "anabolic" affect on the muscle. Another study was on a different SARM that studied testosterone and specific SARM's equal influence on specific markers: Both Abstracts are here - if any "science" minded person would like to see the full article of either one, PM me.
MK-4541
A novel selective androgen receptor modulator (SARM) MK-4541 exerts anti-androgenic activity in the prostate cancer xenograft R–3327G and anabolic activity on skeletal muscle mass & function in castrated mice
Abstract
The androgen receptor (AR) is a member of the nuclear hormone receptor super family of transcription factors. Androgens play an essential role in the development, growth, and maintenance of male sex organs, as well as the musculoskeletal and central nervous systems. Yet with advancing age, androgens can drive the onset of prostate cancer, the second leading cause of cancer death in males within the United States. Androgen deprivation therapy (ADT) by pharmacologic and/or surgical castration induces apoptosis of prostate cells and subsequent shrinkage of the prostate and prostate tumors. However, ADT is associated with significant musculoskeletal and behavioral adverse effects. The unique pharmacological activity of selective androgen receptor modulator (SARM) MK-4541 recently has been reported as an AR antagonist with 5α-reductase inhibitor function. The molecule inhibits proliferation and induces apoptosis in AR positive, androgen dependent prostate cancer cells. Importantly, MK-4541 inhibited androgen-dependent prostate growth in male rats yet maintained lean body mass and bone formation following ovariectomy in female rats. In the present study, we evaluated the effects of SARM MK-4541 in the androgen-dependent Dunning R3327-G prostate carcinoma xenograft mouse model as well as on skeletal muscle mass and function, and AR-regulated behavior in mice. MK-4541 significantly inhibited the growth of R3327-G prostate tumors, exhibited anti-androgen effects on the seminal vesicles, reduced plasma testosterone concentrations in intact males, and inhibited Ki67 expression. MK-4541 treated xenografts appeared similar to xenografts in castrated mice. Importantly, we demonstrate that MK-4541 exhibited anabolic activity in androgen deficient conditions, increasing lean body mass and muscle function in adult castrated mice. Moreover, MK-4541 treatment restored general activity levels in castrated mice. Thus, MK-4541 exhibits an optimum profile as an adjuvant therapy to ADT which may provide potent anti-androgenic activity at the prostate yet protective activity on skeletal muscle and behavior in patients
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-second SARM and abstract below
LGD2941
MK-4541
A novel selective androgen receptor modulator (SARM) MK-4541 exerts anti-androgenic activity in the prostate cancer xenograft R–3327G and anabolic activity on skeletal muscle mass & function in castrated mice
Abstract
The androgen receptor (AR) is a member of the nuclear hormone receptor super family of transcription factors. Androgens play an essential role in the development, growth, and maintenance of male sex organs, as well as the musculoskeletal and central nervous systems. Yet with advancing age, androgens can drive the onset of prostate cancer, the second leading cause of cancer death in males within the United States. Androgen deprivation therapy (ADT) by pharmacologic and/or surgical castration induces apoptosis of prostate cells and subsequent shrinkage of the prostate and prostate tumors. However, ADT is associated with significant musculoskeletal and behavioral adverse effects. The unique pharmacological activity of selective androgen receptor modulator (SARM) MK-4541 recently has been reported as an AR antagonist with 5α-reductase inhibitor function. The molecule inhibits proliferation and induces apoptosis in AR positive, androgen dependent prostate cancer cells. Importantly, MK-4541 inhibited androgen-dependent prostate growth in male rats yet maintained lean body mass and bone formation following ovariectomy in female rats. In the present study, we evaluated the effects of SARM MK-4541 in the androgen-dependent Dunning R3327-G prostate carcinoma xenograft mouse model as well as on skeletal muscle mass and function, and AR-regulated behavior in mice. MK-4541 significantly inhibited the growth of R3327-G prostate tumors, exhibited anti-androgen effects on the seminal vesicles, reduced plasma testosterone concentrations in intact males, and inhibited Ki67 expression. MK-4541 treated xenografts appeared similar to xenografts in castrated mice. Importantly, we demonstrate that MK-4541 exhibited anabolic activity in androgen deficient conditions, increasing lean body mass and muscle function in adult castrated mice. Moreover, MK-4541 treatment restored general activity levels in castrated mice. Thus, MK-4541 exhibits an optimum profile as an adjuvant therapy to ADT which may provide potent anti-androgenic activity at the prostate yet protective activity on skeletal muscle and behavior in patients
--------------------------------------------------------------------------------------------------
-second SARM and abstract below
LGD2941
- Influence of testosterone and a novel SARM on gene expression in whole blood of Macaca fascicularis (monkeys)
- Abstract
Anabolic hormones, including testosterone, have been suggested as a therapy for aging-related conditions, such as osteoporosis and sarcopenia. These therapies are sometimes associated with severe androgenic side effects. A promising alternative to testosterone replacement therapy are selective androgen receptor modulators (SARMs). SARMs have the potential to mimic the desirable central and peripheral androgenic anabolic effects of testosterone without having its side effects.
