Differences between IGF-1 LR3 and IGF-1 DES (mention to PEG-MGF)

[Zakosa]

Hi everyone.


Since I started in the world of enhancing compounds, something that has always caught my attention above the rest are peptides, especially those that promote the increase of growth hormone and its derivatives.

To a greater or lesser extent I have learned a lot about these peptides and their types: MK-677, GHRP, GHRH, HGH Fragment... but no matter how much I research, I lack a lot of updated information (or experiences) about what are supposed to be the most potent: IGF-1 LR3 and IGF-1 DES, in addition to PEG-MGF.

Basically what I come to ask is what you can share whatever you know about these two peptides and their applications, some interesting information to know:

- What are their mechanical differences (at the level of operation)?

- What protocol is usually used?

- For what purpose are they usually used?
(I have seen growing people using IGF-1 LR3 to grow taller, is osteogenesis possible with these compounds?)

- What side effects can occur and with what severity or reversibility?

- How is PEG-MGF related to these IGF-1 variants? Is it really necessary in the first cycle?


I think that's all, any information is valuable for anyone who also has doubts.

S8L!​

 

[Type-IIx]

Hi everyone.


Since I started in the world of enhancing compounds, something that has always caught my attention above the rest are peptides, especially those that promote the increase of growth hormone and its derivatives.

To a greater or lesser extent I have learned a lot about these peptides and their types: MK-677, GHRP, GHRH, HGH Fragment... but no matter how much I research, I lack a lot of updated information (or experiences) about what are supposed to be the most potent: IGF-1 LR3 and IGF-1 DES, in addition to PEG-MGF.

Basically what I come to ask is what you can share whatever you know about these two peptides and their applications, some interesting information to know:

- What are their mechanical differences (at the level of operation)?

- What protocol is usually used?

- For what purpose are they usually used?
(I have seen growing people using IGF-1 LR3 to grow taller, is osteogenesis possible with these compounds?)

- What side effects can occur and with what severity or reversibility?

- How is PEG-MGF related to these IGF-1 variants? Is it really necessary in the first cycle?


I think that's all, any information is valuable for anyone who also has doubts.

S8L!​

This information is valuable, that's why anybody who can answer them properly gets paid to apply it.

 

[connorflex123]

Hey Type-IIx lonng time lurker I love your articles! I have seen some concerning reviews for generic IGF-lr3 I tried compounding pharmacy LR3 and it was mind blowing at the time. Do you recommend a certain source for your clients? I see QSC and others stock it

This information is valuable, that's why anybody who can answer them properly gets paid to apply it.

 

[AlexDavis43]

Super bro-science but LR3 might act more systemically whereas DES is more local to injection site. I know of no actual evidence supporting this.

I like LR3 in general. Haven't tried DES but if I did, might consider site-specific injections into lagging muscles or the muscles I'm training that day.

DES injections are thus theoretically bilateral & daily (maybe twice a day), so factor that into your daily injection burden considerations.

 

[Type-IIx]

Hey Type-IIx lonng time lurker I love your articles! I have seen some concerning reviews for generic IGF-lr3 I tried compounding pharmacy LR3 and it was mind blowing at the time. Do you recommend a certain source for your clients? I see QSC and others stock it

I cannot vouch for sources. @janoshik has shared his impressions of LR3 test results. Here ya go: How to make 0.6% acetic acid solution for IGF1 LR3 reconstitution?

 

[connorflex123]

I cannot vouch for sources. @janoshik has shared his impressions of LR3 test results. Here ya go: How to make 0.6% acetic acid solution for IGF1 LR3 reconstitution?

I guess its good old trial and error smh, an aussie source, sent me a bunk vial, caused horific water retention on holidays

 

[DugPrime]

Do you guys know if IGF-1 DES and/or PEG MGF can be taken subQ in the belly for a systemic effect?

 

[Type-IIx]

Do you guys know if IGF-1 DES and/or PEG MGF can be taken subQ in the belly for a systemic effect?

It can and it will, but MGF is a mechanosensitive local autocrine/paracrine IGF-I isoform, if it's to work at all, it'd be locally.

 

[DugPrime]

It can and it will, but MGF is a mechanosensitive local autocrine/paracrine IGF-I isoform, if it's to work at all, it'd be locally.

Some people swear by it, saying it’s crazy strong for recovery and hypertrophy, apparently working through the mitogenic and myogenic pathways. Do you think it’s actually worth trying, or is it more hype than results? And any other non-GH peptides you think are solid alternatives? LR3 and DES seem like they don’t do much for humans.

 

[Type-IIx]

Some people swear by it, saying it’s crazy strong for recovery and hypertrophy, apparently working through the mitogenic and myogenic pathways. Do you think it’s actually worth trying, or is it more hype than results? And any other peptides you think are solid alternatives? LR3 and DES seem like they don’t do much for humans.

I think they're right. What follows is that it induces muscle repair, i.e., collagen deposition (necrosis). Not muscle remodeling (hypertrophy). It'll grow the muscle's volume, but it doesn't lay down contractile tissue like AAS that stimulate myofibrillar hypertrophy.

