There are oddities and enigmas surrounding cardarine, so much so, some conspiracy theorists have come to the conclusion that its reputation was purposefully tarnished in order to keep people unhealthy and dependent on the medical industry. I'm certainly not trying to say that's the case with this thread, but it's worth discussing so we can separate the fact from myth.
The way drugs generally make it through clinical trials, they start with animal administration. If that goes well, they move to human administration for the next few phases of the trial. Interestingly, cardarine's infamous "cancerous rat" trial seemingly didn't even exist, until cardarine was being widely deployed by virtually every single athlete in the Beijing Olympics. At that point, it hadn't shown any ill effects on human subjects -- quite the contrary, as it was being advertised and billed as "exercise in a bottle" by the manufacturer. It had even shown up in news specials, and hailed as a miracle drug by GlaxoSmithKline.
After the compound started to see explosive use in athletes, this mystery study sprouted out of nowhere, showing cancer in rat subjects after a supposed 2 year administration. For some strange reason, it shouldn't have ever progressed to human trials, but certainly had, with no one experiencing a single effect that forced them out of the trial. So, either GlaxoSmithKline had buried that phase of the trial, or something else entirely had happened. Fishing through the available information on the subject, GlaxoSmithKline was never charged with any wrong doing, so it's unlikely they hid the results from a trial, especially since it would have been handed over to the FDA before human trials could even begin.
To compound the mysterious nature of the situation even further, the particular rats used in this study only live (on average) to the age of 3 years old any way, at which point they die of cancer. So why were they used for this study? Further, human trials have shown cardarine possessing anti cancer properties, especially regarding pituitary tumors. In fact, one study on rats showed promising anti pituitary tumor effects, to such an extent that many of the rats were completely cured by the end of the study, and a dramatic reduction in the size of the tumor across the entire study group.
With a bit of context, it's easy to see how some people aren't convinced of cardarine's supposed cancer proliferation in rat models.
To be very clear, there isn't a single recorded instance of a person developing cancer while using cardarine, and it has been widely used for well over a decade.
Cardarine is a ppar delta agonist, yielding desirable effects on blood lipids, blood pressure, and a palpable, performance-enhancing effect on cardiovascular capacity. Further, it might even have mildly anabolic effects, although that hasn't been shown in humans. It has also been shown to heal dead heart cells, and reverse ventricular hypertrophy. Cardarine also aids in metabolizing bodyfat.
Getting into anecdotes, I have used cardarine multiple times and absolutely love it. Even when performing anaerobic exercises, I noticed an immediate difference. I can hold a paused squat while holding my breath, with far less stress on my cardiovascular system. I can push harder during any lift, without losing my breath. But when performing aerobic movements, it's quite simply amazing.
A quick look around online yields stories of guys self administering cardarine in order to treat severe cardiovascular impairment, with results that seem too good to be true, but are beyond profound if they are true. Like this one:
View: https://www.youtube.com/watch?v=pw300NEsZq8
A list of all published studies around cardarine: SAGE Journals: Your gateway to world-class research journals
I wanted to start this thread to demystify cardarine a bit, since so many people claim it's the devil, while many others claim it's a miracle drug. What's the truth? Well, without major funding, we'll probably never know. But if we really look at the facts, there is no evidence that it causes cancer in humans, and it has profound cardiovascular effects. It has shown anti cancer properties in humans and animals. And there is trial showing supposed cancer proliferation in rats, but this trial is not peer reviewed, and there are multiple potential problems with that particular trial.
What do you guys think? What are your experiences with cardarine?
The way drugs generally make it through clinical trials, they start with animal administration. If that goes well, they move to human administration for the next few phases of the trial. Interestingly, cardarine's infamous "cancerous rat" trial seemingly didn't even exist, until cardarine was being widely deployed by virtually every single athlete in the Beijing Olympics. At that point, it hadn't shown any ill effects on human subjects -- quite the contrary, as it was being advertised and billed as "exercise in a bottle" by the manufacturer. It had even shown up in news specials, and hailed as a miracle drug by GlaxoSmithKline.
After the compound started to see explosive use in athletes, this mystery study sprouted out of nowhere, showing cancer in rat subjects after a supposed 2 year administration. For some strange reason, it shouldn't have ever progressed to human trials, but certainly had, with no one experiencing a single effect that forced them out of the trial. So, either GlaxoSmithKline had buried that phase of the trial, or something else entirely had happened. Fishing through the available information on the subject, GlaxoSmithKline was never charged with any wrong doing, so it's unlikely they hid the results from a trial, especially since it would have been handed over to the FDA before human trials could even begin.
To compound the mysterious nature of the situation even further, the particular rats used in this study only live (on average) to the age of 3 years old any way, at which point they die of cancer. So why were they used for this study? Further, human trials have shown cardarine possessing anti cancer properties, especially regarding pituitary tumors. In fact, one study on rats showed promising anti pituitary tumor effects, to such an extent that many of the rats were completely cured by the end of the study, and a dramatic reduction in the size of the tumor across the entire study group.
With a bit of context, it's easy to see how some people aren't convinced of cardarine's supposed cancer proliferation in rat models.
To be very clear, there isn't a single recorded instance of a person developing cancer while using cardarine, and it has been widely used for well over a decade.
Cardarine is a ppar delta agonist, yielding desirable effects on blood lipids, blood pressure, and a palpable, performance-enhancing effect on cardiovascular capacity. Further, it might even have mildly anabolic effects, although that hasn't been shown in humans. It has also been shown to heal dead heart cells, and reverse ventricular hypertrophy. Cardarine also aids in metabolizing bodyfat.
Getting into anecdotes, I have used cardarine multiple times and absolutely love it. Even when performing anaerobic exercises, I noticed an immediate difference. I can hold a paused squat while holding my breath, with far less stress on my cardiovascular system. I can push harder during any lift, without losing my breath. But when performing aerobic movements, it's quite simply amazing.
A quick look around online yields stories of guys self administering cardarine in order to treat severe cardiovascular impairment, with results that seem too good to be true, but are beyond profound if they are true. Like this one:
View: https://www.youtube.com/watch?v=pw300NEsZq8
A list of all published studies around cardarine: SAGE Journals: Your gateway to world-class research journals
I wanted to start this thread to demystify cardarine a bit, since so many people claim it's the devil, while many others claim it's a miracle drug. What's the truth? Well, without major funding, we'll probably never know. But if we really look at the facts, there is no evidence that it causes cancer in humans, and it has profound cardiovascular effects. It has shown anti cancer properties in humans and animals. And there is trial showing supposed cancer proliferation in rats, but this trial is not peer reviewed, and there are multiple potential problems with that particular trial.
What do you guys think? What are your experiences with cardarine?
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