2,4-DiNitroPhenol [DNP]

Heretic

New Member
Credit to the gods that wrote this... :)

HOW TO NOT FUCK UP DNP:

Since some guys have been playing around and disrespecting DNP and then griping to the forums about the painful results, we need to make this VERY specific and VERY correct so that people won't keep jumping for DNP out of curiosity, or without the willpower they need to operate this respondibly. So here are my experienced guidelines to using it the RIGHT way.

FIRST GUIDLINE: Dosing. Use ONLY 200mg a day for the first four days. I don't care that you don't "feel" anything yet and you wanna bump it up. DNP accumulates in the body, and not "feeling" something means NOTHING. It's there, and it's working (the effect on metabolism begins within two hours of the first dose!). Four days will let you test your tolerance: do you have an allergy? Does it give you a rash? etc.
Only after those four days do you bump it up, by 200mg a day. The average dose is 400-600/day, and more than that gets a little severe. A full gram is the highest dose I've heard anyone use. I've used that much, and it's hell. I like to stay around 600 a day, which is HOT but safe and effective. Take caps even hours apart through the day, ending about 4-5 PM.

SECOND GUIDLINE...How to eat on DNP. This is purely personal experience, because some guys like to carb-deplete *before* using DNP (then eat carbs as usual while on), and other guys like a low-carb approach throughout. Both are fine. Using DNP is the only time that fructose is a desireable cutting carb, because it keeps the liver replentished. That reduces lethargy and spares muscle.
Be aware that eating high-carb foods WILL increase the heat sensation within an hour, and last about 2 hours. That means don't eat carbs before bed unless you want those night sweats to be even WORSE.
Personally, I ate whatever the hell I wanted! IHOP, chinese, fajitas...Yes, I burned hot, but I still lost 1.5 pounds every 2 days. Keep protein HIGH for muscles' sake, and try it yourself.

Foods I suggest including:
Blueberry yogurt. Blueberries are excellent antioxidants, and yogurt cultures help with digestive function, gas, and stool consistency (disgustingly soft stools are common during DNP).
Oregano-based foods. Oregano is perhaps one of the most potent antioxidants around,a nd one spoonful counts as a vegetable serving. See this article
Pineapple - I've found that pineapple helps alleviate those "DNP Blues". The fructose helps, and pineapple enzymes aid in protein digestion.
V8 - one 12-ounce can supplies six servings of veggies, concentrated as an excellent source of antioxidants, lycopene, and recovery of electrolytes.
Oatmeal - high-fiber foods are necessary. You'll find out why around, oh, day 5 or so. Trust me.


THIRD GUIDELINE...Supplements and DNP. I suggest:
ECA - DNP is not a stimulant. To keep energy high and aid in fat loss, use an ECA. Some advisors suggest that regular ephedrine is preferable to norephedrine because of the more direct "hit" of energy.
Prohormones - perfectly fine on DNP. I used 1-AD just to help keep strength and muscle up, and it worked fine. No problems here. You won't GROW muscle on DNP, but it'll help with strength and protection.
Obvious stuff - multivitamin, ZMA, etc.
Biotest PowerDrive - No, I'm not pimping Biotest. But PowerDrive is an excellent pre-workout mixture that actually works. Plus it's low-carb (only 15 calories total), so it won't cause carb-heat in the middle of your workout.

Antioxidants - I'm giving my own personal list, and why I use them:
Alpha Lipoic Acid - aids in fat management and blood sugar, and an excellent antioxidant.
Grape seed extract
Syntrax Radox
Green Tea
Inositol - mood enhancement, antioxidant, and muscle support. 1 gram/3x day
Ellagic acid - protects cell DNA/RNA from damage by free radicals, and may even atack cancerous cells. 400mg/twice a day
Fruit antioxidants - beyond-a-century's powder of high-potency natural fruit anti's. 1 gram, 2-3x day.
Trimethylglyceine - antioxidant, helps move fat and blood lipids into the liver and out of the body. 500mg, 2x day.
Vitamins E and C

Supplements NOT to use:
Any medications that suppress energy. No allergy meds, antidepressants, muscle relaxers, or beta blockers. DNP will have you low as it is; don't worsen your body's energy by taking something that suppresses you further.

DRUGS - Sheesh, you'd think I wouldn't have to mention this, but two idiots in particular (right here on this forum) recently affirmed that some people still just don't get it. NO alcohol (not even "moderate"), NO ecstasy, NO GHB, etc. If you don't have the willpower to forego these habits, DNP is not for you.

Syntrax Swole - a personal discovery. I tried Swole while on DNP...once. Two hours of hell, feeling inside-out.

