Because we have loads of data, ranging from clinical all the way down to user anecdotes, and they all say the exact same thing about anavar and the safety of the drug at various doses. 5mg will be approximately the same as 0mg, except one of those costs you money and the other is free. If you want to be safe then by all means start at 25mg. That’s about the floor for an effect dose for a male. There’s very little reason to go above 50mg, so now you’ve got a set range based on evidence and not some strange fear of the safest methylated oral available to us. For some perspective I was prescribed anavar at 50mg/d for 100 days. Note that I said prescribed. As in a licensed physician in the United States gave me that and was unconcerned about the safety of either the dose or the duration. And ftr my blood work looked pretty much the same as it did before using anavar. Lipids got hit a little, but otherwise everything was fine.