One more thing

[sade]

Ha! You only wish you had my T and LH levels! You don't have MAIS, be ready for that. Steroids don't case MAIS and you were fine before taking them.

You are one jealous 3 week dbol cycling fucker who wished you had my bloodwork. 3 weeks of dbol didn't do that to you. maybe you were born like that? Ever thought about it?

I never said steroids caused my MAIS you 3 week dbol cycling f**knugget. What I did say is that I never gained a pound of muscle from my steroid cycles which is perfectly normal isn't it 3 week dbol cycling brother? It's perfectly normal to hammer anabolic steroids in your twenties and not gain a single pound of muscle?

Unless your 3 week dbol cycling ass can think of why I didn't gain any muscle on any of my steroid cycles then I think it could have due to having a rare genetic disorder. Don't you think? 3 week dbol cycling rudeboy?

 

[idmd]

Alright I have to admit....what's the significance of Dbol and 3 weeks? Never cycled before....

 

[Effeminate_builder]

Alright I have to admit....what's the significance of Dbol and 3 weeks? Never cycled before....

Can someone plz explain me what exactly is Kennedy disease.
I know that it has got something to do with an AR mutation.
But what are its symptoms besides undervirilization ?
The wiki article makes no sense to me

 

[Effeminate_builder]

Sade why dont you give mesterelone a try.

Its affinity and disassociation Kinetics with the Androgen receptor are different from Test.
They say that Proviron does not help with muscle mass but a lot of what gymrats say is just anecdotal.
My Dad gained about 5-10 pounds when he used proviron for low sperm counts when he was trying to concieve me.

 

[Effeminate_builder]

As defects in AR causing partial androgen insen-sitivity can respond to hormonal therapy the mutant
receptor was tested with several androgens in clinical use to
identify the analog with the greatest therapeutic potential.[1]

AR was tested with the androgen analogues, mesterolone and flu-oxymesterone, and the anabolic androgen, nortestosterone.
Nortestosterone and mesterolone did not improve the trans-activation function of the mutant AR. However, nanomolar
doses of fluoxymesterone were able to restore mutant AR
function to normal levels. Our in vitro studies provide a
rational basis for selecting fluoxymesterone, if any androgen
therapy is contemplated in this patient. However, such ther-apeutic use of androgen analogs is problematical, as andro-gens administered systemically could result in excess an-drogen action elsewhere with potentially harmful effects and
through negative feedback inhibition of FSH and LH can
reduce testicular androgen and sperm production further[1]


[1] Azoospermia Associated with a Mutation in the Ligand-Binding Domain of an Androgen Receptor Displaying
Normal Ligand Binding, but Defective Trans-Activation*
QI WANG, FARID J. GHADESSY, ALAN TROUNSON, DAVID DE KRETSER,
ROB MCLACHLAN, S. C. NG, AND E. L. YONG

 

[Effeminate_builder]

All AR mutations are not the same .
The above guys AR responded to floxy yours might respond to mesterelone,mine might respond to 500mg Test.
Just saying

 

[sade]

Alright I have to admit....what's the significance of Dbol and 3 weeks? Never cycled before....

Well basically, he took dianabol 10-11 years ago and lost his dick after taking dbol for only 3 weeks. His hormones are perfect. His T is 700 ng/dl and his LH is oh so perfect at 3 IU/L. I won't say anymore because I think he's had enough.

 

[sade]

From the same study:

There are lots of folks post-AAS or propecia with normal T, E2, etc. levels suffering from hypogonadal symptoms. Seems it's some physical/mental changes leftovers that are hard to heal after body/mind was damaged by widely changing hormonal levels during/after course of drug. But it's not testosterone deficiency in common sense, all hormones may be within ranges.

Don't you ever compare my steroid cycling ass to propecia folks you dick fucker. You are one fucked up 3 week dbol cycling individual. Your bloodwork proves that dbol did no damage to you what so ever. You were born like that you fucknugget. You keep mentioning how your so called post propecia brothers have normal T levels etc etc... but the one thing your 3 week dbol cycling dick losing pussy ass forgot is that they don't have high LH. Does your 3 week dbol cycling dicklosing pussy ass even know what high LH means?

