I know there are different lines of thinking on this, and I’m sure there is an advantage to a split protocol on higher dosages, and if you’re getting into insulin, and all that. I’m running the protocol that my doctor wants me to run, on pharma, although I’m running Optis because I can run a much higher dosage, much more affordably. I’m running 4iu, first thing in the am, and I don’t eat until 3 hours later, and I only run 5-6 days a week. Some of the stuff I’ve read says you want the single dosage, and a day or 2 a week off, to prevent shutdown of your natural production. Your body produces natural GH, while sleeping, which is part of the reason for the AM dose.