Lopez DS, Qiu X, Advani S, et al. Double Trouble: co-occurrence of testosterone deficiency and body fatness associated with all-cause mortality in US men. Clinical Endocrinology. Double Trouble: co‐occurrence of testosterone deficiency and body fatness associated with all‐cause mortality in US men
Background: Testosterone deficiency (TD, total testosterone ≤ 350 ng/dL [12.15 nmol/L]) and obesity epidemic are growing in parallel in the United States. Yet the sequelae of TD and obesity on the risk of mortality remains unclear.
Objective: To investigate whether the co-occurrence of TD and overall obesity (body mass index ≥ 30 kg/m2), and abdominal obesity (waist circumference ≥ 102 cm), is associated with a risk of all-cause mortality in American men.
Design: The data were obtained from the NHANES 1999-2004 and the Linked Mortality File (December 31, 2011). A total of 948 participants aged ≥ 20 years old with endogenous sex hormones and adiposity measurements data were included in this study.
Results: Over a median of 9.5 y of follow-up, 142 men died of any cause in this cohort. Multivariable analysis showed a 2.60 fold increased risk of death among men with TD compared with men without TD (Hazard Ratio
= 2.60; 95% confidence interval [CI] = 1.20 – 5.80). No evidence for interaction between TD and overall or abdominal obesity with risk of death (Pinteraction ≥ 0.80). However, only after comparing men with TD and abdominal obesity with men without TD and no abdominal obesity, we found a 3.30 fold increased risk of death (HR = 3.30, 95% CI = 1.21 – 8.71).
Conclusion: Men with co-occurrence of TD and abdominal obesity have a higher risk of mortality. The effect of co-occurrence of TD and abdominal obesity should be further explored with a larger and longer follow-up time study.
Background: Testosterone deficiency (TD, total testosterone ≤ 350 ng/dL [12.15 nmol/L]) and obesity epidemic are growing in parallel in the United States. Yet the sequelae of TD and obesity on the risk of mortality remains unclear.
Objective: To investigate whether the co-occurrence of TD and overall obesity (body mass index ≥ 30 kg/m2), and abdominal obesity (waist circumference ≥ 102 cm), is associated with a risk of all-cause mortality in American men.
Design: The data were obtained from the NHANES 1999-2004 and the Linked Mortality File (December 31, 2011). A total of 948 participants aged ≥ 20 years old with endogenous sex hormones and adiposity measurements data were included in this study.
Results: Over a median of 9.5 y of follow-up, 142 men died of any cause in this cohort. Multivariable analysis showed a 2.60 fold increased risk of death among men with TD compared with men without TD (Hazard Ratio
= 2.60; 95% confidence interval [CI] = 1.20 – 5.80). No evidence for interaction between TD and overall or abdominal obesity with risk of death (Pinteraction ≥ 0.80). However, only after comparing men with TD and abdominal obesity with men without TD and no abdominal obesity, we found a 3.30 fold increased risk of death (HR = 3.30, 95% CI = 1.21 – 8.71).
Conclusion: Men with co-occurrence of TD and abdominal obesity have a higher risk of mortality. The effect of co-occurrence of TD and abdominal obesity should be further explored with a larger and longer follow-up time study.