 

[DugPrime]

I think they're right. What follows is that it induces muscle repair, i.e., collagen deposition (necrosis). Not muscle remodeling (hypertrophy). It'll grow the muscle's volume, but it doesn't lay down contractile tissue like AAS that stimulate myofibrillar hypertrophy.

If I understand correctly, it will result in useless mass? It won't provide any additional performance (strength or endurance) but will just visually appear as mass?

if it's to work at all, it'd be locally.

Doesn't the pegylated form allow it to work systematically? Since it doesn't degrade as quickly as regular MGF, it should have the time to be absorbed and circulate in your bloodstream, no?

 

[AlexDavis43]

If I understand correctly, it will result in useless mass? It won't provide any additional performance (strength or endurance) but will just visually appear as mass?

Aka muscle pump, fullness. Aesthetic, not performance.

 

[Type-IIx]

If I understand correctly, it will result in useless mass? It won't provide any additional performance (strength or endurance) but will just visually appear as mass?

It probably also appears weird, similar to the necrosis and scar tissue left behind by Synthol use.

Doesn't the pegylated form allow it to work systematically? Since it doesn't degrade as quickly as regular MGF, it should have the time to be absorbed and circulate in your bloodstream, no?

That's the theory of PEGylation, unfortunately since MGF (mIGF-IEc, in humans) is a mechanosensitive autocrine/paracrine myokine, its activity in blood/systemic is unknown, but quite likely not beneficial for hypertrophy.

 

[Type-IIx]

Aka muscle pump, fullness. Aesthetic, not performance.

Different even from sarcoplasmic hypertrophy, this is straight up scar tissue.

 

[AlexDavis43]

Different even from sarcoplasmic hypertrophy, this is straight up scar tissue.

You make it sound like a bad thing, like it will hinder future hypertrophy.

 

[Type-IIx]

You make it sound like a bad thing, like it will hinder future hypertrophy.

I think scar tissue is bad, yes. It's what occurs in aging. Can't be good, right? It causes a more brittle muscle prone to tearing, and that probably looks like shit.

Look at the graininess of guys like Dorian Yates, and dare I say, even ovmmds from CLIENT SUCCESSES: BEFORE & AFTER PICTURES

These are instances of training methods that primarily induce myofibrillar hypertrophy.

Sarcoplasmic hypertrophy, guys like cbum, and the modern ilk, mostly.

Then, look at guys like luki4744 or whatever from ProM. He's abused Synthol and PEG-MGF. His muscles look misshapen.

 

[DugPrime]

I think scar tissue is bad, yes. It's what occurs in aging. Can't be good, right? It causes a more brittle muscle prone to tearing, and that probably looks like shit.

Look at the graininess of guys like Dorian Yates, and dare I say, even ovmmds from CLIENT SUCCESSES: BEFORE & AFTER PICTURES

These are instances of training methods that primarily induce myofibrillar hypertrophy.

Sarcoplasmic hypertrophy, guys like cbum, and the modern ilk, mostly.

Then, look at guys like luki4744 or whatever from ProM. He's abused Synthol and PEG-MGF. His muscles look misshapen.

That's really crazy. But I’m really wondering if that would even affect people who train. I could totally see it being an issue for a sedentary person injecting supraphysiological doses of MGF, though.

But for us, training 5-12 hours a week and sticking to a low dose (100-300mcg) 2-3 times a week, only on workout days, I don’t think it should cause that. The guy you mentioned is probably overdoing it, especially if he’s a professional. And the synthol doesn't help tho.

You make it sound like a bad thing, like it will hinder future hypertrophy.

Yeah haha, I was actually thinking about ordering a kit to give it a try, especially since I’m not too worried about growing unusable tissue. I’m not after performance, just getting big and aesthetic. But man, I do not want to end up looking like I’m on synthol—that’d be the worst.

 

[Type-IIx]

That's really crazy. But I’m really wondering if that would even affect people who train. I could totally see it being an issue for a sedentary person injecting supraphysiological doses of MGF, though.

But for us, training 5-12 hours a week and sticking to a low dose (100-300mcg) 2-3 times a week, only on workout days, I don’t think it should cause that. The guy you mentioned is probably overdoing it, especially if he’s a professional. And the synthol doesn't help tho.


Yeah haha, I was actually thinking about ordering a kit to give it a try, especially since I’m not too worried about growing unusable tissue. I’m not after performance, just getting big and aesthetic. But man, I do not want to end up looking like I’m on synthol—that’d be the worst.

You should test it!!! I love a good uncontrolled (and unregulated) human trial!

 

[DugPrime]

TBH, if you and/or @AlexDavis43 want to shoot PEG-MGF to settle the question: whether scar tissue is good or bad for bodybuilding, please do. I love a good uncontrolled (and unregulated) human trial!

@AlexDavis43 Please, give your body to science, we need to know.

 

[AlexDavis43]

You should test it!!! I love a good uncontrolled (and unregulated) human trial!

@AlexDavis43 Please, give your body to science, we need to know.

It's cheap enough to pick up a few kits of PEG-MGF and give it a go.

Questions: once daily subQ dosing 400 ug sound in the ballpark?

Or bilateral in whatever muscles I'm training that day or lagging body parts in general? (I thought bro-science said this was how IGF1-DES was supposed to be used)