 

[hebsie]

...you drunk or just plain crazy Sade? Perhaps some of both...hebs <insert cuckoo clock gif>

 

[sade]

...you drunk or just plain crazy Sade? Perhaps some of both...hebs <insert cuckoo clock gif>

lets just say that I'm more crazy when drunk.

Mild androgen insensitivity presenting with sexual dysfunction.

A man presented with sexual dysfunction and was found to have elevated serum levels of both gonadotropins and T, suggesting AIS. Small external genitalia were the only phenotypic abnormality. Serum T levels increased appropriately in response to hCG and CC, but the patient was severely oligospermic, and testicular biopsy study revealed profoundly impaired spermatogenesis. Studied on androgen receptors in genital skin fibroblasts were normal. PAIS with a virtually normal male phenotype can present in adulthood with sexual dysfunction as well as infertility. As with the syndrome of complete AIS, androgen receptor studies indicate that this is a heterogeneous group of disorders.

Mild androgen insensitivity presenting with se... [Fertil Steril. 1986] - PubMed - NCBI

 

[sade]

Molecular studies of the androgen receptor gene were performed in 10 azoo- or oligozoospermic men, p]resenting with clinical signs of low androgen activity—poor virilization and high serum LH despite elevated testosterone levels[/B], but without genital malformations.

Ten men with serum LH >10 IU/l and testosterone >30 nmol/l as well as a low sperm concentration <?20 × 106/ml.

Two of the 10 men were shown to have a mutation in the androgen receptor gene. Subject 1, who presented with azoospermia, serum testosterone (T) 50 nmol/l and LH 20 IU/l, had a mutation in exon 1, changing amino acid asparagine 233 to lysine (N233K). In fibroblasts cultured from genital skin, the receptor affinity for 5?-dihydrotestosterone (DHT) was normal as compared to healthy controls, but the receptor–hormone complex was thermolabile at 42°C. Subject 2 exhibited severe oligozoospermia and a similar endocrine pattern (T = 50 nmol/l and LH = 25 IU/l). He had a mutation in exon 5 changing asparagine 756 to serine (N756S). The affinity for DHT in cultured genital fibroblasts from this patient was reduced. Transactivation was abnormal for both mutants, N233K reaching 46% and N756S 38% of wild type activity when stimulated with 10 nmol/l DHT.

A novel mutation (N233K) in the transactivating domain and the N756S mutation in the ligand binding domain of the androgen receptor gene are associated with male infertility* - Giwercman - 2002 - Clinical Endocrinology - Wiley Online Library

 

[sade]

Soa bottle of this came through the post this afternoon:

Anyone used it? Each pump is 100 ml and I think it's 100 mg/ml. I won't try it out till next year though because I still need to take a blood test before my endo app which isn't till next year plus I have other personal issues which no one on here knows about.

 

[sade]

been on a combo of vitamins and herbs including DHEA and Zinc. Libido is improving and today got about 6-7 spontaneous boners though not 100% but still something. I'm wondering whether it's the DHEA or Zinc. Also been waking been getting nocturnal and morning wood the past 2 weeks but again not full erections but they have been staying up for about half an hour or so.

 

[sade]

Re: Anyone run supraphysiological? Potentially counter productive

Men whose FSH or LH levels remain high on TRT can usually tolerate higher doses of T

https://docs.google.com/viewer?a=v&...c4y3LE&sig=AHIEtbRcG-ghYICoxv4ZfhlwZ4Z6t-_4JA

I guess he was on about guys with a level of 700-800. I'm not on TRT but my T is as high as men on TRT; 879, 844, 732 with an LH of 13.0, 12.8, 11.4.

CASE REPORT: This 29 year old patient had ambiguous genitalia at birth but was found to be 46 XY. He had a small, hypospadiac penis with underdeveloped bifid scrotum. There was no significant family history. After puberty he developed female secondary sexual characteristics. He responded poorly to low dose exogenous androgen and underwent multiple genital reconstructive operations. He was then lost to follow up. On representation in Aberdeen at the age of 27 years his T was 38nmol/l, FSH 3.7u/l, LH 12u/l and oestradiol 240pmol/l. He commenced Sustanon IM weekly injections, initially 250mg for 2 months and then 500mg for 2 years. He has shown significant increase in libido, development of facial and body hair and deepening of voice. His current T is 120nmol/l, FSH 1u/l, LH 3.6u/l and oestradiol 170pmol/l. Lipid profile and haematocrit have remained normal throughout.