FOURTH GUIDELINE...working out on DNP. Keep lifting short, 30-40 minutes. DNP works very well, causing your body to use 150% or more the calories per action you'd normally use. That means DON'T try to repeat your usual workouts. Drop to moderate weights, 8-12 reps, not to failure, and with plenty of walking rest between sets. You are NOT going to grow muscle on DNP, so don't use your usual heavy routine. Since DNP can cause light-headedness and heat dizzyness, you have my permission to skip squats in favor of leg presses this time.

Cardio is a controversial one. My advice - do NOT do cardio on high doses of DNP (600mg or more). It's dangerous and counterproductive. Below that amount, some cardio is fine, but keep it to 20 minutes and not at full-gallop. Remember, DNP will drain water from your quickly, causing you to leech out minerals, vitamins, and salts. Don't overdo it.

During exercise, consume at least 1 liter of water per 30 minutes of work, whether you're thirsty or not. DNP is evil in the way it blunts thirst, while at the same time doing the cruel trick of bloating your body with water WHILE dehydrating you from water in your organs. MAKE yourself drink. Always folllow DNP exercise with antioxidants, carbs, and this is a good time to use your multivitamin.

Don't feel embarrassed about poor workouts. Just this morjning I did a workout with a whopping nine sets (wimp!) before calling it quits. Listen to your body, and let it tell you when enough's enough; don't guage workouts by what you *usually* can do otherwise.

Here's my research. This is AMAZING! Not only has not a single test found it to be carcinogenic, but test after tyest after test find that DNP actually ATTACKS cancer cells, and helps anti-cancer medications work better, and helps anti-leukemia medications work without destroying cell DNA, and suppresses tumor growth by 20-50%. The summaries are all right here, friends. Karma me up!

DNP is Ames negative, and does not promote tumors. See for yourself at http://toxnet.nlm.nih.gov/

http://www.epa.gov/ttn/atw/hlthef/dinitrop.html (2,4-Dinitrophenol | Technology Transfer Network Air Toxics Web site | US EPA) reports on health risks. While there have not been human studies, animal studies found no cancers caused by DNP administration. It is considered a toxin because it causes nausea, sweating, and weight loss.

Cyberiron.com reports on halth risks from external exposue. In other words, don?t get it in your eyes, or on your skin if you?re allergic. Pretty elementary stuff.

http://www.ebec2000.com/abstracts/056.htm This animal study documents a 64% increase in metabolism. "These findings confirm that DNP effectively increases metabolic rate..." Duh.

Biosource A PDF file about an antidote to DNP.

http://www.boehringer-ingelheim.es/...glesa/cap13.htm finds that DNP did not activate liver enzymes (MAT) associated with liver damage

"Comparative study of toxicity of 4-nitrophenol and 2,4-dinitrophenol in newborn and young rats." Koizumi M, Yamamoto Y, Ito Y, Takano M, Enami T, Kamata E, Hasegawa R. Division of Risk Assessment, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. This study found that DNP can induce death in overdosed amounts, but that up to that point no toxicity was evident, nor were there any abnormalities in physical development.

"Phenol toxicity and conjugation in human colonic epithelial cells." Pedersen G, Brynskov J, Saermark T. Dept of Medical Gastroenterology, Herlev University Hospital, Copenhagen, Denmark.. This study found that DNP has a toxic effect on cells of the colon, with "toxic" defined in two ways: first, it interfered with metabolism (this we know?it?s the intended effect of DNP users!) and second, it interfered with bowel inflammation (not a health risk. This is caused by osmotic effect, with the worst results being softened stools and gas).

"Mechanisms of bacterial resistance to macrolide antibiotics." Nakajima Y. Division of Microbiology, Hokkaido College of Pharmacy, 7-1 Katsuraoka-cho, Otaru, Hokkaido 047-0264, Japan. This study found that antibiotic-resistant bacteria could be thwarted with DNP. "the extent of the accumulated drug in a resistant cell increases as much as that in a susceptible cell in the presence of an uncoupling agent such as?2,4-dinitrophenol (DNP)."

"Absence of Crabtree effect in human melanoma cells adapted to growth at low pH: reversal by respiratory inhibitors." Burd R, Wachsberger PR, Biaglow JE, Wahl ML, Lee I, Leeper DB. Departments of Radiation Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Check this out?DNP actually helps make melanoma tumors easier to attack by increasing ratio of oxygen consumption to lactic acid production, while glycolysis remains the same. "Therefore, tumor acute acidification and oxygenation can be achieved by exposure?"