In this study we evaluated the effects of LGD2941, in comparison to testosterone, on mRNA expression of selected target genes in whole blood in an non-human model. The regulated genes can act as potential blood biomarker candidates in future studies with AR ligands.
Cynomolgus monkeys (Macaca fascicularis) were treated either with testosterone or LGD2941 for 90 days in order to compare their effects on mRNA expression in blood. Blood samples were taken before SARM application, on day 16 and on day 90 of treatment.
Gene expression of 37 candidate genes was measured using quantitative real-time RT-PCR (qRT-PCR) technology.
Our study shows that both testosterone and LGD2941 influence mRNA expression of 6 selected genes out of 37 in whole blood. The apoptosis regulators CD30L, Fas, TNFR1 and TNFR2 and the interleukins IL-12B and IL-15 showed significant changes in gene expression between control and the treatment groups and represent potential biomarkers for androgen receptor ligands in whole blood.
I bet if he turned around he would have one of those man buns in his hair.
He is implying that they ligitmately are shitty; not legitimately THE shit.
FYI
GearGodess
Well-known Member
Sorry to wake this up but I had to see for myself... so I joined to see all this godly talk about these amazing sarms on that forum which IMO are all a waste of time and money. Hell, Dylan's physique should give you a good indication of how well they work... anyone who buys his bullshit should be punched in the sack and face! lol... sorry.... not to mention, his top most regarded source is one and only Phurious/Krazie... that alone should say a ton! lmao
What I also found funny, which shows you how bad they push this crap there, if you dare to say to any member to stay away from any cycles if they are brand new to training. For example, there was a guy who wants to add mass as his very first cycle. His diet is OK but he just started training... right away the sarms vets/shills gave him a run down of at least 7-8 different compounds and doses and said, run this now and you will get huge and lean. GIVE ME A FRIGGIN BREAK! So I couldn't watch it anymore and posted, "why don't you fools care about his well being and getting his diet and training solid first before introducing any supplementation. the OP isn't ready for it. He's only started working out 6 months ago" I believe. - well, to my surprise, my comment/post was deleted... so I replied again and said, "OP please give your body a chance to develop naturally and get your training and diet in check first. Then think about what you want to accomplish. Running sarms or gear at this stage should be the last thing on your mind." - again it got deleted. So I posted the third time and simply told them that this is F@#$ed up for them deleting posts without any reason, besides the fact that he should not be wasting money on sarms and he should spend his money wisely on proper food. - once again it got deleted and then I guess they blocked me as I am unable to post... that place is definitely a joke! Plus many people that post there sound as if they are scripted posts. It's very odd... Oh, and there was another post from a guy who said he was running AAS and sarms together and he knows for a FACT that his AAS didn't do anything for him but the sarms transformed his life. lmao!
So needless to say, my desire for some entertainment turned into frustration and I feel bad for those falling for their crap.
fodsod
Well-known Member
I did a combo of IGF-1 L3 (50mcg-100mcg) with MK-677 (30mgs) every night prior to bed. I did hold water in the muscles (fuller even though I was on 60-70 grams of carbs daily) and got some really, really good pumps. One of them made me hungry as hell for about a week. Can't say I saw much other than that. I was taking a break from HGH at the time and only ran them for about a month.
I was running tren A at 125mg ED, sust @ 1200mg /week and 50 mg of Adol ED combined with Albuterol, and T3 also. So maybe if I was only doing a cruise I'd got more from it.
I was running tren A at 125mg ED, sust @ 1200mg /week and 50 mg of Adol ED combined with Albuterol, and T3 also. So maybe if I was only doing a cruise I'd got more from it.
SARMS can be GREAT! but they are not without sides, and it IS STILL playing with your hormones so dont kid yourself just because it might not b classed as a steroid.
they are a great alternative to typical oral AAS use in kicking off a cycle and are a great addition to cycles over all (depending on SARM)
BUT most reps DO over hype then while minimizing the possible sides. like shutdown, liver toxicity and/or screwy blood results...
i only voted no because you said in regards to what reps say. but they are great compounds.
they are a great alternative to typical oral AAS use in kicking off a cycle and are a great addition to cycles over all (depending on SARM)
BUT most reps DO over hype then while minimizing the possible sides. like shutdown, liver toxicity and/or screwy blood results...
i only voted no because you said in regards to what reps say. but they are great compounds.
if you used this without a test base then thats mistake #1...
ofcourse they will shut you down, some more than others (thus far)
GoldenJ77
New Member
SARMS are extremely sketchy in my opinion and research. These are not miracle muscle builders. Effects, if any, are small and more of a placebo effect than anything. Remember pro hormones? Yeah 2x the side effects, 1/3 the results of real steroids. Ever heard of test boosters? Yeah fuck all this bullshit. These are another easy dollar for supplement companies. I would stay completely away. Like super far away.
BuckEighty
New Member
Idk much about sarms, but I'd rather stick to the tried and true drugs (AAS).
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