Daily Log to 2019 Show Season

Great, reasonable. I seriously support your principles of progressive overload & only dosing to continue progress at a solid rate, upping dose and adding new potent compounds as plateau busters, application of sound training principles. This is stark contrast to the guys that promote maximal tolerable dosing year-round (fear-driven; cannot stand to think about or see 0.5 mg of muscle loss).

Have you used YK11 before? I'd be interested in your impressions and musings, anything and everything that you can share about it.
I have used it before, up to 20 mg ramped from 10 in 5mg increments. No comment on the myostatin inhibition claims however it did what I wanted it to do mid cycle; easy oral push thru that initial middle blast plateau. I also found it completely absent of any “toxicity” side effects other orals tend to give and did not impact my appetite whatsoever. Was fairly cheap, worked, bloodwork post cycle was great. Can’t complain.
 
I have used it before, up to 20 mg ramped from 10 in 5mg increments. No comment on the myostatin inhibition claims however it did what I wanted it to do mid cycle; easy oral push thru that initial middle blast plateau. I also found it completely absent of any “toxicity” side effects other orals tend to give and did not impact my appetite whatsoever. Was fairly cheap, worked, bloodwork post cycle was great. Can’t complain.
Interesting that you say you're not sure whether true that it acts to inhibit myostatin. I though for sure it was selective to MSTN, but not so - apparently it acts at the AR (and a Nad+ Hydrolase Sarm1 protein/enzyme) as well.

Did you notice strength increases, or just increased muscle size?
 
Interesting that you say you're not sure whether true that it acts to inhibit myostatin. I though for sure it was selective to MSTN, but not so - apparently it acts at the AR (and a Nad+ Hydrolase Sarm1 protein/enzyme) as well.

Did you notice strength increases, or just increased muscle size?
Definitely a little bump to strength but nothing crazy. Only oral to ever jack up strength for me is halo. I’m sure at higher initial doses you’d feel a jolt, but I prefer the slow ramp and as little as needed so.

I would love if it did actually impact myostatin or drive follistatin in whatever moa is theorized but I honestly just don’t stay in the know enough to see where that knowledge has gone. I deploy it mid-cycle as if it does hit myostatin, as last I checked myostatin peaks “mid cycle” on a reasonable length blast, but could be out of date there too.
 
Definitely a little bump to strength but nothing crazy. Only oral to ever jack up strength for me is halo. I’m sure at higher initial doses you’d feel a jolt, but I prefer the slow ramp and as little as needed so.

I would love if it did actually impact myostatin or drive follistatin in whatever moa is theorized but I honestly just don’t stay in the know enough to see where that knowledge has gone. I deploy it mid-cycle as if it does hit myostatin, as last I checked myostatin peaks “mid cycle” on a reasonable length blast, but could be out of date there too.
I'd say that it does: in C2C12 myoblasts (basically murine pre-muscle cells), "YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody. These results suggest that the induction of Fst is important for the anabolic effect of YK11."

It's an interesting little compound, sort of pluripotent, by acting as a SARM (partial AR agonist) and myostatin inhibitor.
 
Great, reasonable. I seriously support your principles of progressive overload (with volume & tension methods, intensifiers added as necessary) & only dosing to continue progress at a solid rate, upping dose and adding new potent compounds as plateau busters, application of sound training principles. This is stark contrast to the guys that promote maximal tolerable dosing year-round (fear-driven; cannot stand to think about or see 0.5 mg of muscle loss).

Have you used YK11 before? I'd be interested in your impressions and musings, anything and everything that you can share about it.
I also like his approach very much, thoughtful and reasonable. Very always useful to read his posts learn a lot.
 
Tentative plan for this blast:

Weeks 1-6
500 test
300 primo

Weeks 7-12
500 test
300 primo
200 deca
10mg YK11

Weeks 13-18
750 test
300 primo
200 deca
15-20mg YK11

Weeks 19-24
750 test
600 primo
200 deca
Most likely an oral to finish

6iu GH thruout, slin undecided but most likely also following J3U principles (most of my concepts arrived at on my own mirror Jewett’s now publicized advice so I’m jumping in that boat for GH and slin for a bit as well)

Sdrol, anadrol, tren on hand for any significant plateaus training and food or the natural progression can’t handle.