"New insights in the cellular processing of platinum antitumor compounds, using fluorophore-labeled platinum complexes and digital fluorescence microscopy."
Molenaar C, Teuben JM, Heetebrij RJ, Tanke HJ, Reedijk J. Department of Molecular Cell Biology, Leiden University Medical Centre, The Netherlands. DNP is used as a control in tests of antitumor cells because it does NOT bind to cell DNA, nor promote tumors, yet its staining abilities enable tracking of the uptake of antitumor drugs.

Specific inhibition of breast cancer cells by antisense poly-DNP-oligoribonucleotides and targeted apoptosis." Ru K, Taub ML, Wang JH. Department of Biochemistry, State University of New York, Buffalo 14260-3000, USA Are you ready for this? DNP actually INHIBITS (!!!) breast cancers! Yes, not only does it NOT promote cancers, it?s being recognized as a cancer-fighter/blocker. "Two membrane-permeable and RNase-resistant antisense poly-2'-O-(2,4-dinitrophenyl)-oligoribonucleotides (poly-DNP-RNAs) have been synthesized as inhibitors of human breast cancer?fluorescence assay indicates that the targeted antisense inhibition by poly-DNP-RNAs leads to apoptosis of SK-Br-3 cells but does not affect nontumorigenic MCF-10A cells. The control poly-DNP-RNAs with random or sense nucleotide sequence are completely inactive." Plain English? DNP can be synthesized as an anti-cancer compound, because tests show that it blocks mutagens but does NOT affect non-mutagenic (healthy) cells, and has no RNA effects on them.

"Heat shock protein induction by certain chemical stressors is correlated with their cytotoxicity, lipophilicity and protein-denaturing capacity." Neuhaus-Steinmetz U, Rensing L. Institute of Cell Biology, Biochemistry and Biotechnology, NW II University of Bremen, Germany. The thermic effect of DNP induces protein synthesis (heat shock protein, or HSP, synthesis). In fact, it?s quite GOOD at it: "ASA, DNP and CCCP induced HSP at lower concentrations than substances with a similar lipophilicity?"

"Comparative effects of the metabolic inhibitors 2,4-dinitrophenol and iodoacetate on mouse neuroblastoma cells in vitro." Andres MI, Repetto G, Sanz P, Repetto M.
National Institute of Toxicology, Seville, Spain. In this study, DNP?s observed effect was an increase in metabolism (duh!), while the other toxins compared to it had harmful in vitro effects but no increase in metabolism.

"Inhibition of uncoupled respiration in tumor cells. A possible role of mitochondrial Ca2+ efflux." Gabai VL.Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk. DNP not only does not cause tumors, but it inhibited their respiration by 20-25% compared to controls.

"Amsacrine-induced lesions in DNA and their modulation by novobiocin and 2,4-dinitrophenol." Shibuya ML, Buddenbaum WE, Don AL, Utsumi H, Suciu D, Kosaka T, Elkind MM. Department of Radiology and Radiation Biology, Colorado State University, Fort Collins 80523. In this study, researchers found that DNP abrogates?or disrupts?cytotoxicity in hamsters (using cancerous cells). They expected to find that DNP would interfere with anticancer treatments, but instead found that DNP increased their effects. They state, though, that they cannot claim a proven effect of DNP on anticancer treatments yet, although they do agree that treatment with DNP actually enhanced the effects of the DNA regenerative therapy of anticancer chemotherapy.

"Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note." Kaufmann SH. Oncology Center, Johns Hopkins Hospital, Baltimore, Maryland 21205. The authors warn that certain anti-leukemia drugs resulted in "extensive DNA degradation." BUT (good ol? DNP to the rescue!), "Preincubation with dinitrophenol abolished the effect?"

"[Dependence of the nature of the action of metabolic inhibitors on ribosomal RNA synthesis in Ehrlich ascites carcinoma cells on cell integrity]" [Article in Russian] Akhlynina TV, Buzhurina IM, Panov MA, Rozovskaia IA, Chernaia NG. DNP actually inhibits the synthesis of RNA in carcinoma cells. In other words, it helps cancerous cells commit suicide by neutering themselves. "Ribosomal RNA (rRNA) synthesis in the intact Ehrlich ascite carcinoma cells is selectively inhibited by papaverin (ED50 = 0.01 mM), 2,4-dinitrophenol (DPN; ED50 = 5 microM), and actinomycin D (ED50 = 0.1 microgram/ml)."

