Injecting testosterone subcutaneously

[m1dpq]

Good Evening,

I wonder if anyone can help with this URGENT request???

I had my Testosterone Injection this morning (8.45am GMT 2/6/2010) but had a bad reaction to it after the needle was withdrawn from the depot-site area... I had a buring sensation from head to toe, sweating, dizziness, watering of the eyes, and running nose, overly sweating and pins & needles (tingling) all over my body.. and this is still on-going (the tingling)?

Upon coming home i have found a blood patch approx 4 inches diameter on my shorts and trousers, and this has set me wondering if the injection has entered the bloodstream en-mass rather than slow released?

Has anyone any thoughs on this? and could explain why ?

The compound is Nebido 1000mg of Testosterone in a 5ml delivery (Nebido injection contains the active ingredient testosterone undecanoate, which is an ester of the naturally occurring male hormone testosterone).

Regards

Peter
M1dpq

 

[Michael Scally MD]

Good Evening,

I wonder if anyone can help with this URGENT request???

I had my Testosterone Injection this morning (8.45am GMT 2/6/2010) but had a bad reaction to it after the needle was withdrawn from the depot-site area... I had a buring sensation from head to toe, sweating, dizziness, watering of the eyes, and running nose, overly sweating and pins & needles (tingling) all over my body.. and this is still on-going (the tingling)?

Upon coming home i have found a blood patch approx 4 inches diameter on my shorts and trousers, and this has set me wondering if the injection has entered the bloodstream en-mass rather than slow released?

Has anyone any thoughs on this? and could explain why ?

The compound is Nebido 1000mg of Testosterone in a 5ml delivery (Nebido injection contains the active ingredient testosterone undecanoate, which is an ester of the naturally occurring male hormone testosterone).

Regards

Peter
M1dpq

Where was the injection? Who did the injection? How are you feeling now? What does the injection site look like, not your clothes?

Of the common IM sites (deltoid, gluteus, vastus), there is not an easy vascular route. However, the volume could lend itself to some absorption. If there was a venous bolus, I would expect coughing or shortness of breath. I say this often - if in doubt, check it out (call the healthcare professional).

 

[m1dpq]

Injection done into Muscular area of buttock (upper left), site is marked with a red blood mark possible bruising.

Practice nurse at doctors did the injection as normal... Never had anything like this before...

At present i'm still sweating profusely, and have a bloody king sized headache, a bit woobly on my feet, and itching but that is normal...

I recieve Testosterone as i have Klinefelters syndrome and i'm also a diabetic but my sugars are 10.3 which is normal..

I did have shortness of breath and coughing after the injection, but little coughing and shortness of breath at present time.

regards

Peter
M1dpq

 

[Michael Scally MD]

Injection done into Muscular area of buttock (upper left), site is marked with a red blood mark possible bruising.

Practice nurse at doctors did the injection as normal... Never had anything like this before...

At present i'm still sweating profusely, and have a bloody king sized headache, a bit woobly on my feet, and itching but that is normal...

I recieve Testosterone as i have Klinefelters syndrome and i'm also a diabetic but my sugars are 10.3 which is normal..

I did have shortness of breath and coughing after the injection, but little coughing and shortness of breath at present time.

regards

Peter
M1dpq

I am sure the injection was not intravascular. The highest probability is a traumatic injection. But, as I said, if you are worrying this is even all the more of a reason to have the healthcare professional check it out. How many of these injections have you had? It sounds like a number.

 

[m1dpq]

Michael,

Thanks for replying.. I have had quite a few of these going every 10 weeks for blood level tests, and then 2 weeks later for the injection... so its every 12 weeks in total and this has been since July 2009, but never anything like this has happened before..

I did ring the surgery but could only speak to the Dr on call and he had no clue as he hasn't heard of it happening before and couldn't be of any help... I am going to ring the GP's surgery at 8am GMT and get an Emergency Appointment with my own GP to see if there maybe any problem, but its the total pins and needles effect this is having opon my total body and the burning sensation is still there but not as strong..