The idea here is slow anabolic progression (just like food and training) but this is just an outline. Won’t budge drugs if progress continues. This should allow me to use fewer mg and force growth slower over a longer period with the goal of more healthy adaptation to new weight/strength.
We might fairly call this YK-11 usage the Mac11wildcat YK-11 protocol. It's consistent with the findings of:

Lakshman, K. M., Bhasin, S., Corcoran, C., Collins-Racie, L. A., Tchistiakova, L., Forlow, S. B., … LaVallie, E. R. (2009). Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration. Molecular and Cellular Endocrinology, 302(1), 26–32. doi:10.1016/j.mce.2008.12.019

That found that, given graded doses of testosterone enanthate up to 300 mg (600 mg group was terminated and excluded due to adverse events in the older men group) resulted in MSTN concentrations peaking at day 56 and returning to base-line at day 140:
Myostatin-change-T-administration-young-older-men-Graphs.MesoRX.png
 
We might fairly call this YK-11 usage the Mac11wildcat YK-11 protocol. It's consistent with the findings of:

Lakshman, K. M., Bhasin, S., Corcoran, C., Collins-Racie, L. A., Tchistiakova, L., Forlow, S. B., … LaVallie, E. R. (2009). Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration. Molecular and Cellular Endocrinology, 302(1), 26–32. doi:10.1016/j.mce.2008.12.019

That found that, given graded doses of testosterone enanthate up to 300 mg (600 mg group was terminated and excluded due to adverse events in the older men group) resulted in MSTN concentrations peaking at day 56 and returning to base-line at day 140:
View attachment 172816
Hey that’s pretty good. Lol.

Day 40-140 is just about week 7-19. :)
 
-cystatin-c still pending for some reason

It took me almost three weeks to get this result back. I live in Toronto and when I finally got the result back, it showed that the sample had been sent to San Diego, California for testing, which explains the long waiting time.

Do you take/do anything to mitigate the effects of AAS on LVH or atherosclerosis? These are my two biggest concerns.

From what I understand, AAS binds directly to the androgen receptors of the heart, which can cause LVH. So even if your blood pressure is fine, you are still susceptible to LVH. I think I also read before that AAS can accelerate atherosclerosis, even if cholesterol is good.
 
It took me almost three weeks to get this result back. I live in Toronto and when I finally got the result back, it showed that the sample had been sent to San Diego, California for testing, which explains the long waiting time.

Do you take/do anything to mitigate the effects of AAS on LVH or atherosclerosis? These are my two biggest concerns.

From what I understand, AAS binds directly to the androgen receptors of the heart, which can cause LVH. So even if your blood pressure is fine, you are still susceptible to LVH. I think I also read before that AAS can accelerate atherosclerosis, even if cholesterol is good.
Metformin and telmisartan. Nebivolol can also help I think. Stay active, keep lipids in devent shape, and be ready to live with some LVH. Plenty of reasonable supplemental approaches to lipid management (citrus bergamot being huge) but proper food choice can go a long way.
 
Metformin and telmisartan. Nebivolol can also help I think. Stay active, keep lipids in devent shape, and be ready to live with some LVH. Plenty of reasonable supplemental approaches to lipid management (citrus bergamot being huge) but proper food choice can go a long way.

Do you take the Metformin to keep your lipids in range, or does it have benefits as well (if your lipids are already in range)?
 
Do you take the Metformin to keep your lipids in range, or does it have benefits as well (if your lipids are already in range)?
Metformin primarily for insulin sensitivity but it has a shit ton of benefits including helping LVH. Unsure of impact on lipids.

Edit;FB8C200D-BA60-466B-9857-AEB9C2CD0640.png
 
Just read the entire log! This is a nice story (i.e., road to pro etc) and with some solid advice. The whole peaking aspect was confusing to be honest, but nothing I have to worry about for a while. Really appreciate the detailed info on training, diet and those mid cycle plateau buster approaches (e.g., add an oral when progress stalls and food and training aren't helping). Actually added in an arms day to my PPL routine. Hoping it will help recovery a bit as I won't be hitting so many big body parts as often. Thanks for the log and keep doing what you're doing!
 
How do you feel, the consequences of covid no longer affect training and health?
I have never once given a single thought to Covid after the first ~4 weeks when things were truly uncertain. After those 4 weeks shit was crystal clear. My stance on vaccination, especially for athletes, hasn’t changed and I’m glad I have as strong a sense of direction and steadfastness as I do to have told people pressuring me to get it to pound sand.
 
I have never once given a single thought to Covid after the first ~4 weeks when things were truly uncertain. After those 4 weeks shit was crystal clear. My stance on vaccination, especially for athletes, hasn’t changed and I’m glad I have as strong a sense of direction and steadfastness as I do to have told people pressuring me to get it to pound sand.
my man.
 
I have never once given a single thought to Covid after the first ~4 weeks when things were truly uncertain. After those 4 weeks shit was crystal clear. My stance on vaccination, especially for athletes, hasn’t changed and I’m glad I have as strong a sense of direction and steadfastness as I do to have told people pressuring me to get it to pound sand.
While I’m 100% with you, I’m thinking @JesterBOB may have confused you and @Palifter though I could certainly be wrong
 
While I’m 100% with you, I’m thinking @JesterBOB may have confused you and @Palifter though I could certainly be wrong
My thought, exactly. palifter had covid in prep and is just now recovered.
 
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