"Autocatabolism of surface macromolecules shed by human melanoma cells." Bystryn JC, Perlstein J. Cancer Res 1982 Jun;42(6):2232-7. This study finds that DNP helps melanoma cells die (autocatabolize) while other cells are unaffected.

http://www.geocities.com/byggdegstor/dnpforside - tons of research, including medical studies. Excerpts:

DNP does not cause liver damage: "Their analyses demonstrate, beyond a doubt, that the liver does not suffer any damage in the course of dinitro treatment." (Biological Study of Dinitro Drugs in Humans By Dr. Jacques Bell. Bell, Jacques. 1939. Etude biologique des produits dinitres chez l'homme. Medecine. 19:749-54. Translation ? 1996 Robert Ames)

Also: "Experimental studies on animals do not show toxic effects of dinitrophenol on the kidney. Anatomical-pathological examinations of animals, even those which died from a massive dose of dinitrophenol, do not reveal any important anatomical changes, except a small degree of cytolysis. Clinical documents are not abundant, but, on the whole, do not seem to demonstrate that dinitrophenol is toxic for the kidneys."

"Dinitrophenol has almost no action on the blood cholesterol. (Grant and Schube)."

"it doesn't seem that dinitrophenol at usual clinical doses is likely to harm the kidneys."

"Dinitrophenol is remarkable for its absence of effect on the cardio-vascular system...dinitrophenol is absolutely devoid of toxicity for the heart."

"Dinitrophenol does not attack cell tissue albumin and does not determine the fat loss to the expense of the muscles, contrary to thyroxine."

"dinitrophenol offers this precious advantage that the cessation of its use at the slightest appearance of signs indicating an imminence of intoxication results immediately in the arrest of those symptoms." (Professor Pouchet)."


Interestingly, one medical theory on a health ADVANTAGE of DNP is that the slight increase in thermogenic temperature simulates the fever a body induces during a viral attack. The body increases itsheat to protect organs but kill viruses, and some theorize that DNP can do the same thing, thus killing viruses in the body. In this mechanism, DNP may have an immune-enhancing effect.
 
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Peace Division said:

Well, I've recently become interested in DNP again. I did however just find this on the internet:

(http://www.cyberiron.com/drugs/dinitrophenol.html)

Dinitrophenol (2,4-Dinitrophenol, DNP)
NOTHING IN THE TEXT ABOVE SHOULD BE CONSTRUED AS ENCOURAGEMENT TO TAKE PRESCRIPTION MEDICATION WITHOUT SUPERVISION. CONSULT YOUR DOCTOR.

Common Name: 2,4-Dinitrophenol
CAS Number: 51-28-5
DOT Number: UN 1320
Date: July, 1989
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HAZARD SUMMARY


2,4-Dinitrophenol can effect you when breathed in and by passing through your skin.
2,4-Dinitrophenol can cause reproductive damage. Handle with extreme caution.
2,4-Dinitrophenol is a FLAMMABLE LIQUID and a FIRE HAZARD.
Contact can irritate the skin. Long term exposure may cause dermatitis.
2,4-Dinitrophenol can irritate the eyes, and may cause clouding of the eye lenses (cataracts).
Breathing 2,4-Dinitrophenol can irritate the nose and throat.
High or repeated exposure can affect the nervous system causing nausea, vomiting, abdominal pain, convulsions and even death.
2,4-Dinitrophenol may damage the liver and kidneys.
IDENTIFICATION
2,4-Dinitrophenol is a yellow crystalline (sand-like) solid but is often found in a solution. It is used in dyes, photo developers, explosives, and as a preservative of lumber.
REASON FOR CITATION


2,4-Dinitrophenol is on the Hazardous Substance List because it is cited by EPA and DOT.
HOW TO DETERMINE IF YOU ARE BEING EXPOSED

Exposure to hazardous substances should be routinely evaluated. This may include collecting personal and area air samples. You can obtain copies of sampling results from your employer. You have a legal right to this information under OSHA 1910.20.
If you think you are experiencing any work-related health problems, see a doctor trained to recognize occupational diseases. Take this Fact Sheet with you.
WORKPLACE EXPOSURE LIMITS
No occupational exposure limits have been established for 2,4- Dinitrophenol. This does not mean that this substance is not harmful. Safe work practices should always be followed.
It should be recognized that 2,4-Dinitrophenol can be absorbed through your skin, thereby increasing your exposure.


2,4-Dinitrophenol may be a teratogen in humans. All contact with this chemical should be reduced to the lowest possible level.
WAYS OF REDUCING EXPOSURE

Where possible, enclose operations and use local exhaust ventilation at the site of chemical release. If local exhaust ventilation or enclosure is not used, respirators should be worn.
Post hazard and warning information in the work area. In addition, as part of an ongoing education and training effort, communicate all information on the health and safety hazards of 2,4-Dinitrophenol to potentially exposed workers.
Wear protective work clothing.
Wash thoroughly immediately after exposure to 2,4- Dinitrophenol and at the end of the workshift.
This Fact Sheet is a summary source of information of all potential and most severe health hazards that may result from exposure. Duration of exposure, concentration of the substance and other factors will affect your susceptibility to any of the potential effects described below.