Many Thanks

regards

Peter
M1dpq

 

[heavyiron]

Subcutaneous testosterone injections

STABLE TESTOSTERONE LEVELS ACHIEVED WITH SUBCUTANEOUS TESTOSTERONE INJECTIONS

M.B. Greenspan, C.M. Chang
Division of Urology, Department of Surgery, McMaster University,
Hamilton, ON, Canada

Objectives: The preferred technique of androgen replacement has been intramuscular (IM) testosterone, but wide variations in testosterone levels are often seen. Subcutaneous (SC) testosterone injection is a novel approach; however, its physiological effects are unclear. We therefore investigated the sustainability of stable testosterone levels using SC therapy. Patients and methods: Between May and September 2005, we conducted a small pilot study involving 10 male patients with symptomatic late-onset hypogonadism.

Every patient had been stable on TE 200 mg IM for 1 year. Patients were instructed to self-inject with testosterone enanthate (TE) 100 mg SC (DELATESTRYL 200 mg/cc, Theramed Corp, Canada) into the anterior abdomen once weekly. Some patients were down-titrated to 50 mg based on their total testosterone (T) at 4 weeks.

Informed consent was obtained as SC testosterone administration is not officially approved by Health Canada. T levels were measured before and 24 hours after injection during weeks 1, 2, 3, and 4, and 96 hours after injection in week 6 and 8.

At week 12, PSA, CBC, and T levels were measured however; the week 12 data are still being collected.

Results: Prior to initiation of SC therapy, T was 19.14+3.48 nmol/l, hemoglobin 15.8+1.3 g/dl, hematocrit 0.47+0.02, and PSA 1.05+0.65 ng/ml. During the first 4 weeks, there was a steady increase in pre-injection T from 19.14+3.48 to 23.89+9.15 nmol/l (p¼0.1). However, after 8 weeks the post-injection T (25.77+7.67 nmol/l) remained similar to that of week 1 (27.46+12.91 nmol/l). Patients tolerated this therapy with no adverse effects.

Conclusions: A once-week SC injection of 50–100 mg of TE appears to achieve sustainable and stable levels of physiological T. This technique offers fewer physician visits and the use of smaller quantity of medication, thus lower costs. However, the long term clinical and physiological effects of this therapy need further evaluation.


I did a run with subc back in April of 2009 and here was my log;

I have been on a cruise dose of 280mg per week of Testosterone Cypionate and decided I would try injecting my testosterone subcutaneously. I have never injected testosterone any other way than Intramuscularly until today. I decided to use up some pharm grade propionate that has been sitting around so I loaded up a 29 guage slin pin with 40mg of prop. This was 40 units as the prop is 100mg/ml. I warmed up the testosterone in a cup of hot water and swirled it around until it was very warm. It took about 2 minutes to load the pin as the oil is somewhat thick. I injected 2 inches to the right of my belly button into a fold of skin. The injection took about 20 seconds. I felt nothing except the needle penetrating the skin. Several hours later I now feel a slight burning sensation at the injection site. I will pin 40mg/40 units every day and record my experience here.

 

[heavyiron]

Re: Subcutaneous testosterone injections

If 40 units a day does not cause any problems with prop then using cyp at 200mg/ml that would equal 560mg per week. I still have some discomfort at the site and a small knot but time will tell how well this works.

My hope is to maintain very even blood androgen levels doing this. I hope those even androgen levels will reduce sides like acne. I also was thinking this would be an ideal way for ladies to use aas. Some adventursome women use Prop at 35-70 mg weekly.

 

[heavyiron]

Re: Subcutaneous testosterone injections

There are several things I hope to find out doing this. The first is how much volume can comfortably be injected right under the skin. In the trial they shot as much as .5 ml once weekly. I will shoot .4 ml every day for a while and experiment with various volumes after that.

I also wonder how much this will slow down the release of the ester. I know HCG is reportedly slowed down when shooting sub q verses IM.

 

[heavyiron]

Re: Subcutaneous testosterone injections

I have taken hundreds of subcutaneous injections but never with aas. It definately feels different from shooting a water based medicine like HCG. I chose a 1/2 inch pin as that should be deep enough with the volume I am using. I will shoot 2 inches to the left of my belly button tomorow and see how it goes from there.

