AAS and Cardiovascular/Pulmonary Function

[Millard]

Why did Michael Scally MD and Dr JIM stop participating here?

As far as the former, I am guessing it was likely due to the number of forum members who stalked and harassed him from thread to thread, publicly and privately, over political issues. Dr. Scally never engaged or responded to them, yet they persisted. I miss him, and plan on inviting him back, hoping to see him return. Obviously, I will be disappointed if he doesn't but I would completely understand and honestly would not blame him. In hindsight, I should have done more to stop the harassment and feel a great deal of responsibility for not doing so.

 

[KernelPanicFrenzy]

You are interfering with his personal ambitions.

If you introduce AAS, peptides, etc. it will likely compromise the prospects of a published case study.

Don't let that deter you from being honest with him - for the sake of scientific accuracy and disclosure. You are doing a disservice to the scientific community if you fail to disclose knowing that he will publish false information.

If he writes the study without asking me more info, thats on him. I need them to get health care. If I get myself removed as a patient for using unregulated chinese peptides, I will be doing myself a disservice. So, Ill tread carefully.

 

[eryximachus]

Not because its actually bad for my condition, but because he has a dislike for TRT and GH in general.

Any ideas why?

I feel like 20 years ago, before the obesity crisis became such an epidemic, this was an easier view to hold. Then there's the whole wide world of transgender people. We should be entering a new world of hormones. Ah well, I'm pontificating.

 

[KernelPanicFrenzy]

Any ideas why?

I feel like 20 years ago, before the obesity crisis became such an epidemic, this was an easier view to hold. Then there's the whole wide world of transgender people. We should be entering a new world of hormones. Ah well, I'm pontificating.

His wife is an Endo, so she probably tells him about guys coming in with 500 testosterone wanting to be put on TRT? IDK

I think using testosterone to maximize performance has been demonized, and it still is, but I think it shouldn't be.

Has nothing to do with transgenders. That is not TRT.

 

[Eddie.]

Some interesting talk from Andrew Winge MD


View: https://youtu.be/W230F9vtYHc?si=iUSx0oJhpCZiiBSE

 

[lestatgear]

I’ve been involved in this game and using PED’s for the better part of 25 years. I get regular blood work and have been open with my use to my doctors. Here’s been my experience.

I have a bad history of heart disease and issues on my father’s side. My father was a competitive bodybuilder and used AAS back in the 80’s. He died at age 37 due to cardiomyopathy. Now his father, who never touched a steroid, or worked out for that matter, died of a heart attack at 42.

My first heart issue came in the form of pericarditis, an inflammation of the outer protective sheath of the heart. Felt like I was having a heart attack. I do believe this was steroid induced. This resulted in regular blood work and heart exams due to my family history.

Over the years I’ve had progressing left ventricle hyperteophy. It started as mild and progressed to moderate borderline severe. This has been measured by multiple echocardiograms over the years. It has taken 20 years to progress from mild to high moderate. However, my heart function is not affected.

I also have a faulty aeortic valve, but this is hereditary per my cardiologist. So, I have a combination of “heart issues” some possibly attributed to AAS use over the years and some genetic.

Based on my family history I had no expectation of living past 40 but despite these issues, I’m 53 and going strong and have been running gear for 25 years. However, my doses and the compounds I can tolerate have decreased year over year for the past 10 years or so.

 

[KernelPanicFrenzy]

I’ve been involved in this game and using PED’s for the better part of 25 years. I get regular blood work and have been open with my use to my doctors. Here’s been my experience.

I have a bad history of heart disease and issues on my father’s side. My father was a competitive bodybuilder and used AAS back in the 80’s. He died at age 37 due to cardiomyopathy. Now his father, who never touched a steroid, or worked out for that matter, died of a heart attack at 42.

My first heart issue came in the form of pericarditis, an inflammation of the outer protective sheath of the heart. Felt like I was having a heart attack. I do believe this was steroid induced. This resulted in regular blood work and heart exams due to my family history.

Over the years I’ve had progressing left ventricle hyperteophy. It started as mild and progressed to moderate borderline severe. This has been measured by multiple echocardiograms over the years. It has taken 20 years to progress from mild to high moderate. However, my heart function is not affected.

I also have a faulty aeortic valve, but this is hereditary per my cardiologist. So, I have a combination of “heart issues” some possibly attributed to AAS use over the years and some genetic.

Based on my family history I had no expectation of living past 40 but despite these issues, I’m 53 and going strong and have been running gear for 25 years. However, my doses and the compounds I can tolerate have decreased year over year for the past 10 years or so.

Take a look at tirzepatide. It's been shown now to shrink heart cells. It reversed my aortic stenosis.

I'd also look into Ss-31 "Elamipretide"

 

[Ghoul]

Take a look at tirzepatide. It's been shown now to shrink heart cells. It reversed my aortic stenosis.

I'd also look into Ss-31 "Elamipretide"

I was just about to mention this.

Tirz has been shown to reverse left ventricular hypertrophy via mechanisms apart from weight loss alone.

"Kramer, a cardiovascular imager, also led a magnetic resonance imaging substudy looking at how tirzepatide, sold under the brand name Zepbound, affected recipients’ heart structure and function. The researchers found beneficial reductions in both left ventricular mass (weight of the heart) and in the amount of surrounding fat tissue. The reduction in LV mass correlated with the reduction in body weight, as well as with decreases in left ventricular volumes.

“This drug is reversing the abnormal properties of the heart brought on by obesity,” Kramer said. “There is much more to these drugs than weight loss alone.”

In other words, LV Hypertrophy brought on by stress, in this case obesity, is being reversed. I'm sure I've seen another study that showed the improvement was even greater in normal weight subjects, a rarity, as so little of the massive amount of research going on into GLPs involves normal weight or non-diabetic subjects.

Weight-Loss Drug Tirzepatide Reduces Heart Failure Deaths

Tirzepatide, from pharmaceutical company Eli Lilly and Co., was tested in the SUMMIT clinical trial at 146 sites in the United States and abroad.

newsroom.uvahealth.com

There's a link between endotoxin exposure and heart remodeling, and Tirz appears to affect that pathway to stop progressive worsening of the condition, and even reverses it.