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HEALTH HAZARD INFORMATION

Acute Health Effects
The following acute (short-term) health effects may occur immediately or shortly after exposure to 2,4-Dinitrophenol:


2,4-Dinitrophenol can irritate the skin and eyes.
Breathing 2,4-Dinitrophenol can irritate the nose and throat.
Exposure to 2,4-Dinitrophenol cause fatigue, thirst, sweating, headache and weakness. It may also cause anxiety and excitement.
Chronic Health Effects
The following chronic (long-term) health effects can occur at some time after exposure to 2,4-Dinitrophenol and can last for months or years:
Cancer Hazard


2,4-Dinitrophenol may cause mutations (genetic changes) in living cells. Whether or not it poses a cancer or reproductive hazard needs further study.
2,4-Dinitrophenol has not been tested for its ability to cause cancer in animals.
Reproductive Hazard

2,4-Dinitrophenol may damage the developing fetus.
2,4-Dinitrophenol has not been tested for its ability to adversely affect reproduction.
Other Long-Term Effects

Exposure to 2,4-Dinitrophenol can cause dermatitis. Clouding of the eye lenses (cataracts) may occur after a long exposure.
High or repeated exposure can effect the nervous system causing nausea, vomiting, diarrhea, abdominal pain, headache, anxiety, weakness, convulsions and even death.
2,4-Dinitrophenol may damage the liver and kidneys.
MEDICAL
Medical Testing
If symptoms develop or overexposure is suspected, the following may be useful:


Liver and kidney function tests.
Exam of the eyes.
Evaluation by a qualified allergist, including careful exposure history and special testing, may help diagnose skin allergy.
Any evaluation should include a careful history of past and present symptoms with an exam. Medical tests that look for damage already done are not a substitute for controlling exposure.
Request copies of your medical testing. You have a legal right to this information under OSHA 1910.20.

WORKPLACE CONTROLS AND PRACTICES
Unless a less toxic chemical can be substituted for a hazardous substance, ENGINEERING CONTROLS are the most effective way of reducing exposure. The best protection is to enclose operations and/or provide local exhaust ventilation at the site of chemical release. Isolating operations can also reduce exposure. Using respirators or protective equipment is less effective than the controls mentioned above, but is sometimes necessary.

In evaluating the controls present in your workplace, consider: (1) how hazardous the substance is, (2) how much of the substance is released into the workplace and (3) whether harmful skin or eye contact could occur. Special controls should be in place for highly toxic chemicals or when significant skin, eye, or breathing exposures are possible.

In addition, the following control are recommended:


Where possible, automatically transfer 2,4-Dinitrophenol from drums or other storage containers to process containers.
Before entering a confined space where 2,4-Dinitrophenol may be present, check to make sure that an explosive concentration does not exist.
Good WORK PRACTICES can help to reduce hazardous exposures. The following work practices are recommended:

Workers whose clothing has been contaminated by 2,4- Dinitrophenol should change into clean clothing promptly.
Contaminated work clothes should be laundered by individuals who have been informed of the hazards of exposure to 2,4- Dinitrophenol.
Eye wash fountains should be provided in the immediate work area for emergency use.
If there is the possibility of skin exposure, emergency shower facilities should be provided.
On skin contact with 2,4-Dinitrophenol, immediately wash or shower to remove the chemical. At the end of the workshift, wash any areas of the body that may have contacted 2,4- Dinitrophenol, whether or not known skin contact has occurred.
Do not eat, smoke, or drink where 2,4-Dinitrophenol is handled, processed, or stored, since the chemical can be swallowed. Wash hands carefully before eating or smoking.
For dust powder use a vacuum or a wet method to reduce dust during clean-up. DO NOT DRY SWEEP.
PERSONAL PROTECTIVE EQUIPMENT
WORKPLACE CONTROLS ARE BETTER THAN PERSONAL PROTECTIVE EQUIPMENT. However, for some jobs (such as outside work, confined space entry, jobs done only once in a while, or jobs done while workplace controls are being installed), personal protective equipment may be appropriate.
The following recommendations are only guidelines and may not apply to every situation.

