Clappincheeks
Member
so what best course of action to reverse this type of insulin resistance. this becomes so much of a problem for me i have to discount it.Exactly, your body is pumping out A LOT more insulin to keep your blood glucose at 74.
It's a different type of insulin resistance than you are used to seeing.
Again, your blood glucose and A1C can be in completely normal and healthy range, but your pancreas is pumping out a ton of insulin to keep it that way. Does that make sense to you now?
You can look at a ton of different studies that don't just look at glucose and A1C but actual serum insulin concentrations and HOMA index.
Most laymen are only aware of fasting glucose and hBA1C (glycate hemoglobin) but there is a lot more to insulin function and sensitivity than that.
You can be quite insulin resistant and have excellent fasting glucose and hBA1C numbers.
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Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults - PubMed
Twice-daily GH injections, apart from producing a more physiological serum GH profile, were superior to one injection in increasing serum IGF-I and decreasing IGFBP-1 levels. Both of these changes tend to amplify the effects of the administered GH. Twice-daily injections, however, resulted in...pubmed.ncbi.nlm.nih.gov
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More Favorable Metabolic Impact of Three-Times-Weekly versus Daily Growth Hormone Treatment in Naïve GH-Deficient Children - PubMed
The TIW regimen is effective and comparable with the daily regimen in improving auxological parameters and has a more favorable metabolic impact in GHD children. This trial is registered with ClinicalTrials.gov NCT03033121.pubmed.ncbi.nlm.nih.gov