His current T is 3458 and LH is normal at 3.6, so high dose trt in this individual didn't shut him down otherwise his LH would have dropped below 0 if it did.

 

[sade]

Re: Anyone run supraphysiological? Potentially counter productive

Play with fire long enough you will eventually get burned ..

My point is yes supraphysiological levels of T will fuck up you up if you have hypogondal T but it isn't the same for rare individuals such as myself. The only way to prove it is by experimenting myself and getting regular bloodwork. I am im however in the minority.

 

[sade]

Re: Anyone run supraphysiological? Potentially counter productive

It might not be rase as you think:

Boba155
Boba155 is offline New Member

Join Date
Jun 2012
Posts
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Mild Androgen Insensitivity Syndrome and HRT

Hi all!

So I was recently diagnosed with MAIS. Here's an abstract which explains the symptoms:

"Impaired spermatogenesis is not an obligate expression of receptor-defective androgen resistance."

Basically it's a condition where even though you produce normal or even high levels of testosterone (I was 680 TT, 15.6 Free) you express many low testosterone symptoms because your receptors respond very poorly to androgens. Growing up I always looked far younger than my age, carried no muscle mass on my body whatsoever (6'2 130 lbs), grew male hair only on my legs and arms (no chest or facial hair) and more, such as a very weak jaw, narrow shoulders, and a high voice.

Surely enough, my doc raised the possibility of MAIS to me when he saw how concerned I was with my masculinity, or rather lack thereof. Surely enough, we performed the genetic testing using a fibroblast sample from me and the test came up red: an extremely reduced affinity for T and DHT.

My doc and I, while both ecstatic that we had isolated the root of all my problems over the last 18 years, were slightly saddened as the only way to truely treat MAIS is with high dose TRT.

So after biting the bullet, I decided to go on high dose TRT (500 mg/wk). Now I understand many of you may think this is a crazy dosage, but please understand that I am a rather unique case.

Here is my question to you all. Is there any way I can use 500 mg Test E for the rest of my life healthily? I am worried about cholesterol and BP, along with heart problems from running such a high dose for so long.

My second question would be the issue of TRT itself. I'm only 18 years old, which means that I would have a VERY long TRT life ahead of me. I would be on shots for the next 65-70 years, which I'm sure to most would be disconcerting. To me, it certainly is. Could anyone who has gone on TRT at a young age as myself possibly PM me their TRT experience? It would mean the world to me!

Thanks all!

Mild Androgen Insensitivity Syndrome and HRT

 

[sade]

i fucj=king hate posting here. I can't even start a new thread anymore without my fucking post being moved here. wtf. im not coming back here. WHY DO YOU DO THIS TO ME.

dR SCALLY COULD TAKE THE FACT THAT I POSTED THAT NEBIDO TEST UNDECANOATE POST WHERE STRUCTURE RIPPED HIM AND HE COULDN'T TAKE IT AND DELETED IT.

 

[Michael Scally MD]

My doc took a culture of fibroblasts (a cell type with a large androgen receptor population) and then incubated them with DHT and testosterone , along with other androgens, along with a tracer. He then measured the level of AR gene transcription and found it to be VERY low, indicating a very weak affinity for androgens (insensitivity). He performed the test a few time to account for error.

I'll see if I can find the exact protocol for ya.

Mild Androgen Insensitivity Syndrome and HRT

This is does not make sense! AIS is diagnosed by genetic sequencing, not a 20+ year old technique, which is inaccurate and indirect. This does not pass the smell test. Also, he complained about his muscles, but nothing else! Stay off the ETOH.

 

[sade]

gggg

fuck you you fucking pricks. stop moving my threads. ban me you fucking cunts i hate you all you fucking dickheads. ban me forever you fucking full blown dickheadd

 

[Tyler81]

been on a combo of vitamins and herbs including DHEA and Zinc. Libido is improving and today got about 6-7 spontaneous boners though not 100% but still something. I'm wondering whether it's the DHEA or Zinc. Also been waking been getting nocturnal and morning wood the past 2 weeks but again not full erections but they have been staying up for about half an hour or so.

Clearly low T is not your issue nor is TRT the solution you are seeking.