Clothing


Avoid skin contact with 2,4-Dinitrophenol. Wear protective gloves and clothing. Safety equipment suppliers/manufacturers can provide recommendations on the most protective glove/clothing material for your operation.
All protective clothing (suites, gloves, footwear, headgear) should be clean, available each day, and put on before work.
Eye Protection

Wear splash-proof chemical goggles and face shield when working with liquid, unless full facepiece respiratory protection is worn.
Wear dust-proof goggles and face shield when working with powders or dust, unless full facepiece respiratory protection is worn.
Respiratory Protection
IMPROPER USE OF RESPIRATORS IS DANGEROUS.
Such equipment should only be used if the employer has a written program that takes into account workplace conditions, requirements for worker training, respirator fit testing and medical exams, as described in OSHA 1910.134.

Engineering controls must be effective to ensure that exposure to 2,4-Dinitrophenol does not occur.
Where the potential exists for exposure to 2,4-Dinitrophenol, use a MSHA/NIOSH approved supplied-air respirator with a full facepiece operated in the positive pressure mode or with a full facepiece, hood, or helmet in the continuous flow mode, or use a MSHA/NIOSH approved self-contained breathing apparatus with a full facepiece operated in pressure-demand or other positive pressure mode.
Common Name: 2,4-Dinitrophenol
DOT Number: UN 1599 (Dinitrophenol solution); UN 0076 (Dry or
wetted with less than 15% water); UN 1320
(Dinitrophenol, wet with at least 15% water) DOT
Emergency Guide codes: 57,36,46
CAS Number: 51-28-5
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Hazard rating NJDOH NFPA
Flammability 3 Not Rated
Reactivity 0 Not Rated
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FLAMMABLE
POISONOUS GASES ARE PRODUCED IN FIRE CONTAINERS MAY EXPLODE IN FIRE
SOLID DINITROPHENOL MAY EXPLODE
--------------------------------------
Hazard Rating Key: 0=minimal; 1=slight; 2=moderate; 3=serious;
4=severe

FIRE HAZARDS

Dried out material may explode.
Vapor explosion hazard indoors, outdoors and in sewers.
2,4-Dinitrophenol is a FLAMMABLE LIQUID (depending upon carrier solvent) or an explosive solid.
Flood with water, if water is not available ,use dry chemical or dirt.
POISONOUS GASES ARE PRODUCED IN FIRE, including Nitrogen Oxides.
CONTAINERS MAY EXPLODE IN FIRE.
FIRE MAY RESTART AFTER IT HAS BEEN EXTINGUISHED.
use water spray to keep fire-exposed containers cool.
If employees are expected to fight fires, they must be trained and equipped as stated in OSHA 1910.156.
SPILLS AND EMERGENCIES
If 2,4-Dinitrophenol is spilled or leaked, take the following steps:

Restrict persons not wearing protective equipment from area of spill or leak until clean-up is complete.
Remove all ignition sources.
Ventilate area after clean-up is complete.
Collect powdered material in the most convenient and safe manner and deposit in sealed containers.
Keep 2,4-Dinitrophenol out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the build-up of explosive concentrations.
It may be necessary to contain and dispose of 2,4- Dinitrophenol as a HAZARDOUS WASTE. Contact your Department of Environmental Protection (DEP) or your regional office of the federal Environmental Protection Agency (EPA) for specific recommendations.
=========================================
FOR LARGE SPILLS AND FIRES call your fire department immediately.
=========================================
HANDLING AND STORAGE

Prior to working with 2,4-Dinitrophenol you should be trained on its proper handling and storage.
Keep 2,4-Dinitrophenol wet or treat it as an explosive. Dried out material may explode if exposed to heat, flame or shock.
Store in tightly closed containers in a cool, well-ventilated area away from LIGHT.
2,4-Dinitrophenol is incompatible with STRONG OXIDIZERS (such as CHLORINE, BROMINE and FLUORINE, STRONG BASES, ACID CHLORIDES and ACID ANHYDRIDES).
FIRST AID
Eye Contact


Immediately flush with large amounts of water for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention (immediately).
Skin Contact

Quickly remove contaminated clothing. Immediately wash contaminated skin with large amounts of (soap and) water.
Breathing

Remove the person from exposure.
Begin rescue breathing if breathing has stopped and CPR if heart action has stopped.
Transfer promptly to a medical facility.
PHYSICAL DATA
Flash Point: Not Found
Water Solubility: Slightly soluble

OTHER COMMONLY USED NAMES

Chemical Name: 1-Hydroxy-2,4-Dinitrobenzene

Other Names and Formulations:
Alpha Dinitrophenol; Aldifen; Fenoxyl Carbon N.
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Not intended to be copied and sold for commercial purposes.
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NEW JERSEY DEPARTMENT OF HEALTH
Right to Know Program
CN 368, Trenton, NJ 08625-0368
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ECOLOGICAL INFORMATION

2,4-Dinitrophenol is a yellowish crystalline solid and is the most important of the six possible dinitrophenol forms. It is used mostly as an intermediate to make dyes, photochemicals, pest control agents, wood preservatives, and explosives. It may enter the environment from industrial discharges, spills, or possibly as a breakdown product of certain pesticides containing 2,4- Dinitrophenol moieties.