 

[heavyiron]

Re: Subcutaneous testosterone injections

I will run this at various doses and using different esters until I feel I have answered my questions. I am interested to see how long the depot is felt under the skin and how painful this will compare to IM injections. I also would like to see if this frequent small dose administration reduces acne. There is also the issue of scar tissue with multiple IM injections so this may be a route for those who want to avoid scar tissue in the muscle. I also want to experience this so I can advise others on its use, particularly women. I imagine I can have a pretty decent working knowledge of this in a few weeks.


Day 2
Yesterdays injection site is still sore to the touch and I can feel a very small inflamed area. I injected 40mg of prop 2 inches to the left of my belly button subq this morning and felt no pain during the injection.

 

[heavyiron]

Re: Subcutaneous testosterone injections

Day 3
Both sites are still a little sore and inflamed. It feels different shooting sub q vs IM. I shot another 40iu and I barely felt the inject a few minutes ago.

 

[heavyiron]

Re: Subcutaneous testosterone injections

A subq inject is a little different. The pin should never penetrate the muscle at all. Additionally, the volumes I am using are quite small, 4/10ths of a cc. Here is an illustration of a subq inject. I am using a 29 guage 1/2" pin.

 

[heavyiron]

Re: Subcutaneous testosterone injections

I don't have any redness at any injection sites. I have slight localized swelling though.

Day 4
Pinned another 40iu test P subq in my stomach. I still have some minor swelling but very little pain.

 

[heavyiron]

Re: Subcutaneous testosterone injections

90 degree angle for injection, 45 degree angle if the pt has low body fat

 

[heavyiron]

Re: Subcutaneous testosterone injections

The Procedure.

1. Inform patient of the procedure and obtain consent


2. Check the five Rights and prepare and check the medication. In most institutions both nurses must check and sign for the medications.

3. Subcutaneous injections can be given at a 90 degree angle or at a 45 degree angle

4. Normal practice is to give the shot straight in at a 90 degree angle if 2 inches of skin can be grasped between the nurses thumb and first (index) finger

5. However, if only one inch of skin can be grasped the it is safer and less painful to give the injection at a 45 degree angle

6. Remove the alcohol with from the container

7. Cleanse the area where you plan to give the injection. Allow the area dry.

8. Remove the cover of the needle from the syringe

9. Hold the syringe in your writing hand and pull the cover off with the other hand

10. For a 45 degree angle injection hold the syringe with your dominant hand

11. Then place the syringe between your thumb and your index and second fingers. The needle should be pointing to the skin at the 45 degree angle.

12. For a 90 degree angle injection hold the syringe with your dominant hand

13. Then place the syringe under your thumb and first finger. Let the barrel of the syringe rest on your second finger. Some people hold a pen in this manner.

14. Hold the skin with the hand not holding the syringe. Holding the syringe barrel tightly using your dominant hand, use your wrist movement to inject the needle. Sometimes the needle goes in easily. At other times people have tougher skin and a little more pressure or force is used.

15. Push the plunger down to inject the medication into the patient

16. Gently withdraw the needle at the same angle you put it in...also release the pinched skin as you remove...better yet release it right before you remove the needle

17. Finally, wipe the area with the dry sterile gauze 2 x 2 pad

18. Dispose the syringe and needle in the sharps container, or in a used container of MUSCLETECH WEIGHT GAIN HARDCORE. =)

 

[heavyiron]

Re: Subcutaneous testosterone injections

Day 5
skipping administration today

 

[heavyiron]

Re: Subcutaneous testosterone injections

lol, I have 4 little sore spots that are slighty inflammed on my belly. I think I will switch to cyp tomorow, that way I will shoot only 20iu as it is twice the mg concentration as prop.

 

[heavyiron]

Re: Subcutaneous testosterone injections

Ok, I decided to switch over to cyp. I shot 20iu/40mg of TC in my left side above my hip about 2 minutes ago. It was painless to shoot but I will see if there is any pain later.

 

[heavyiron]

Re: Subcutaneous testosterone injections

I have had blood work that showed 250mg per week put me at the high end of the range for Total T but everyone is different so I imagine it varies from person to person.

 

[heavyiron]

Re: Subcutaneous testosterone injections

Ok, cyp was way better. Zero pain or discomfort!

Day 6
Shot 20iu/40mg of cyp sub q in my abdomen fat. zero pain during the inject other than slight pain when the needle broke the skin.