Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats. - PubMed - NCBI
Supraphysiological doses of nandrolone exacerbated the cardiac hypertrophy in exercise-trained rats. Exercise training associated with nandrolone induces maladaptive remodeling and further deterioration in cardiac performance. Exercise training associated with nandrolone causes loss of the beneficial effects in left ventricular function induced by exercising. These results suggest that aerobic exercise plus nandrolone increases cardiac collagen content associated with activation of the local renin-angiotensin system.
Chronic treatment with anabolic steroids induces ventricular repolarization disturbances: cellular, ionic and molecular mechanism. - PubMed - NCBI
The illicit use of supraphysiological doses of nandrolone has been suggested as a cause of arrhythmia in athletes... Our results strongly suggest that supraphysiological doses of nandrolone induce morphological remodeling in both ventricles. However, the electrical remodeling was mainly observed in the left ventricle.
Nephrotoxicity in rabbits after long-term nandrolone decanoate administration. - PubMed - NCBI
Among the various side effects of supra-physiological dose of anabolic androgenic steroids that are described, renal toxicity remains the least evaluated. The present study provides evidence that long-term administration of nandrolone decanoate could lead to alterations of renal function and structure... In conclusion, nephrotoxicity of nandrolone decanoate remains a multi-factorial, partly irreversible effect that involves augmented tissue oxidative status.
The risk of life-threatening ventricular arrhythmias in presence of high-intensity endurance exercise along with chronic administration of nandrolo... - PubMed - NCBI
Nandrolone plus severe exercise increases the risk of VF that cannot be explained only by the changes in redox system. The intensification of cardiac hypertrophy and prolongation of JT interval may be a part of involved mechanisms.
Cardiopulmonary reflex, cardiac cytokines, and nandrolone decanoate: response to resistance training in rats. - PubMed - NCBI
The association of nandrolone with resistance training increased myocyte hypertrophy, deposition of matrix type I collagen, TNF-α and ACEA; decreased IL-10, and impairment in the BJR were observed in ND+EXERC compared with CONT and EXERC. Nandrolone is associated with alterations in cardiac structure and function as a result of the development of pathological cardiac hypertrophy (cardiac cytokine imbalance, elevation of ACEA) and cardiac injury, even when combined with resistance training.
The impact of nandrolone decanoate on the central nervous system. - PubMed - NCBI
According to Magnusson K. et al, nandrolone administered male rats displayed memory function impairment, possibly via dynorphinergic mechanisms in the hippocampus. The hippocampus is a brain region associated with cognitive function since the limbic brain is linked to several types of learning and memory functions. This region displays a relatively high density of androgen receptors in rats, which suggests a relationship between the androgen receptor and cognitive function.
In animal models, nandrolone has been implicated in memory loss
The effect of nandrolone on HPAA has been shown in some studies. Effects on the corticosterone, adrenocorticotropin hormone, proopiomelanocortin, corticotropin releasing factor (CRF) and CRF receptor1 (CRF R1) mRNA in the pituitary, hypothalamus and amygdala of rats have been noted. Moreover effects of nandrolone on adiponectin, insulin, ghrelin, leptin and corticosterone (CORT), and cortical serotoninergic system (CSS) have been observed.
Nandrolone has been shown to not only inhibit the Hypothalamic-Pituitary-Gonadal axis (HPGA) but also the Hypothalamic-Pituitary-Adrenal axis (HPAA), resulting in the decrease of hormones such as aldosterone and cortisol.