ACUTE (SHORT-TERM) ECOLOGICAL EFFECTS

Acute toxic effects may include the death of animals, birds, or fish, and death or low growth rate in plants. Acute effects are seen two to four days after animals or plants come in contact with a toxic chemical substance.

2,4-Dinitrophenol has high acute toxicity to aquatic life and to birds. Insufficient data are available to evaluate or predict the short-term effects of 2,4-Dinitrophenol to plants or land animals.

CHRONIC (LONG-TERM) ECOLOGICAL EFFECTS

Chronic toxic effects may include shortened lifespan, reproductive problems, lower fertility, and changes in appearance or behavior. Chronic effects can be seen long after first exposure(s) to a toxic chemical.

2,4-Dinitrophenol has moderate chronic toxicity to aquatic life. Insufficient data are available to evaluate or predict the long- term effects of 2,4-Dinitrophenol to plants, birds, or land animals.

WATER SOLUBILITY

2,4-Dinitrophenol is moderately soluble in water. Concentrations of between 1 to 1,000 milligrams will mix with a liter of water.

DISTRIBUTION AND PERSISTENCE IN THE ENVIRONMENT

2,4-Dinitrophenol is slightly persistent in water, with a half-life of between 2 to 20 days. The half-life of a pollutant is the amount of time it takes for one-half of the chemical to be degraded. About 98.75% of 2,4-Dinitrophenol will eventually end up in water; about 0.65% will end up in terrestrial soil; and about 0.6% will end up in aquatic sediments.

BIOACCUMULATION IN AQUATIC ORGANISMS

Some substances increase in concentration, or bioaccumulate, in living organisms as they breathe contaminated air, drink contaminated water, or eat contaminated food. These chemicals can become concentrated in the tissues and internal organs of animals and humans.

The concentration of 2,4-Dinitrophenol found in fish tissues is expected to be somewhat higher than the average concentration of 2,4-Dinitrophenol in the water from which the fish was taken. SUPPORT DOCUMENT: AQUIRE Database, ERL-Duluth, U.S.EPA.
 
No, it's not BS, but you have to take it in context. DNP is labeled as a poison for handling and transportation purposes because it can cause nausea and sweating, which are definitions of a poison. The powder, when dried, is extremely flammable and must be specially handled and transported, another reason why it has an MSDS. Have you ever drank a beer or smoked a cigarette? Did you read the warnings on the side? Did that stop you? Hell no, because you realize that taken to an extreme both can be harmful, but used in moderation the risks are minimal.
Don't get it in your eyes, don't inject it, don't snort it, and don't go over the usual dose of 5mg/kg body weight unless you are experienced it. If you bother to read the article I posted you will see plenty of links to studies done on humans and animals showing that DNP can be used safely and effectively for fat loss in humans, and in fact that it maybe safer than clen, T-3, or ECA
 
OK, I read somewhere on here that it is advised not to be used when using anti-depressents. I am using lexapro right now and was interested in some dnp. Is this not advised because it can physically harm you or because you are so down while on dnp???
 
I've never seen any advice about not taking anti-d's while on DNP. DNP has no effect on mood, physically it makes you lethargic and tired, but it's not an upper or a downer or anything. If it helps at all I've never heard of any complaints or problems. Obviously don't drink or do rec drugs while on it, I don't think I'd even use valium or vicodin just to be safe.
Regards,
-H-
 
Heretic said:
I've never seen any advice about not taking anti-d's while on DNP. DNP has no effect on mood, physically it makes you lethargic and tired, but it's not an upper or a downer or anything. If it helps at all I've never heard of any complaints or problems. Obviously don't drink or do rec drugs while on it, I don't think I'd even use valium or vicodin just to be safe.
Regards,
-H-

I did read the stuff you posted, it's just I found the above info as well. But yeah I wouldn't let it put me off, I mean, shit, like you said, everything has risks, especially if not used properly.

BTW Heretic, I emailed you about the possibility of obtaining some DNP. Did you get my email?
 
