yellow eyes on dnp.

[res]

i have had two people come up to me at work and say that my eyes and skin were yellow. said it looked like i had jaundice. anyone know if that is normal?

 

[demeurj]

wow this thread got interesting while i was away

some questions i would like to pose are as follows:

1) given that DNP finds its way into ocular secretions, is it not reasonable to postulate that the sclera of the eye, or the conjunctiva has had some of the drug distributed into them, either intra or extracellularly?

It's a reasonable postulate but those often lead us astray in medicine. The cornea and sclera are largely nourished by simple diffusion (that's the primary reason you should not wear most contacts for more than a few days). There's enough musings to think DNP may cause cataracts. But whether that's DNP in secretions diffusing into the eye or DNP in the bloodstream . . . no one knows. But remember cataracts are opacification of the lens NOT the cornea.

2) given taht there are so many people willing to use DNP, is it not a reasonable idea to jsut get one of those persons exhibiting yellowing of the eyes to get a bilirubin level done and to end this?

You wouldn't want a bili alone. You would actually want a liver panel (AST, ALT, AlkPhos, GGT, PT, direct and total-bili) and if the HMO is paying toss in some albumin, total protein, lactic acid dehydrogenase, and creatine kinase just for curiosity's sake since we are tinkering with energy metabolism.

3) is it safe to assume that any elevation in bilirubin is actually a manifestation of a compromised liver, and not in fact an increased level of bilirubin due to another aspect of bilirubin elimination?

nope . . . elevated bilirubin could be excess production and/or inadequate clearance. Gall bladder obstruction (such as simple stones) may raise your bili to a greater extent than typical drug-induced cases such as opiates, aspirin, diuretics, oral contraceptives, and even AAS. On the other side of the ledger, caffeine, high dose aspirin, and barbituates lower bili. In essence, you could easily have an acute change in bilirubin without a substantive change in liver function. But if you are a heavy drinker (cirrhosis) or hooked up with Pam Anderson (Hepatitis C) . . . then yeah you messed up your liver. If you are fat, female, and 40 . . . those are stones.

4) in those individuals who exhibit yellowing of the eyes, when does it occur, and how long does it last? the reason i ask this is that i know someone who has used this drug and has had yellowed eyes, and he said that they were transient, lasted only a few hours, and were usually in the morning or after long stints in front of a computer- leading me to believe that it was likely a deposition of DNP on the sclera through ocular secretions and drying, rather than any elevation in bilirubin

Reasonable hypothesis . . .

i do not discount the toxicity of this drug, although i would think that its administration to more than 40000 people intraveinously in the 1980s by a doctor in america with a russian last name with no report of increased liver toxicity associated illenss/syndromes does seem to downplay the severity of any reactions to the drug.

As a good pharmacist you know it's often a matter of dosage and timing. Seldane and two glasses of grapefruit juice killed a 29yo man while he mowed the lawn. Seldane is a good allergy medication but it was removed from the market in 1997 due to drug interactions which could lead to fatal heart rhythms.

oh im a pharmacist by the way, this is an intersting discussion. although i share the sentiments of previous posters about rat data. i have done a few searches in medline etc on this agent and i have never seen evidence of liver dysfunction in low doses, new or old.

Rats often point us in the right direction . . . and sometimes they totally lead us astray.

i have read a few toxicity reports on the agent and liver function was not listed as a sign of toxicity- rather it was heat, breathlessness, sweating etc etc. thats not to say that the liver is impervious to dnp caused harm, but still
anyway, ill check this thread someitme

I think one difficulty is that DNP is a poorly studied drug. It is indeed a potent agent and potentially a VERY dangerous one. It does not qualify for orphan drug status so you cannot make money off it's use (except to kill bugs and plants).

 

[DangerousG]

this pic is enough to stop me from using it

 

[IronMike]

...

this pic is enough to stop me from using it

I gave away a ton of the stuff that someone had given to me years ago. Couldn't be bothered with it and never will. For mine, bodybuilding is not a thrillskeeking pursuit of riding on the razor's edge of health.

That said, some make a valid point that at dose x a substance may have many beneficial effects, while at 2 time x it maye start to have very serious sides.

What dose were the rats given and how often (sorry if you've already written it, there WAS a lot to read there). IronMike

 

[demeurj]

this pic is enough to stop me from using it

Fair enough . . .

I've only done one cycle of AAS/PCT and despite the great gains and mild sides (pornographic daydreaming) I really don't intend to do another. After I drop a little more bodyfat I'm going to give insulin a whirl. DNP is just a little farther down the risk slippery slope. It's not radioactive iodine but it ain't table salt, either. IMHO, just like other gear DNP can be safe and effective if it is shown the proper respect.

 

[bigntasty21]

Most everyone on his thread is taking DNP wayyyyy too outta proportion. In my opinion...it's undoubtly the SAFEST fatburner that exists as of today, if used INTELLIGENTLY. First off...it doesnt increase heart rate or blood pressure like clen/ephedra could...doesnt screw with your thyroid like T3 can...no rebound coming off dnp...and if used at a moderately low dosage...you SHOULD feel fine on it and be ableto carry out normal daily activites, as long as you are in air conditioning and preferably with fans on you if possible...this is from personal experience. ive used T3...Eca stack..clen...DNP at 400mgs for me BLOWS these other fatburners away...no comparison. And you can use it indefinitely and keep getting the same results...i loose about 3 lbs a week "safely" on it...and i find 600mgs and above for me makes me very tired and bedridden..so..you just need to find what works for you (stay with a lower dose) and go from there..and start at 200mgs. Also, the yellowing of the eyes is most definately due to the yellowing dye effect dnp as..NOT liver damage...if any of you have actually done any research on dnp you would know that it does not impact the liver at low dosages...and can actually help the immune system fight off infection. Just like insulin...lasix...anadrol...or whatever...if you know how to use it intelligently, youll benefit from it without the sides....i actually swear by this stuff now...just take the proper precautions such as antioxidants...high water intake..high potassium intake...multi vit...etc...and youll be just fine. Today i saw my cum was yellow and i was like wtf lol...it's the dye from the dnp...just like the yellowing of the eyes, it just a dye. Anyways, settle down folks...unless you've used dnp before yourself you shouldnt really bash the stuff...