Back up!
I've heard of people having DNP for over 6 months and still using it no problem, so I think it keeps just fine as long as it's away from light/moisture.
I can't think of any reason DNP would make you more sensitive to UV, but I would take it easy first to make sure. My main concern would be keeping an eye out for not getting too hot. I think I've tanned on it before no prob.
Regards,
-H-
 
Hi LWB, Im assuming this is lightweight from AR. Nice to see familiar names. Didnt know you were here also.

I just finished a DNP cycle. Lost 8 pounds in 10days. I started out at 200mg caps first 2 days then upped it to 400mg spreading it out one cap in the day and one at night. I bought 50 of them. Works really well. Sweat a lot and was tired but worth the experiment. Now Im trimming down a bit from the bloat and I cant wait to see how that looks.

Very informational post indeed. For others to read I wanted to share my experience with DNP so others can gain more confidence in the use if properly used without abuse.

I did much much research before I even bought the stuff and this is very important. Hate when people jump on stuff without researching the product first.

I carb depleted tapering down 3 days out before first day of DNP to get the extra advantage of the DNP (probably not necessary). I still trained but of course you are very lethargic so training was a minimal. I also took the following supps while on it.

ALA 2XED
Multi-E 2xED
Vitamin C 1gram ED
Vitamin E 1gram ED
Milk Thistle 600mg
Flax Seed Oil 1000mg 2xED
V8 juice through out the day
Cup of oatmeal and scoop of protein and peanut butter every morning.
White/Brown rice along with Chicken Breast and half cup of veggies every meal. Tapering off carbs towards the night. Of course 1 Gallon of distilled water through out the day. Took my temp consistantly to watch out. I reached up to 100 degree's and stayed there by third day.

I've seen others add more to this but this seemed ok for me. I had no problems on DNP besides sweating a lot. Kept the fan on me at night and heat down. I have air at work but its never hot there anyways.

Hope this adds to the thread. LMR
LightWeightBaby! said:
I did read the stuff you posted, it's just I found the above info as well. But yeah I wouldn't let it put me off, I mean, shit, like you said, everything has risks, especially if not used properly.

BTW Heretic, I emailed you about the possibility of obtaining some DNP. Did you get my email?
 
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has anyone tried longer (e.g. 3-6 week) cycles of low-dose DNP?

Seems like DNP always comes in 200mg capsules. Couldn't a user re-package them into (approx) 100mg doses by buying empty gel capsules and splitting the doses?

Any thoughts on this? I've heard that DNP *powder* can be really irritating to the throat, so I'm assuming you'd have to be super careful about this. Also, do people recommend having Benedryl around for the first couple doses?
 
cvguy said:
has anyone tried longer (e.g. 3-6 week) cycles of low-dose DNP?

Seems like DNP always comes in 200mg capsules. Couldn't a user re-package them into (approx) 100mg doses by buying empty gel capsules and splitting the doses?

Any thoughts on this? I've heard that DNP *powder* can be really irritating to the throat, so I'm assuming you'd have to be super careful about this. Also, do people recommend having Benedryl around for the first couple doses?

Unless you have access to a hood, I wouldn't attempt "recapsuling" to make a smaller dose. The DNP will probably get everywhere, and stain everything it touches, after a while even your hands when wearing nitriles.

It would be nice to have 100mg caps, so this way one could bump up to 300mg and not 400mg etc., etc. And I would have some Benadryl around as PL stated on the first few pages of this thread, and take it AFTER you have stopped taking the DNP. Peace.
 
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I believe Huck from EF did a 42 day low-dose DNP cycle (6 weeks), he had some real skin problems by the end of it though. DNP causes a histamine release apparently, and over time this can build up to the point of causing hives/rash, which is why you always want to take benadryl or Quercetin with it (another reason why my Generation II caps have 200mg Quercetin in them). Don't wait until you get a rash to take it, just take it anyway. It doesn't happen to most people, and not always the first cycle either, but just be careful. I've heard of people taking 1 200mg cap every 3rd day (DNP's halflife is 36-48 hours I believe) so that they keep it in their system but don't let it build up too much, but I think this is mostly used by women. It could be a way to cycle it longer though.
I am looking into making 100mg caps, problem is that the price would be the same as the 200mg caps, so I don't see why anyone would buy them. You have to undestand that the powder itself isn't very expensive, what you're paying me for are the risks I take and the BITCH that is to handle and encapsulate DNP. My risks and labor are the same whether it's 100mg or 200mg, so the price would be the same as well.
Regards,
-H-
 
was wondering if i could just stay on 200mg cycles instead of bumping up to 400mg,and still get good results, im just interested in losing fat gradually, not 20lbs in a month type of speed. anyways if im way off base let me know cuz i got some of heretics stuff on the way.
 
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